Pharmacological properties

Diuretic, saluretichesky means. the mechanism of diuretic effect of medicament is caused by reduction of a reabsorption of ions of sodium and chlorine mainly in a proximal part of wavy tubules. it also oppresses a reabsorption of potassium and bicarbonates. the diuretic effect is shown in an alkalosis and acidosis and does not decrease at prolonged use of drug. has hypotensive properties (as a rule, at ag).

after intake. The diuretic effect develops during 1–2 h and proceeds up to 10–12 h and more.

Indication

Developments of stagnation in a small and big circle of blood circulation at cardiovascular insufficiency; cirrhosis with the phenomena of portal hypertensia; nefroza and nephrites (an exception — the severe progressing forms with reduction of glomerular filtration rate); toxicosis of pregnant women, a premenstrual syndrome (at developments of stagnation); ag, especially followed by a circulatory unefficiency (in a combination with other antihypertensives).

Pri to glaucoma (mainly subcompensated form) in some cases Hydrochlorthiazidum reduces intraocular pressure and normalizes intraocular tension (the effect occurs in 24–48 h). As a rule, intake of Hydrochlorthiazidum is combined with instillation in a conjunctival sac of miotik or other protivoglaukomny drugs.

Use

Inside in time or after a meal. the dose is established individually. the single and daily dose of medicament at its reception as diuretic can make 0.025-0.2 g accept once in the morning or in 2 receptions in the first half of day. increase in a dose more than 0.2 g is inexpedient (further strengthening of a diuresis is not observed). to elderly people with ag, followed by defeat of cerebral vessels, it is necessary to take the medicament in lower doses (0.0125 g 1–2 times a day).

can take the Drug within 3–7 days in a row and after a break for 3–4 days to continue administration of medicament again; if the condition of the patient allows a break in therapy is taken by each 1–2 days. Pri long-term treatment sometimes accept 2–3 times a week. Duration of a course of treatment and the general duration of reception depend on character and weight of pathological process, effect of therapy and tolerance of drug.

Pri AG is appointed on 0.025-0.05 g (1–2 tablets) a day, as a rule, as a part of complex therapy.

Pri to glaucoma the Profound renal failure, severe damages of a liver, a heavy course of diabetes and gout accept on 0.025 g/days

Contraindication

.

Side effects

Pri prolonged use the hypopotassemia (generally moderate) and a gipokhloremichesky alkalosis can develop. the hypopotassemia most often arises at patients with cirrhosis and nephrosis, a gipokhloremichesky alkalosis — at a saltless diet or loss of chlorides in vomiting or diarrhea.

Special instructions

against the background of the diet rich with potassium salts. apply to prevention of a hypopotassemia in combination with kaliysberegayushchy diuretics (these means and medicaments containing potassium are not appointed in diseases of kidneys). at a hypopotassemia appoint potassium asparaginate, chloride potassium solution (2 g/days), in case of a gipokhloremichesky alkalosis — sodium chloride.

Pri.

Storage conditions

In the dry place.