tablets Krestor are applied at the following indications:

• treatment of a hypercholesterolemia:
  • to adults, teenagers and children is more senior than 10 years with primary hypercholesterolemia (the IIa type, including with a heterozygous family hypercholesterolemia) or the mixed dislipidemiya (IIb type) as addition to a diet when observance of a diet and use of other non-medicament means (for example physical exercises, decrease in body weight) is insufficient;
  • at a homozygous family hypercholesterolemia as addition to a diet and other lipidosnizhayushchy remedies (for example an afereza ​​ LDL) or in cases when such treatment is inappropriate;
• prevention of cardiovascular disturbances: prevention to considerable cardiovascular disturbances at patients to whom, by estimates, the high risk of the first case of cardiovascular disturbance, in addition to correction of other risk factors threatens.

Structure

Active ingredient: rosuvastatin;

1 tablet, coated, 5 mg, 10 mg, 20 mg or 40 mg of rosuvastatin in the form of 5.20 mg, 10.40 mg, 20.80 mg 41.60 mg of rosuvastatin of calcium;

Excipients: lactose monohydrate, cellulose microcrystalline, calcium phosphate, krospovidon, magnesium stearate film cover: lactose monohydrate, a gipromelloza, glycerin triacetate, the titan dioxide (E 171), for tablets on 5 mg - ferrous oxide yellow (E172) for tablets on 10 mg, 20 mg, 40 mg - ferrous oxide red (E 172).

Contraindication

• to patients with hypersensitivity to rosuvastatin or any of medicine excipients;
• to patients with an active disease of a liver, including steady increases in serumal transaminases of an unknown etiology and any increases in transaminases in blood serum that three times exceed the upper bound of norm (UBN);
• to patients with a heavy renal failure (clearance of creatinine <30 ml/minute);
• to patients with a myopathy;
• to patients who at the same time receive cyclosporine;
• during pregnancy and feeding by a breast and also to women, reproductive age which do not use appropriate contraceptives.

Route of administration

Before an initiation of treatment a standard gipokholesterinemichesky diet to which he has to adhere also during treatment. The dose should be selected individually, depending on the purpose of therapy and the response of the patient to treatment, being guided by the recommendations of the current standard managements.

Krestor Medicine can be accepted at any time, irrespective of meal.

Feature of use

Pregnant

It is contraindicated.

medicine Use to children only the expert has to carry out

.

Drivers

With care.

Overdose

Specific treatment of overdose. In case of overdose of the patient it is necessary to treat symptomatic and in case of need to host the supporting actions. It is necessary to control functions of a liver and the UK levels. The efficiency of a hemodialysis is improbable.

Side effects

Undesirable phenomena which are noted at medicament Krestor use, usually easy and temporary. In controlled clinical trials less than 4% of the patients receiving Krestor left a research because of side reactions.

gave the most frequent undesirable reactions to rosuvastatin according to clinical trials and wide experience of postregistration use Below.

Endocrine disorders: frequent (from ≥ 1/100 to <1/10) - diabetes.

from nervous system: frequent (from ≥ 1/100 to <1/10) - a headache, dizziness.

from digestive tract: frequent (from ≥ 1/100 to <1/10) - a constipation, nausea, abdominal pain.

from skeletal muscles and connective tissue: frequent (from ≥ 1/100 to <1/10) - myalgia.

during combined use of Krestor medicine and cyclosporine AUC value of rosuvastatin were on average about 7 times higher than

, than those which were observed at healthy volunteers. Krestor is contraindicated to patients who at the same time receive cyclosporine.

Storage conditions

to Store

at a temperature not above 30 °C, out of children's reach.

Expiration date - 3 years.