Legato kaps. it is firm. 75 mg No. 21

Ligato capsules are appointed for treatment:

• Neuropatichesky pain. Drug is shown for treatment of neuropatichesky pain of peripheral or central origin at adults.
• Epilepsy. Drug is shown to adults as additional treatment in partial convulsive attacks with secondary generalization or without it.
• Generalized anxiety disorder. Drug is shown for treatment of a generalized anxiety disorder at adults.

Structure

Active ingredient: pregabalin.

1 capsule contains 75 mg or 150 mg or 300 mg of a pregabalin.

Excipients: lactose monohydrate, starch corn talc capsule cover: gelatin, the titan dioxide (E 171), patent blue V (E 131) (for capsules on 75 mg) gelatin, the titan dioxide (E 171) (for capsules on 150 mg) the titan dioxide (E 171), erythrosine (E 127), karmoizin (E 122), diamond blue FCF (E 133), gelatin (for capsules on 300 mg).

Contraindication

Hypersensitivity to active ingredient or to any of excipients.

Route of administration

to take the Drug irrespective of meal.

Range of doses of medicament can change within 150-600 mg a day. To distribute a daily dose on 2 or 3 receptions.

Feature

Pregnant women

Relevant data on use of a pregabalin to pregnant women are absent.

Safety and efficiency of the medicament Ligat at its use aged up to 18 years are not established to children by

.

Drivers

Pregabalin can have insignificant or moderate impact on ability to run vehicles and to work with mechanisms.

Overdose

After medicament entry into the market was reported that the most frequent side reactions at overdose of a pregabalin were drowsiness, confusion of consciousness, excitement and concern. Also messages about spasms arrived. It was seldom reported about coma cases.

Treatment of overdose of a pregabalin consists in the general supporting actions and if necessary can include a hemodialysis.

Side effects

Infection and invasion.

it is frequent: nasopharyngitis.

from blood and lymphatic system.

Infrequently: neutropenia.

from the immune system.

Infrequently: hypersensitivity. Seldom Quincke's disease, allergic reactions, anaphylactoid reactions.

Disbolism, metabolism.

it is frequent: increase in appetite. Infrequently loss of appetite, hypoglycemia.

from mentality.

it is frequent: euphoria, confusion of consciousness, irritability, disorientation, insomnia, decrease in a libido. Infrequently hallucinations, the panic attacks, concern, excitement, a depression, suppressed mood, high spirits, aggression, changes of mood, depersonalization, selection of words, pathological dreams, strengthening of a libido, an anorgazmiya, apathy is complicated. Disinhibition is rare.

from nervous system.

It is very frequent: dizziness, drowsiness, headache. Often ataxy, lack of coordination, tremor, dysarthtia, amnesia, memory impairment, disturbance of attention, paresthesia, hypesthesia, sedation, balance disturbance, lethargy.

Infrequently: faints, stupor, myoclonia, loss of consciousness, psychomotor hyperactivity, dyskinesia, postural dizziness, intentsionny tremor, nystagmus, disturbance of cognitive functions, mental disorders, speech disorders, hyporeflexia, hyperesthesia, burning sensation, ageusia, general malaise, apathy, circumoral paresthesias, myoclonus. Seldom spasms, parosmiya, hypokinesia, dysphagy, hypalgesia, dependence, cerebellar syndrome, syndrome of a cogwheel, lump, delirium, encephalopathy, extrapyramidal symptoms, syndrome to Giyena-Barra, intracranial hypertensia, maniacal reactions, paranoid reactions, sleep disorders.

from organs of sight.

it is frequent: illegibility of sight, diplopia, conjunctivitis. Infrequently loss of peripheral sight, a disorder of vision, an eye, defects of a field of vision, decrease in visual acuity, eye pain, an asthenopia, a photopsia, dryness in eyes, the raised dacryagogue, irritation of eyes, blepharitis, accommodation disturbances, a hematopsia, a photophobia, retina hypostasis swelled. Seldom loss of sight, keratitis, ostsillopsiya, change of visual perception of depth, mydriasis, strabismus, sight brightness, anisocoria, helcomas, exophthalmos, paralysis eye muscles, iritis, keratoconjunctivitis, miosis, night blindness, ophthalmoplegia, atrophy of an optic nerve, papilledema, ptosis, uveitis.

Interaction

mainly in not changed view with urine, tests insignificant metabolism in a human body (≤ 2% of a dose are allocated with urine in the form of metabolites), does not inhibit metabolism of other medicaments in vitro and does not contact proteins of blood plasma, it is improbable that pregabalin can cause pharmacokinetic interaction or to be object of such interaction.

to Store

in original packing out of children's reach.

Expiration date: 3 years.