tablets Linessa are shown for treatment of the infections caused by sensitive strains of anaerobic or aerobic gram-positive microorganisms including the infections which are followed by bacteremia, such as:

• nozokomialny pneumonia;
• community-acquired pneumonia;
• complicated infections of skin and its structures, in particular infections against the background of diabetic foot without the accompanying osteomyelitis, the caused Staphylococcus aureus (metitsilinchutlivima and Methicillinum - resistant isolates), Streptococcus pyogenes or Streptococcus agalactiae;
• uncomplicated infections of skin and its structures caused by Staphylococcus aureus (only Methicillinum - sensitive isolates) or Streptococcus pyogenes;
• an infection, caused by enterococci, including strains of Enterococcus faecium and faecalis, resistant to Vancomycinum.

Structure

Active ingredient: linezolid.

1 tablet, coated, supports a linezolid of 600 mg.

Excipients: cellulose microcrystalline lactose monohydrate, povidone, talc of sodium of a kroskarmelloz; magnesium silicon stearate dioxide colloidal starch sodium (type A); gipromelloza of E-15; titan E 171 dioxide; polyethyleneglycol-6000; propylene glycol.

Contraindication

Hypersensitivity to a linezolid or any other component of drug.

or took any medications suppressing monoamine oxidase A and B (for example, fenelzin, an isocarboxazid, selegilin, moklobemid) or within 2 weeks after intake of such drugs.

except for cases when there is a possibility of careful observation and monitoring of arterial blood pressure, with the accompanying clinical states or the accompanying administration of drugs:

• uncontrollable arterial hypertension, thyrotoxicosis, pheochromocytoma, carcinoid, bipolar depression, schizoaffective disorder, sharp episodes dizziness;
• inhibitors of the return serotonin reuptake, tricyclic antidepressants, agonists 5-HT 1 of receptors of serotonin (triptanes), direct and indirect sympathomimetics (including adrenergic bronchodilators, pseudoephedrine, fenilpropanolamin), vazopressor (epinephrine, Norepinephrinum), dofaminergichesky connections (dopamine, Dobutaminum), pethidine or buspiron.

by

to treatment linezolidy for oral administration. In that case selection of a dose is not necessary as the bioavailability of a linezolid at intake is nearly 100%.

Feature of use

Pregnant

during pregnancy, except cases when the expected advantage for mother exceeds potential risk for a fruit.

Children

do not appoint Drug to children aged up to 12 years.

Drivers

With care.

for

.

by

did Not register overdose cases.

to

in case of overdose showed symptomatic treatment with holding actions for support of level of glomerular filtration. About 30% of the accepted dose of medicament are removed during 3:00 a hemodialysis, but there are no data on a conclusion of a linezolid during the procedures of peritoneal dialysis or hemoperfusion. Two primary metabolites of a linezolid are also removed by a hemodialysis.

Side effects

Most frequent side reactions which led to medicament withdrawal were a headache, diarrhea, nausea and vomiting.

Linezolid is not applied by

to the patients accepting the medicines suppressing MAO A and In (for example, fenelzin, an isocarboxazid, selegilin, moklobemid), and within 2 weeks after their reception.

Storage conditions

to Store

at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date: 3 years.