Levofloxacin – synthetic antibacterial agent of group of ftorkhinolon, S-enantiomerom of racemic mix of medicine of an ofloksatsin is.

as antibacterial medicine from group of ftorkhinolon complex DNK-DNK-girazy and topoisomerase IV.

Indications

Infectious and inflammatory diseases easy and moderate severity, caused by microorganisms, sensitive to drug: the sharp sinusitis, exacerbations of chronic bronchitis, pneumonia complicated and uncomplicated infections of an urinary path (including pyelonephritises), infections of leather and soft tissues, chronic bacterial prostatitis.

Contraindication

Hypersensitivity to a levofloksatsin, other hinolona or to any of excipients. Epilepsy. Availability of complaints to side reactions from sinews after preliminary application of hinolon.

Route of administration and doses

to take the Drug 1 or 2 times a day irrespective of meal (it is possible to accept both together with food, and in other time). To swallow without chewing, washing down with enough liquid.

General dose depends on type and weight of an infection. Duration of treatment depends on the course of the disease. It is recommended to continue treatment levofloksatsiny within 48-72 hours after normalization of body temperature or the lack of activators confirmed with microbiological tests.

Overdose

According to results of researches on studying toxicity of medicine on animals or researches on studying clinical pharmacology which were carried out with use of supraterapevtichny doses, the most important signs which can be expected after sharp overdose of a levofloksatsin are symptoms from the central nervous system (CNS), such as confusion of consciousness, dizziness, violations of consciousness and convulsive attack and also lengthening of an interval of QT and gastrointestinal reactions, such as erosion of mucous membranes.

Within experience of use of medicine during the post-registration period in such cases observed effects from central nervous system, such as condition of confusion of consciousness, spasm, hallucination and tremor.

in case of overdose needs to perform symptomatic treatment. In view of possible lengthening of an interval of QT to carry out monitoring of indicators of the ECG. For protection of a mucous membrane of a stomach it is possible to use antacids. The hemodialysis, including peritoneal dialysis and chronic out-patient peritoneal dialysis, are not effective for removal of a levofloksatsin from an organism. Specific antidote to medicament does not exist.

Special instructions

Use during pregnancy or feeding by a breast

Due to a possibility of injury of an articulate cartilage by hinolona to the growing organism, it is contraindicated to use medicament pregnant and nursing. If during treatment the pregnancy is diagnosed, it is necessary to report about it to the doctor. Levofloxacin does not cause violations of fertility or reproductive function in rats.

Leflok is contraindicated to

for treatment of children because of the probability of injury of articulate cartilages.

Ability to influence speed of response at control of motor transport or other mechanisms

Such undesirable side reactions from nervous system as dizziness, drowsiness, disorders of vision and hearing break ability to concentrate attention and to react quickly therefore medicament should be used with care to patients who run vehicles or work with the mechanisms requiring special attention.

Structure

active ingredient: levofloxacin;

: a levofloksatsina of the gemigidrat in terms of levofloksitsin 250 mg or 500 mg;

excipients: microcrystalline cellulose, krospovidon, povidone, talc, magnesium stearate, gipromelloz, titan dioxide (E 171), macrogoal 4000, yellow decline of FCF (E 110).

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date – 3 years.