Kardonat the L-carnitine – amino acids and their derivatives.

Indications

• Primary (congenital) insufficiency of a carnitine.
• Secondary insufficiency of a carnitine.

Structure

• active ingredient: levocarnitine;
200 mg contain
• 1 ml of solution a left carnitine;
• other components: Natrium benzoicum (E 211), malic acid, sodium saccharin, Pineapple fragrance, the water purified.

Contraindication

Hypersensitivity to medicament components.

Side reactions

from nervous system – infrequently: headache. Frequency is unknown: sudorogi1, dizziness.

from heart – frequency is unknown: from heart consciousness.

from vessels – infrequently: arterial hypotension, arterial hypertension.

from the respiratory system, bodies of a thorax and mediastinum – frequency is unknown: asthma.

from digestive tract – it is frequent: nausea, vomiting, diarrhea, abdominal pain. Infrequently: a dysgeusia, dyspepsia, dryness in a mouth.

from skin and hypodermic fabric – infrequently: abnormal smell of a body. Frequency is unknown: itching, rash.

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for oral administration. Before use solution should be dissolved in a glass of water and to accept in 30 minutes prior to food. To use the dosing syringe or a measured glass to a dosage.

When using medicine it is reasonable to p to control levels of a free carnitine and acylcarnitine both in blood plasma, and in urine.

Dose and duration of treatment by a left carnitine are established by the doctor individually, depending on age, body weight and a nosological form of a disease of the patient.

Primary and secondary deficit of a carnitine

Dosage depends on specific congenital disbolism and weight of a condition of the patient during treatment.

generally, the recommended oral dose makes from 100 to 200 mg/kg/days

2–4 receptions, at less serious states the dose can be less (50–100 mk/kg/sut).

If clinical and biochemical signs do not improve, then the dose can be increased by the short period.

In acute metabolic disorders higher doses (up to 400 mg/kg/days) or intravenous administration of a left carnitine in a daily dose of 100 mg/kg can be required.

Secondary deficit of a carnitine at patients to whom carry out a hemodialysis.

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If achieved considerable clinical results after the first course of intravenous administration, it is possible to perform maintenance therapy in a dose of 1 g/days by oral administration. In day of dialysis the oral administration of medicine is made after the procedure.

Maximum daily dosage for adults makes 6 g (30 ml).

Use during pregnancy or feeding by a breast

Adequate clinical trials with participation of pregnant women were not carried out by

Feature of use

Levokarnitin – a usual component of human milk. Use of a left carnitine to the nursing mothers was not studied. During feeding by a breast medicine should be applied if the advantage of its use for the woman prevails the potential risk for the child caused by excessive exposure of a carnitine.

KARDONAT L-KARNITIN can apply

children (full-term and premature newborns) from first day of life.

Ability to influence speed of response at control of motor transport or other mechanisms

does not influence.

Overdose or prolonged use of a left carnitine can lead

to diarrhea. Levokarnitin easily leaves from blood plasma by dialysis.

Interaction with other medicines and other types of interactions

Cannot exclude interaction between a left carnitine and medicaments of coumarin. Seldom or never reported about increase in the international normalized relation (INR) at simultaneous use of a left carnitine with coumarin drugs. At simultaneous use of these means it is necessary to carry out monitoring of MNV or to carry out other tests for coagulation every week to stabilization and monthly further.

Simultaneous use of a left carnitine with the means inducing a gipokarnitinemiya because of strengthening of removal of a carnitine kidneys (for example, the valproic acid, pro-medicaments containing pivalonovy acid, cephalosporins, Cisplatinum, karboplatin, ifosfamid), can reduce its level.

to Store

at a temperature not over 25C.

to Store

out of children's reach.