Tablets "Kardosal ^® plus 20/25" are used for treatment of essential hypertensia. The combined medicament is intended for adult patients at whom use of only one olmezartan of a medoksomil does not provide a lowering of arterial pressure to necessary level.

Structure

One tablet, coated, contains (active ingredients):

• an olmezartan - 20 mg;
• a hydrochlorothiazide - 25 mg.

Excipients: cellulose microcrystalline, the hydroxypropyl cellulose low-substituted, lactoses monohydrate, hydroxypropyl cellulose, magnesium stearate; cover: Opadry O2A22352 or O2A24576 (gipromelloza, talc, titan dioxide (E 171), ferrous oxide yellow (E172), ferrous oxide red (E 172)).

Contraindication

• allergic reaction (hypersensitivity) to active ingredients, to any of excipients or to other derivatives of streptocides (the hydrochlorothiazide also is derivative streptocides);
• heavy renal failures (clearance of creatinine <30 ml/minute);
hypopotassemia, a hypercalcemia, a hyponatremia and a clinically apparent hyperuricemia is resistant
• ;
• heavy abnormal liver functions, cholestasia and obstructive diseases of bilious ways;
• pregnancy or pregnancy planning;
to
• combined use of medicine "Kardosal ^® plus 20/25" and the medicaments containing aliskiren is contraindicated to patients with diabetes or a renal failure (SKF <60 ml/minute / 1.73 m ² ).

Route of administration

"Kardosal ^® plus 20/25" is not medicament of the first choice. It is intended for patients at whom use of only one olmezartan of a medoksomil in a dose of 20 mg does not provide the necessary level of arterial blood pressure.

Pill of medicament is taken 1 time a day irrespective of meal.

in the presence of clinical indications allows the translation of the patient from monotherapy of an olmezartan medical oxolovely in a dose of 20 mg on the combined medicament at once, however at the same time it is necessary to consider the fact that the maximum hypotensive action of an olmezartan of a medoksomil is reached in 8 weeks after an initiation of treatment. It is recommended by

to p of titration of a dose of each of components.

does not provide achievement of necessary level of arterial blood pressure.

Tablet entirely, washing down with enough liquid (for example a glass of water). Tablets should not be chewed. The medicament is recommended to be taken daily at the same time.

Feature of use

Pregnant

This medicament is contraindicated to the pregnant women or women planning pregnancy.

does not recommend to Apply medicine "Kardosal ^® plus 20/25" during feeding by a breast. At use of this medicament during feeding by a breast the dose has to be the lowest.

Safety and efficiency of use of this medicine are not established to children (aged up to 18 years) by

. Data are absent.

Drivers

Drug can cause insignificant or moderate influence on ability to run vehicles and to work with other mechanisms. Sometimes at the patients accepting antihypertensive medicaments the dizziness and increased fatigue can be observed owing to what reaction can decrease.

Overdose

Special information concerning symptoms or treatments of overdose by this medicament is absent.

For the patient carefully symptomatic supporting treatment. Symptomatic treatment also depends on time which passed from the moment of administration of medicament and on severity of symptoms.

Side effects

Most often at use of medicament arise such side reactions as a headache (2.9%), dizziness (1.9%), increased fatigue (1.0%).

Special storage conditions are not required for

. To store out of children's reach.

Expiration date - 5 years.