"Gepatsef komb" apply powder for solution for injections to treatment of the infections caused by microorganisms, sensitive to drug:

• respiratory infection (upper and lower parts);
• an infection of urinary tract (upper and lower parts);
• peritonitis, cholecystitis, cholangitis and other infections of an abdominal cavity;
• septicaemia;
• meningitis;
• an infection of leather and soft tissues;
• an infection of bones and joints;
• inflammatory diseases of bodies of a small pelvis, endometritises, gonorrhea and other infections of genitals.

Structure

1 bottle contains (active ingredients) of sterile mix of a tsefoperazon of sodium salt and a sulbaktam of sodium salt (1:1), in terms of tsefoperazon - 1.0 g and to sulbakta - 1.0 g

Contraindication

"Gepatsef of a komba" is contraindicated to patients with the known hypersensitivity to penicillin, a sulbaktam, a tsefoperazon or any cephalosporin.

Route of administration

"Gepatsef of a komba" (a combination of a sulbaktam of sodium / tsefoperazona sodium) is issued in bottles and is applied only parenterally.

in the form of dry powder for restoration in the ratio 1:1 in terms of free to sulbakta and tsefoperazon. Bottles with powder in the ratio 1:1 contain an equivalent of 1000 mg + 1000 mg of a sulbaktam and a tsefoperazon respectively.

Adult

Usual dose "Gepatsef of a komba" for adults makes 2-4 g a day (that is from 1st to 2 of a tsefoperazon a day) intravenously or intramusculary in evenly distributed doses each 12 hours.

In heavy or refractory infections a daily dose of the medicine "Gepatsef of a Komba" can be raised up to 8 (that is a dose of a tsefoperazon - 4 g) intravenously in evenly distributed doses each 12 hours. The recommended maximum daily dose of a sulbaktam makes 4 g (8 g of the medicine "Gepatsef of a Komba").

Children

Usual dose of the medicine "Gepatsef of a Komba" for children makes from 40 to 80 mg/kg/days (that is 20-40 mg tsefoperazona/kg/sutki), evenly distributed on 2-4 doses.

In heavy or refractory infections this dose can be raised to 160 mg/kg/days (80 mg tsefoperazona/kg/sutki), having evenly divided it into 2-4 doses.

Newborn the 1st week of life should enter medicine each 12 hours. The maximum daily dose of a sulbaktam at children should not exceed 80 mg/kg/days (160 mg/kg/days of the medicine "Gepatsef of a Komba"). In cases when the dose of a tsefoperazon which exceeds 80 mg/kg/days is necessary, the additional dose of a tsefoperazon should be applied separately.

Feature of application

Pregnant

"Gepatsef of a komba" can be applied during pregnancy only in the presence of accurate indications.

only a small part of the entered dose of a sulbaktam and a tsefoperazon gets Into breast milk. "Gepatsef" should appoint komb with care women who nurse in spite of the fact that components of medicine get into breast milk in insignificant quantity.

Drivers

Clinical experience of application of a sulbaktama/tsefoperazon gives the grounds to consider that influence on ability of the patient is improbable to steer motor transport or other mechanisms.

Overdose

Information on acute toxicity of a tsefoperazon of sodium and a sulbaktam of sodium at people insufficiently. It is expected that the overdose of medicine can cause manifestations which, mainly are strengthening of its side effects about which it was reported at use of medicine. It is necessary to take into account that high concentrations beta laktamnykh antibiotics in cerebrospinal fluid can cause neurologic reactions, including spasms. As tsefoperazon and to sulbakta are allocated from circulation by a hemodialysis, this procedure can strengthen removal of medicine from an organism in case of overdose at patients with a renal failure.

Side effects

from the system of blood and lymphatic system: very often (≥ 1/10) - a neutropenia, a leukopenia, direct positive test of Koombs, decrease in level of hemoglobin, decrease in level of a hematocrit, thrombocytopenia; often (≥ 1/100 - <1/10) - a coagulopathy, an eosinophilia.

from digestive tract: often (≥ 1/100 - <1/10) - diarrhea, nausea, vomiting.

from a gepatobiliardny system: very often (≥ 1/10) - increase in level of alaninaminotranspherase, increase in level of aspartate aminotransferase, increase in level of alkaline phosphatase of blood; often (≥ 1/100 - <1/10) - increase in level of bilirubin in blood.

Interaction

Solutions of the medicine "Gepatsef of a Komba" and aminoglycosides should not be mixed directly as between them there is a physical incompatibility.

as it is established that these substances are incompatible. However application of two-stage process of cultivation at which primary solvent is water for injections allows to avoid incompatibility at further cultivation by lactat Ringera solution.

as these substances are incompatible. However application of two-stage process of cultivation at which primary solvent is water for injections allows to avoid incompatibility at further cultivation of 2% chloride lidocaine solution.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 2 years.