Sofarm furosemide – the diuretic applied to treatment.

• hypostases in chronic stagnant heart failure (if treatment using diuretics is necessary);
• hypostases at HPN;
• hypostases at a nephrotic syndrome (if treatment using diuretics is necessary);
• an acute renal failure, including at pregnant women or during childbirth;
• hypostases in liver diseases (if necessary – for addition of treatment using antagonists of Aldosteronum);
• arterial hypertension.

Structure

• active ingredient: furosemide;
• 1 tablet contains furosemide 40 mg;
• other components: lactoses monohydrate, starch wheat, silicon dioxide colloidal anhydrous, magnesium stearate, talc.

Contraindication

• hypersensitivity to furosemide or to any of medicine excipients;
• an allergy to sulfonamides (for example, sulphonamide antibiotics or sulphonylurea) because of possible manifestation of cross sensitivity on furosemide;
• hypovolemia or dehydration;
• an anury or a renal failure (the clearance of creatinine is lower than 30 ml/min.), a renal failure with an anury if the therapeutic answer to furosemide is not observed;
• a renal failure as a result of poisoning with nephrotoxic or hepatotoxic drugs;
• heavy hypopotassemia;
• heavy hyponatremia;
• prekomatozny and the comas connected with hepatic encephalopathy;
• intoxication foxglove;
• accompanying use of medicaments of potassium or kaliysberegayushchy diuretics.

Side reactions

from blood and lymphatic system: aplastic anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, leukopenia, eosinophilia, haemo concentration.

messages about oppression of function of marrow Are available that demands the immediate termination of treatment by furosemide.

from the immune system: heavy anaphylactic or anaphylactoid reactions, seldom or never up to shock, aggravation or activation of a system lupus erythematosus.

from nervous system: the paresthesias, nonsense, a giperosmolyarny coma, dizziness, a syncope and a loss of consciousness (caused by symptomatic hypotension).

from organs of sight: disorder of vision.

from organs of hearing and a labyrinth: noise or a ring in ears, a hearing disorder. Usually passing. Are more often shown at patients with a renal failure, a hypoproteinemia (at a nephrotic syndrome), as well as at fast administration of furosemide.

It was reported about deafness cases, sometimes irreversible, after oral administration or intravenous administration of furosemide.

from a cardiovascular system: arterial hypotension (in more hard cases proceeds with symptoms of the lowered concentration and the slowed-down reactions, dizziness, feeling of pressure in the head, a headache, drowsiness, weakness, dryness in a mouth), orthostatic hypotension (orthostatic. Tendency to fibrinferments, vasculites.

General disturbances: fever, fatigue, indisposition.

Furosemide to accept

inside usually at meal time or on an empty stomach.

Mode of a dosage is set by the doctor individually according to the therapeutic answer of the patient, applying a minimal effective dose. It is possible to apply once a day or every other day.

Recommended initial single dose makes 40 mg. Additional dose adjustment before achievement of a maintenance dose can be required. At mild cases the dose of 40 mg every other day can be sufficient. In cases of resistant hypostases the usual daily dosage makes 80 mg and more, 1 or 2 times a day, or to apply if necessary. At the serious conditions caused by hypostases the gradual increase in a dose up to 600 mg/days

can be required

Maximum daily dose of furosemide should not exceed 1500 mg.

Feature of use

Use during pregnancy or feeding by a breast

Furosemide gets through a placental barrier. It is not necessary to appoint it during pregnancy, except for cases of performing treatment according to vital indications. Treatment by furosemide during pregnancy demands monitoring of growth and fetation.

Furosemide gets into breast milk and can inhibit a lactation. Women should stop feeding by a breast during treatment by furosemide.

Children

For children a dose needs to be reduced according to body weight.

For children who cannot take a dosage form for oral administration for example of premature children and newborns, it is necessary to consider the possibility of use of a form for parenteral administration.

Ability to influence speed of response at control of motor transport or other mechanisms

Furosemide reduces concentration of attention and can cause disturbance of ability to run vehicles and also during the work with cars. At furosemide use some side effects (for example, unexpected considerable decrease in the ABP) can break ability of the patient to concentration of attention and speed of its reaction.

Therefore for treatment should refrain from driving of motor transport or work with other mechanisms.

Overdose

Clinical picture

In acute or chronic form the overdose depends generally on degree and consequences of loss of electrolytes and liquids and is shown as the hypovolemia, dehydration, haemo concentration, cardiac arrhythmias (including AV blockade and fibrillation of ventricles) caused by a profound diuresis. At furosemide overdose which is most often shown by the heavy arterial hypotension (progressing to shock), cardiac arrhythmia, orthostatic collapse or other signs of a hypovolemia (an acute renal failure, thrombosis, delirious states, absurdity, peripheral couple.

Should stop immediately treatment and if necessary to enter solution of electrolytes for restoration of circulator volume and water and electrolytic balance. Due to the prevention and treatment of these disturbances the intensive treatment and control of a condition of the patient can be required. Right after absorption of medicine with the purpose to limit system absorption of active agent, to carry out gastric lavage and to apply activated carbon.

Specific antidote. Therapy is symptomatic.

to Store

out of children's reach.

to Store

in original packing at a temperature not above 25 °C.