Labletki Lerkamen 10 are shown in essential hypertensia of light or moderate severity.

Structure

Active ingredient: 1 tablet, coated, supports a lerkanidipin of a hydrochloride of 20 mg that there corresponds the lerkanidipina of 18.8 mg;

Excipients: lactose, cellulose microcrystalline, starch sodium (type A), K 30 povidone, magnesium stearate;

Cover: Opadry 02F25077 (gipromelloza, talc, titan dioxide (E 171), macrogoal 6000, ferrous oxide (E172)).

Contraindication

• Hypersensitivity to active ingredient or to any excipient of medicine.
• Obstruction of the vessels leaving a left ventricle.
• Not treated stagnant heart failure.
• Unstable stenocardia or recently (within 1 month) the postponed myocardial infarction.
• Heavy abnormal liver function.
• Heavy renal failure (SKF <30 ml/min.), including at the patients who are on dialysis.
• Simultaneous use with: strong CYP3A4 inhibitors, cyclosporine, grapefruit or juice of grapefruit.

Route of administration

Security measure which should be observed at intake of medicine or at treatment of him:

• Medicine should be accepted mainly in the morning, at least in 15 minutes prior to a breakfast.
• It is medicine it is not necessary to accept with grapefruit juice.

Recommended dose makes 10 mg orally 1 time a day at least in 15 minutes prior to food the dose can be raised to 20 mg depending on individual sensitivity of the patient. Selection of a dose has to be gradual as maximum antihypertensive action can be shown in 2 weeks after an initiation of treatment.

Pregnant

it is not recommended by

Feature of use

it is not recommended by

to p to use.

Drivers

With care.

Overdose

As well as in case of other dihydropyridines, the overdose lerkanidipiny leads to an excessive peripheral vazodilatation with the profound arterial hypotension and reflex tachycardia. However at use of medicament in very high doses the loss of peripheral selectivity is possible that it causes bradycardia and negative inotropic effect. Arterial hypotension, dizziness, a headache and heartbeat were the most frequent side reactions caused by overdose.

Treatment. Patients from clinically significant arterial hypotension demands active cardiovascular support, including frequent control of warm and respiratory function, horizontal position with the raised lower extremities, control of volume of the circulating liquid and a diuresis

Side effects

Side reactions, the message about most of which often was received during clinical trials and postregistration supervision: peripheral hypostases, a headache, rush of blood suit, tachycardia and the strengthened heartbeat.

Interaction

Contraindicated simultaneous use with: strong CYP3A4 inhibitors, cyclosporine, grapefruit or juice of grapefruit.

Should avoid alcohol intake as it can strengthen effect of vasodilating antihypertensive medicines.

Special storage conditions are not required for

.

Medicine to store

in original packing.

to Store

out of children's reach!

Expiration date - 3 years.