Pharmacological properties

Pharmacodynamics. promestrin — the synthetic estrogenopodobny means intended for topical administration has local estrogenic effect on a mucous membrane of lower parts of an urogenialny path, restores their trophicity. at intravaginalny introduction has no systemic action therefore does not influence endometrium, mammary glands and a hypophysis.

Promestrin has local estrogenic impact on a mucous membrane of a vagina: promotes proliferation of a vaginal epithelium.

Pharmacokinetics. At intravaginalny use, medicament interacts with a vaginal secret, is split and its components are released. Promestrin does not kumulirutsya in fabrics, less than 1% of a promestrin, his T _{½ are soaked up} makes 24 h. At intravaginalny introduction promestrin has no resorptive effect, system hormonal effects are absent.

Indication

Vaginal atrophy caused by deficiency of estrogen. delay of healing of a vagina, neck of the uterus and vulva after the delivery, surgical intervention, physical therapy.

Use

Capsule. on 1 capsule which is (previously humidified) to enter deeply into a vagina within 20 days. in case of need treatment can be continued (a menopause, castration, use estrogen-progestinsoderzhashchikh of contraceptives).

Cream. To apply cream 1–2 times in every day 2–3 days.

Children. Do not apply.

Contraindication

Hypersensitivity to any component of drug. despite the lack of system effects, this medicament should not be used, as well as any estrogen, in estrogenzavisimy tumors (such as breast cancer, endometrium).

should not use Drug along with spermicidal means, latex condoms.

For medicament in the form of cream also: the endometriosis (diagnosed or suspected).

Side effects

from skin and hypodermic cellulose: very seldom — local reactions, including irritation, an itching, burning.

from the immune system: very seldom — allergic reactions.

Special instructions

during treatment should be under observation of the doctor.

At emergence of a metrorrhagia the reason and to carry out the supporting treatment.

If the doctor did not appoint other, daily vaginal washing is not obligatory, the external podmyvaniye water with soap is sufficient. In certain cases there can be reasonable a use of hygienic napkins.

Despite oiliness, the liquid which is contained in capsules is an emulsion and easily washes off.

Drug in the form of capsules contains sodium methylparaben (E219) and sodium propylparaben (E217) which can cause allergic reactions (sometimes delayed).

Use during pregnancy or feeding by a breast. Kolpotrofin is not shown for use during pregnancy. However results of numerous epidemiological researches show that, unlike diethylstulbestrole, use of estrogen at early stages of pregnancy is not followed by risk of developing of malformations. Thus in case of approach of pregnancy at use of medicine there is no need for its interruption.

When using condom the risk of its gap as the oily substances and lubricants as a part of capsules containing mineral oils reduce its durability exists.

Considering lack of sufficient data on penetration of medicament into breast milk, it is necessary to avoid its use during feeding by a breast.

Ability to influence speed of response at control of vehicles or other mechanisms. Data are absent.

Interaction

Drug can inactivate action of any spermicidal means therefore their simultaneous use is not recommended. medicament should not be used when using latex condom as the oily substances and lubricants containing mineral oils reduce its durability and increase gap probability.

Overdose

Considering a way of introduction and a low resorption of a promestrin, the system overdose is improbable.

However the overdose can be followed by strengthening of local side reactions (irritation, an itching, burning) in a vulva.

Therapy symptomatic.

Storage conditions

Capsule — at a temperature not above 25 °C, cream — does not demand special storage conditions.