Frontline Combo (Frontline of the Combo) of by Merial - Antiparasitic drops from fleas and ticks for dogs

Antiparasitic drops of Frontline by Merial - Frontline COMBO belong to the combined insektoakaritsidny medicines of contact action. Possess the expressed contact insect-acaricidal action, medicine is active concerning preimaginalny and imaginal phases of development of the louses, fleas, vlasoyed and ticks (ixodic, heylitella) parasitizing on dogs. The mechanism of action of a fipronil consists in blocking GAMK-zavisimykh (GAMK-gammaaminomaslyanaya acid) receptors of parasites, violation of transfer of nervous impulses that leads to paralysis and death of ektoparazit. S-metopren inhibits the juvenile hormone promoting formation of chitin, breaking thereby, development of a flea at a stage of egg and a larva. When drawing on skin medicine is not soaked up, and gradually, within 24 hours, being distributed on the surface of a body and, is reserved in sebaceous glands, has long insect-acaricidal effect in places of localization of ektoparazit.

Advantages:

• Frontline COMBO is medicine against external parasites (insecticides / acaricides) for dogs.
• one Frontline COMBO pipette Suffices every month.
• Medicine kills fleas and ticks.
• Frontline COMBO reliable protection against the diseases transferred by pincers.
• Frontline COMBO kills not only adult fleas, but also their egg and a larva.
• Reliable protection for dogs.
• Proved safety for the growing, pregnant and feeding animals.
• Frontline COMBO one of the medicines which are most recommended by veterinarians.

Structure: Active active ingredients:

• Frontline COMBO Drops for dogs weighing 2-10 kg
• 1 0.67 ml pipette:
  • fipronit - 9.8%,
  • S-metopren - 8.8%.
• Frontline COMBO Drops for dogs weighing 10-20 kg
• 1 1.34 ml pipette:
  • fipronit - 9.8%
  • S-metopren - 8.8%.
• Frontline COMBO Drops for dogs weighing 20-40 kg
• 1 2.68 ml pipette:
  • fipronit - 9.8%
  • S-metopren - 8.8%
• Frontline COMBO Drops for dogs weighing 40-60 kg
• 1 4.02 ml pipette:
  • fipronit - 9.8%,
  • S-metopren - 8.8%.

Excipients:

• polividon,
• polysorbate.

release Form:

• Dosage form: solution for external application.
• Frontline COMBO is drops on withers.
• On appearance of Frontline COMBO represents colourless transparent liquid, with a slight specific smell.
• Produce medicine packaged in polyethylene pipettes.
• Polyethylene pipettes of the corresponding volume with the breaking-off tip.
• Polyethylene pipettes, are placed by the piece in blisters together with the instruction for application.

Pharmacological properties:

• Frontline COMBO belongs to the combined insektoakaritsidny medicines of contact action.
• Frontline COMBO is active in the relation:
  • fleas (mature and preimaginalny phases of development) of Ctenocephalides spp.,
  • vlasoyed of Felicola subrostratus, Trichodectes canis,
  • ixodic pincers (all phases of development) of Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Ixodes holocyclus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata, Haemaphysalis leachi, Amblyomma americanum,
  • Aedes aegypti mosquitoes,
  • sarkoptoidny pincers of Sarcoptes scabiei var. canis.
• Fipronil - insektoakaritsid groups of fenilpirazol, the mechanism of its contact action consists in blocking GAMK-zavisimykh of receptors of arthropods, violation of transfer of nervous impulses that leads to paralysis and death of ektoparazit.
• S-metopren is an analog of juvenile hormone, the regulator of growth of insects; breaking chitin synthesis, causes anomalies of development of insects at a stage of egg and a larva, prevents appearance of mature insects on animals and in places of their contents.
• After drawing on skin active ingredients are gradually distributed on all surface of a body of an animal within 24 hours, practically without being soaked up in a system blood-groove, collect in epidermis, hair bulbs and sebaceous glands, have long contact effect, providing protection of an animal against ektoparazit.
• Single processing of an animal provides extermination of fleas and ticks within 24 and 48 hours, respectively.
• Protective effect of medicine:
  • against ixodic pincers proceeds up to 4 weeks,
  • against mature and preimaginalny phases of development of insects up to 4 - 12 weeks.
• Frontline COMBO on extent of impact on an organism belongs to substances moderately dangerous, in the recommended doses, does not render the kozhnorezorbtivny, sensibilizing, embriotoksichesky, teratogenny and mutagen action.
• At hit in eyes causes weak irritation.

Indication:

• Frontline COMBO is appointed to dogs for treatment and prevention:
  • entomoz caused by fleas, louses and vlasoyeda
  • akaroz caused by ixodic pincers
  • in complex therapy of the allergic dermatitis caused by fleas
  • for prevention of attachment and development of ektoparazit on animals.
• Frontline COMBO can be applied to treatment and prevention at pregnant women and the lactating animals.
• Frontline COMBO should not be applied together with other insektoakaritsidny means to processing of animals.

Method of application:

1. Frontline COMBO apply an animal once by drawing drops on the dry uninjured skin, using pipettes of various packing.
2. Before processing of an animal preperaty Frontline COMBO:
   • at the pipette break off a tip,
   • move apart at an animal wool in a back (between shovels),
   • pressing the pipette, apply medicine to skin in one or several points.
3. Protective effect of medicine:
   • against ixodic pincers at dogs not less than 1 month,
   • against an imago of insects up to 3 months,
   • from preimaginalny phases of development of insects up to 8 months.
4. At strong defeat of an animal louses, fleas, vlasoyeda, it is recommended to make processing once a month.
5. If the animal is washed more often than 2 times a month it is recommended to reduce an interval between processings to 3 weeks.
6. it is not recommended:
   • wash and bathe animals with detergents,
   • allow animals in natural reservoirs within 48 hours after processing,
   • apply medicine to the moist or injured skin.
7. For prevention of a repeated infestation of animals the fleas recommend:
   • process all animal, living in common,
   • replace laying or to process them insecticide according to the instruction for its application.
8. Features of effect of medicine at its first application and cancellation are not revealed.
9. On hair of an animal the damp or oil spot for 24 hours after putting medicine can be noted.
10. It is necessary to avoid violations of the scheme of use of medicine as it can lead to decrease in its efficiency.
11. in case of the admission of the next processing it should be carried out as soon as possible in the same dose.

Dosage:

• Volume of Frontline COMBO pipettes is designed for dogs of different weight categories, according to the table:

Mass of an animal	Volume of the used pipette and designation on packing	Content of active ingredients is to 1 pipette
		Fipronil, mg	S-metoprena, mg
2-10 kg	0.67 ml (S)	67.0	60.3
10-20 kg	1.34 ml (M)	134.0	120.6
20-40 kg	2.68 ml (L)	268.0	241.2
40-60 kg	4.02 ml (XL)	402.0	361.8

• For processing of dogs which weight more than 60 kg, use a combination of pipettes of different volume at the rate of 0.067 ml/kg.

Side effects:

• At use of medicine according to the present instruction of by-effects and complications at animals, as a rule, it is not observed.
• It is very rare on the place of putting medicine:
  • it is possible, wool pasting,
  • poorly expressed skin reaction (an itch, wool loss, skin reddening),
  • at medicine hit inside - excessive salivation.
• At the increased individual sensitivity and emergence of allergic reactions medicine should be washed away water with detergent and if necessary on recommendations of the veterinarian appoint antihistaminic medicines.
• Frontline COMBO should not be applied together with other insektoakaritsidny means to processing of animals.
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• At overdose at an animal the excess salivation, a muscular shiver, vomiting can be observed.
• At overdose of Frontline COMBO medicine is washed away water with detergent, after consultation with the veterinarian appoint to an animal antihistaminic medicines and means of symptomatic therapy.

Contraindications:

• puppies of 8 weeks age, dogs weighing less than 2 kg Cannot apply.
• not to apply the patient with infectious diseases and the weakened animal.
• Increased individual sensitivity of an animal to medicine components.
• At individual allergies to medicine components, stop its use, wash up a dog and consult with the veterinarian concerning prescribing of antihistamines.

Measure of personal prevention:

• When holding treatment-and-prophylactic actions with use Frontline COMBO it is necessary to use rubber gloves.
• In operating time it is not allowed to smoke, drink and eat food.
• Upon termination of work it is necessary to wash up carefully hands warm water with soap, to wash up and dry gloves.
• Within 24 hours after processing the animal should not be ironed and admitted to small children.
• it is not necessary to allow to work with medicine of persons with symptoms of allergic, respiratory and skin diseases.
• People with hypersensitivity to components of medicine need to avoid direct contact with Frontline COMBO .
• At accidental hit of medicine on skin or mucous membranes of eyes they need to be washed out a large amount of water.
• in case of manifestation of allergic reactions or at accidental hit of medicine in a human body it is necessary to address to medical institution (at itself to have the instruction for application or the label) immediately.
• use of empty pipettes from under medicine for the household purposes Is forbidden. y are placed in a cellophane package and utilized with household waste.

Storage:

• Conditions hranen iya with precaution according to list B.
• Store medicine in the closed packing of the producer.
• Store medicine separately from foodstuff and forages.
• Store medicine in the place protected from direct sunshine.
• Store medicine at a temperature from 0 °C to 30 °C.
• Frontline COMBO should be stored in the place, inaccessible for children.
• Unused medicine is utilized according to requirements of the legislation.

Expiration date: Medicine at observance of storage conditions - 3 years from the date of production. It is forbidden to use medicine after an expiration date.
Packing: 10-20 kg, 2-10 kg, 20-40 kg, 40-60 kg.
Producer: Frontline by Merial, Boehringer Ingelheim International GmbH, France. Species of an animalDogsFormDrops on withersProtection fromFleas
Vlasoyeda
Ixodic pincers
Pincers
Mosquitoes
Larvae of fleasBasic operating with the Eastern Military DistrictFipronil
MetoprenSpecies of parasitesExternal parasitesapplication TypeFor external applicationApplication is authorized to the Louse
of 2 monthsAge of an animalAdult animals
growth Period (till 1 year)