Levokilz – antibacterial agent of group of hinolon.

adult for treatment of such infections:

• Acute bacterial sinusitis.
• Exacerbation of a chronic obstructive disease of lungs, including bronchitis.
• Not hospital pneumonia.
by
• complicated infections of leather and soft tissues.
• Uncomplicated cystitis.

In above-mentioned infections medicament should be used only when it is considered inexpedient to use the antibacterial medicines which are usually recommended for initial treatment of these infections.

• Acute pyelonephritis and the complicated urinary tract infections.
• Chronic bacterial prostatitis.
• Inhalation anthrax: post-contact prevention and treatment.

for end of a course of therapy at patients at whom improvement is noted during initial treatment levofloksatsiny intravenously.

Structure

• active ingredient: levofloxacin;
• 1 tablet, film coated, contains levofloxacin gemigidrat (it is equivalent levofloxacin) 250 mg or 500 mg;
• other components: sodium of a kroskarmeloz, cellulose microcrystalline, gipromeloz (hydroksipropilmetiltsellyuloz), magnesium stearate, titan dioxide (E 171), macrogoal 400, talc, ferrous oxide yellow (E 172), gland oksid2 red.

Contraindication

• Hypersensitivity to a levofloksatsin, other ftorkhinolona or any component of medicine.
• Epilepsy.
Injury of a sinew is connected by
• with preliminary application of ftorkhinolon.
• Children's age.
• Period of pregnancy and feeding by a breast.

Side reactions

Infection and an invasion – a fungal infection, including the infection caused by sort Candida fungi, resistance of pathogenic microorganisms.

from the system of blood and lymphatic system – a leukopenia, an eosinophilia, thrombocytopenia, a neutropenia, a pancytopenia, the Agranulocytosis, hemolytic anemia.

from the immune system – a Quincke's disease, hypersensitivity, an acute anaphylaxis, anaphylactoid shock.

from metabolism and food - anorexia, a hypoglycemia, especially at patients with diabetes, a hyperglycemia, a hypoglycemic coma

Mental disorders - insomnia, uneasiness, confusion of consciousness, nervousness, psychotic reactions (for example, hallucinations, paranoia), a depression, agitation, unusual dreams, night horrors. Psychotic reactions with self-destructive behavior, including suicide orientation of thinking.

from nervous system - a headache, dizziness, drowsiness, a tremor, a dysgeusia, spasms, paresthesia, peripheral touch neuropathy, peripheral sensomotor neuropathy, a parosmiya, including an anosmia, dyskinesia, extrapyramidal frustration, an ageusia, syncopes.

Gepatobiliarny frustration - increase in indicators of hepatic enzymes (ALT/nuclear heating plant, alkaline phosphatase, GGT), increase in bilirubin of blood, jaundice and severe damage of a liver, including cases of a lethal acute liver failure, mainly at patients with serious basic diseases.

Route of administration

should take the Pill Levokilza 1 or 2 times a day. The dose depends on type, weight of an infection and sensitivity of the expected activator.

for end of a course of therapy at patients at whom improvement is shown during initial treatment levofloksatsiny intravenously; considering bioequivalence of parenteral and oral forms, it is possible to apply an identical dosage.

Use during pregnancy or feeding by a breast

Data on application of a levofloksatsin to pregnant women are limited to

Feature of application

data on researches on animals who do not point to a direct or indirect adverse effect on reproductive toxicity Exist. However due to the lack of researches of impact on a human body and on the basis of the experimental data indicating risk of damage of a ftorkhinolonama of an articulate cartilage of the growing organism, it is impossible to appoint levofloxacin pregnant.

Levofloxacin is contraindicated to the nursing women.

Children

Drug is contraindicated to children up to 18 years.

Some side reactions (for example, dizziness / vertigo, drowsiness, a disorder of vision) the ability of the patient to concentration of attention and speed of its reaction can break

and, thus, to cause the increased risk in situations when these qualities are of particular importance (for example, during the driving or work with mechanisms).

Overdose

According to toxicity researches on animals or to the clinical pharmacological trials conducted at application of doses above therapeutic, the major signs which should be expected after sharp overdose of a levofloksatsin are symptoms from the central nervous system, such as confusion of consciousness, dizziness, violation of consciousness and spasms. attacks, lengthening of an interval of QT and also gastrointestinal reactions, such as nausea and erosion mucous.

At post-marketing application of a levofloksatsin observed effects from central nervous system, including confusion of consciousness, a spasm, hallucination and a tremor.

in case of overdose symptomatic treatment. It is necessary to carry out monitoring of the ECG as there is a possibility of lengthening of a QT interval. For protection mucous a stomach it is possible to use antacids. The hemodialysis, including peritoneal dialysis and HAPD, are not effective for removal of a levofloksatsin from an organism. There are no specific antidotes.

to Store

out of children's reach at a temperature above 30 °C.