tablets Gap Arth are applied at the following indications:

• Intra hepatic cholestasia at adults, including at patients with chronic hepatitis of various etiology and cirrhosis
• an intra hepatic cholestasia at pregnant women;
• depressive syndromes.

Structure

Active ingredient: ademetionin.

ademetionin 1.4-butandisulfonat - 760.0 mg, (that corresponds a cation of an ademetionin - 400 mg).

Excipients: microcrystalline cellulose, starch sodium (type A), silicon dioxide colloidal, magnesium stearate.

Contraindication

Hypersensitivity to active ingredient or to any excipient of drug.

Genetic defects influencing metioninovy a cycle and/or cause a homocystinuria and/or a gipergomotsisteinemiya (for example, insufficiency tsistationin beta synthases, defect of metabolism of _{12 vitamin B} ).

Route of administration

Recommended dose makes 10-25 mg/kg of body weight a day. The initial dose makes 800 mg/days (2 tablets), the general daily dose should not exceed 1600 mg (4 tablets).

Feature of use

Should control ammonia level at patients with a pretsirotichna or cirrhotic a giperammoniyemiya stage which apply tablets of an ademetionin.

Pregnant

in the course of clinical trials at women who were treated ademetioniny in the III trimester of pregnancy observed no side reactions. Ademetionin in I and II trimester of pregnancy it is necessary to apply only after careful assessment by the doctor of a ratio advantage for pregnant woman / risk to a fruit.

during feeding by a breast ademetionin can be applied only when the potential advantage of its use exceeds potential risk for the baby.

Safety and efficiency of use of an ademetionin are not established to children by

.

Drivers

some patients during therapy ademetioniny can have a dizziness. In such cases it is necessary to refrain from control of vehicles or work with other mechanisms before total disappearance of symptoms which can influence speed of response at the specified types of activity.

Overdose

it was Seldom reported about overdose cases ademetioniny. At overdose the doctors have to address in local poison control centers. Observation of the patient and the supporting treatment is generally recommended.

Side reactions

Most often at treatment ademetioniny it was reported about a headache, diarrhea and nausea.

by

about development of a serotoninovy syndrome in the patient who applied ademetionin against the background of reception of a klomipramin. Because of it though the possibility of interaction is supposed theoretically, it is necessary to apply with care ademetionin along with selective serotonin reuptake inhibitors, tricyclic antidepressants (such as klomipramin), the medicaments and vegetable means containing tryptophane.

Storage conditions

In original packing at a temperature not above 25 °C. To store out of children's reach.

Expiration date - 2 years.