tablets "Klaritromitsin-Zdorovye" it is applied at the following indications:

• Upper respiratory tract infection, that is nasopharynx (tonsillitis, pharyngitis), and infections of adnexal bosoms of a nose.
• Lower respiratory tract infection (bronchitis, acute lung fever and primary atypical pneumonia).
• Infection of leather and soft tissues (impetigo, folliculitis, erizipeloid, furunculosis, contaminated wounds).
• Acute and persistent dontogenous infections.
• Disseminated or localized mikobakterialny infections caused by Mycobacterium avium or Mycobacterium intracellulare. The localized infections caused by Mycobacterium chelonae, Mycobacterium fortuitum or Mycobacterium kansasii.
Eradikation's
• H. pylori at patients with a duodenum ulcer at oppression of secretion of hydrochloric acid (the activity of a klaritromitsin against H. pylori at neutral pH is higher, than at acid pH).

Structure

Active ingredient: clarithromycin.

1 tablet supports a klaritromitsin of 250 mg or 500 mg.

Excipients: starch corn, starch corn, magnesium stearate, silicon dioxide colloidal, talc, cellulose microcrystalline, sodium of a kroskarmelloz, sodium lauryl sulfate, gipromelloz, titan dioxide (E 171) dye: yellow decline of FCF (E 110) (dosage of 250 mg) or tartrazine (E 102) (dosage of 500 mg).

Contraindication

• Hypersensitivity to makrolidny antibiotics and to other components of medicine.
• Simultaneous application of a klaritromitsin and any of the following medicines: astemizol, tsizaprid, Pimozidum, terfenadin (it can lead to lengthening of an interval of QT and development of cardiac arrhythmias, including ventricular tachycardia, fibrillation of ventricles and torsades de pointes), ergot alkaloids, for example ergotamine, dihydroergotamine (it can lead to an ergotoksichnost), inhibitors of GMG-KoA-reduktazy (statines) that CYP3A4 are substantially metabolized (lovastatin or simvastatin), for increased risk of emergence of a myopathy, including a rhabdomyolysis.

Route of administration

Recommended dose of a klaritromitsin for adults and children is more senior than 12 years makes 250 mg each 12 hours, at heavier infections it is possible to increase a dose to 500 mg each 12 hours. The usual duration of treatment depends on severity of infection and is from 6 to 14 days.

can use Drug irrespective of meal as food does not affect bioavailability of a klaritromitsin.

Safety of application of a klaritromitsin during pregnancy and feeding by a breast is not established to

Feature

.

Children

to Children up to 12 years should be applied klaritromitsin in the form of suspension as application of tablets of a klaritromitsin to children of this age was not studied.

Drivers

Data on influence are absent.

Overdose

Symptoms. The existing messages indicate that the overdose klaritromitsiny can cause emergence of symptoms from digestive tract. At one patient with bipolar psychosis in the anamnesis, accepted 8 grams of a klaritromitsin, changes of an intellectual state, paranoid behavior, a hypopotassemia and an anoxemia developed.

Treatment. The side reactions accompanying overdoses it is necessary to treat by means of gastric lavage and symptomatic therapy. As well as in others of macroleads, it is improbable that the hemodialysis or peritoneal dialysis significantly influenced the maintenance of a klaritromitsin in blood serum.

Side effects

Infection and invasion: infrequently - cellulitis 1, candidiasis, a gastroenteritis 2, an infection 3, a vaginal infection; frequency is unknown - pseudomembranous colitis, erysipelatous inflammation.

from blood and lymphatic system: infrequently - a leukopenia, neytropeniya4, trombotsitemiya3, an eosinophilia 4; frequency is unknown - the Agranulocytosis, thrombocytopenia.

from the immune system: infrequently - anaphylactoid reaktsii1, hypersensitivity; frequency is unknown - anaphylactic reactions, a Quincke's disease.

from metabolism and food: infrequently - anorexia, a loss of appetite frequency is unknown - a hypoglycemia.

from mentality: often - insomnia infrequently - uneasiness, nervousness 3; frequency is unknown - psychoses, confusion of consciousness, depersonalization, a depression, a disorientation, hallucinations, dreadful dreams, a mania.

from central nervous system: often - a dysgeusia (violation of flavoring sensitivity), a headache infrequently - a loss of consciousness 1, diskineziya1, dizziness, drowsiness, a tremor frequency is unknown - spasms, an ageusia (loss of flavoring sensitivity), a parosmiya, an anosmia, paresthesias.

from organs of hearing and a labyrinth: infrequently - vertigo, deterioration in hearing, sonitus frequency is unknown - a hearing loss.

from heart: infrequently - cardiac arrest 1, fibrillation of auricles 1, lengthening of an interval of QT, premature ventricular contraction 1, heartbeat; frequency is unknown - torsades de pointes, ventricular tachycardia, fibrillation of ventricles.

from vessels: often - a vazodilatation 1; frequency is unknown - hemorrhage.

from the respiratory system, bodies of a thorax and mediastinum: infrequently - astma1, nasal krovotech 2, a vascular embolism legeniv1.

from digestive system: often - diarrhea, vomiting, dyspepsia, nausea, an abdominal pain infrequently - an esophagitis 1, gastroesophageal reflux bolezn2, gastritis, proktalgiya2, stomatitis, a glossitis, swelling zhivota4, a lock, dryness in a mouth, an eructation, a meteorism frequency is unknown - sharp pancreatitis, discoloration of language, discoloration of teeth.

from digestive system: often - an aberration of functional tests of a liver infrequently - holestaz4, gepatit4, increase in the ALT, nuclear Heating Plant, GGT4 level; frequency is unknown - a liver failure, hepatocellular jaundice.

from skin and hypodermic cellulose: often - rash, a hyperhidrosis; infrequently - violent dermatit1, an itch, urticaria, makulopapulezny rash 3; frequency is unknown - skin side reactions (for example, sharp generalized exanthematous pustulez, Stephens-Johnson's syndrome, a toxic epidermal necrolysis, the medicamentous skin reaction which is followed by an eosinophilia and system manifestations (DRESS)), an acne, Shenleyna-Genokh's disease.

from a musculoskeletal system and connective tissue: infrequently - muscular spasms 3, skeletal and muscular rigidity 1, mialgiya2; frequency is unknown - rabdomioliz2 **, a myopathy.

from kidneys and an urinary system: infrequently - increase in level of creatinine krovi1, increase in urea krovi1; frequency is unknown - a renal failure, interstitial nephrite.

General violations: infrequently - weakness 4, temperatura3, an adynamy, a stethalgia 4, oznob4, utomlennost4.

Laboratory researches: infrequently - change of a ratio albumine globulin1, increase in level of alkaline phosphatase in krovi4, increase in level of a lactate dehydrogenase in krovi4; frequency is unknown - increase in the Ministry of Emergency Situations, increase in a prothrombin time, urine discoloration.

about these voluntarily and the size of population of patients is not established, it is not always possible to establish precisely their frequency or a causal relationship with administration of drug. The general experience of application of a klaritromitsin makes more than 1000000000 patsiyento-days.

** In some messages about a rhabdomyolysis klaritromitsin it was appointed along with other medicines which are known that they are associated with a rhabdomyolysis (such as statines, fibrata, colchicine or Allopyrinolum).

1,2,3,4 Missile defense these side reactions it was reported only at use of medicine in shape: 1 - powder of the solution lyophilized for preparation for infusions, 2 - tablets of the prolonged action, 3 - suspensions, 4 - tablets of immediate release.

Interaction

Klaritromitsin does not interact with oral contraceptives.

to Store

in original packing at a temperature not above 25 °C. To store out of children's reach.

Expiration date: 3 years.