Pharmacological properties

Pharmacodynamics. active ingredient of medicament (Mebicarum) on chemical structure is close to natural metabolites of an organism: the molecule of Mebicarum consists of two metilirovanny fragments of urea which are a part of bicyclic structure.

moderate tranquilizing (anxiolytic) activity, eliminates or weakens feeling of concern, uneasiness, fear, internal emotional pressure and irritation. The calming effect of medicament is not followed by muscle relaxation and a lack of coordination of movements. Drug does not reduce intellectual and physical activity therefore it can be applied during the working day or during training. Drug does not create high spirits, feeling of euphoria. On this basis Mebicarum _s is carried to day tranquilizers. Strengthens effect of sleeping medicines and improves a dream at its disturbance, but does not render somnolent effect.

Krom calming, medicament has nootropic effect. Drug improves cognitive functions, increases attention and intellectual working capacity, without stimulating symptomatology of productive psychopathological disorders, such as nonsense, pathological emotional activity.

Drug has antioxidant activity therefore works as a membranostabilizator, an adaptogen and a tserebroprotektor in an oxidative stress of various genesis.

activity of structures of a limbiko-reticular complex, in particular emotsiogenny zones of a hypothalamus and also influences all four main neuromediator systems — GAMK-ergichesky, cholinergic, serotonergic and adrenergic that promotes their balance and integration, but has no peripheral adrenonegativny effect. At a neuromediator profile of effect of medicament there is a dofaminpolozhitelny component. Drug shows antagonistic activity concerning excitement of adrenergic and glutamatergichesky systems and strengthens functioning brake serotonin - and GAMK-ergichesky mechanisms of a brain. Medicine has normosthenic properties.

Mebicarum _s facilitates nicotinic abstinency.

Pharmacokinetics. At oral administration the bioavailability is 77–80%; up to 40% of medicament contacts erythrocytes; other 60% do not contact blood proteins and contain in blood plasma in a stand-at-ease in this connection medicament widely spreads in an organism and gets through membranes. The C _max in blood plasma is reached in 30 min., high level remains during 3–4 h, then gradually decreases. Drug is completely removed from an organism with urine during 1 days, does not collect and is not subject to biochemical transformations in an organism.

Indication

Neurosises and neurosis-like states which are followed by irritation, emotional lability, feeling of alarm and fear; for improvement of shipping of neuroleptics or tranquilizers for the purpose of elimination of the somatovegetative and neurologic side effects caused by them; the cardialgias of various genesis (which are not connected with an ischemic heart disease); for simplification of a course of somatovegetative manifestations at a premenstrual syndrome and a menopause.

as a tserebroprotektor and an adaptogen in an emotional and oxidatic stress of various genesis.

as a part of complex therapy of nicotine addiction as the means reducing thirst for smoking.

Use

Drug is taken inside irrespective of meal. the dosage depends on specific features of the patient and the therapeutic purpose of use of medicine.

Tablet of 300 mg. The usual dose makes 300–600 mg 2–3 times a day. If necessary the dose can be raised. The maximum single dose — 3 g, the maximum daily dose — 10 g. Duration of a course of treatment — from several days to 2–3 months. As a part of complex treatment of nicotine addiction medicine 3 times a day during 5–6 weeks

Tablet of 500 mg. The usual dose for adults makes 500 mg 2–3 times a day, if necessary the dose can be raised. The maximum single dose — 3 g, daily — 10 g. Duration of a course of treatment — from several days to 2–3 months

At use as the means weakening dependence on tobacco smoking, medicament are appointed on 500–1000 mg by 3 times a day during 5–6 weeks

If one or several administrations of medicament are missed, it is necessary to continue a course of treatment according to earlier appointed scheme.

Contraindication

Individual sensitivity to medicament components.

Drug is usually well transferred by

.

from a cardiovascular system: seldom — decrease in the ABP.

from a digestive tract: seldom — dispeptic disorders (including nausea, vomiting). In that case it is necessary to lower a medicament dose.

from a respiratory system: seldom — a bronchospasm.

from skin and hypodermic cellulose: seldom — allergic reactions (including rash on skin, an itching, urticaria, a Quincke's disease). In case of allergic reaction the administration of medicament is stopped.

General disturbances: seldom — decrease in body temperature, weakness, dizziness. At decrease in the ABP and/or body temperature (body temperature can decrease by 1-1.5 °C) it is not necessary to stop administration of drug. ABP and body temperature are normalized independently.

Special instructions

With care needs to be applied in abnormal liver functions and kidneys, at patients with arterial hypotension. accustoming, dependence and a withdrawal at use of medicament are not established.

Use during pregnancy and feeding by a breast. Mebicarum _s well gets into all fabrics and liquids of an organism. Drug should not be used during pregnancy and feeding by a breast due to the lack of enough clinical data on use of medicament for this group of patients.

Children. Drug is not intended for use for children.

Ability to influence speed of response at control of vehicles or work with other mechanisms. It is necessary to be careful at control of vehicles as use of medicament can sometimes lead to decrease in the ABP.

Interaction

Mebicarum _s can be combined with neuroleptics, tranquilizers (benzodiazepines), hypnotic drugs, antidepressants and psychostimulants.

Overdose

Drug malotoksichen. at considerable overdose strengthening of side effects is possible (including allergic reactions, dispeptic disturbances, weakness, temporary decrease hell and body temperatures).

Treatment: it is necessary to carry out gastric lavage and the standard methods of desintoxication.

Storage conditions

In original packing at a temperature not above 25 °C.