Folic acid – antianemic means. Folic acid and its derivatives.

Indications

Macrocytic anemias, in particular, megaloblastny anemias at pregnant women; for treatment to a spr for the purpose of normalization of a hematopoiesis, elimination or reduction of clinical manifestations of a disease. The anemias and leukopenias caused by the ionizing radiation, chemicals, including medicine; the anemias which arose owing to a resection of a stomach or a part of intestines, the megaloblastny anemias caused by tuberculosis of intestines and a chronic gastroenteritis (in these diseases are shown also without development of anemia), pernicious anemias, a pellagra.

Deficiency of folic acid connected with unbalanced or unsatisfactory food.

As supportive application in depressions and a syndrome of the increased uneasiness; at treatment of a dysplasia of a neck of the uterus.

Structure

• active ingredient: folic acid;
• 1 tablet contains folic acid 1 mg;
• other components: glucose monohydrate, stearic acid.

Contraindication

Hypersensitivity to folic acid or components of drug, deficiency of B12 vitamin, malignant new growths, malignant anemias, not treated deficiency of cobalamine.

Side reactions

Drug is well transferred by

.

• from a digestive tract: seldom – nausea, vomiting, an abdominal distension, a meteorism, feeling of bitterness, it is very rare – anorexia;
• from the immune system: seldom – allergic reactions, including skin rash, an erythema, a small tortoiseshell, an itching and disorders of breath as a result of a bronchospasm, arterial hypotonia, anaphylactic reactions;
• from the central nervous system: fever, sleep disorder, spasms;
• from an urinary system: a hypertrophy of epithelial cells in tubules of kidneys and disturbance of their functions.

Route of administration

Folic acid to accept

inside after a meal.

Dosage and duration of treatment defines

doctor depending on character and the course of a disease.

medicament to appoint

In the medical purposes the adult on 1-2 mg (1-2 tablets) 1-3 times a day.

For prevention of the deficiency of folic acid connected with unbalanced or unsatisfactory food – 1-5 mg (1-5 tablets) a day. A course of treatment – 20-30 days.

In 1 month a course of treatment is recommended to be repeated.

to Children of 3 years, depending on age of the child and the nature of a disease to appoint medicament by

on 1 mg (1 tablet) 1-2 times a day. The maximum daily dose – 2 mg (2 tablets).

Usual course of treatment makes 20-30 days.

by

Pregnant at the lowered hemoglobin level in the I trimester of pregnancy folic acid to appoint in a dose 4 mg/days in a combination with iron preparations within 3 months. Then to reduce a dose of folic acid to 4 mg once a week.

Drug to appoint

Feature of use by

with care to patients with anemias of an unspecified etiology as folic acid can prevent diagnosis of malignant anemia by improvement of hematologic manifestations of a disease, allowing to progress neurologic complications.

Use during pregnancy or feeding by a breast Deficiency of folic acid or disturbance of metabolism of folic acid connect

by

with emergence of congenital defects and some defects of a neurotubule. Intervention in metabolism of folic acid or deficiency of folic acid owing to effect of some medicines, for example anticonvulsant, antineoplastic drugs, in the early stages of pregnancy, leads to congenital anomalies. The lack of vitamin or its metabolites can influence a misbirth and a delay of pre-natal development also.

In the medical purposes can use medicament on doctor's orders, in the doses and duration specified in the instruction.

to

Children

to

medicament use Is contraindicated to children up to 3 years.

Ability to influence speed of response at control of motor transport or other mechanisms

Is not present data on negative impact of folic acid on ability to operate transport mechanisms.

Overdose

Symptoms: The overdose of folic acid can mask deficiency of B12 vitamin.

Long and considerable exceeding the recommended doses can cause dangerous accumulation of crystals of Folacinum that leads to intoxication of an organism and strengthening of side effects.

Treatment: medicament withdrawal, symptomatic therapy.

Interaction with other medicines and other types of interactions

At patients with deficiency of folate the use of folic acid can reduce the level of phenobarbital, Phenytoinum and Primidonum in blood plasma and to cause an epileptic attack.

Oral contraceptives, ethanol, Sulfasalazinum, Cycloserinum, glyutetimid and a methotrexate can affect folate metabolism.

Acetylsalicylic acid can increase elimination of folic acid. Folates increase efficiency of lithium. Nitrous oxide can cause acute shortage of folic acid.

Deficiency of folic acid such medicines as antitubercular drugs, antagonists of folic acid, such as Pyrimethaminum, Triamterenum, Trimethoprimum can cause

.

Digestion of folic acid decreases at simultaneous use with analgetics, anticonvulsant drugs.

Folic acid can reduce absorption of zinc in intestines.

Cannot be applied together with mineral acids, alkaline substances.

Storage conditions

to Store

in original packing at a temperature not over 25C.

to Store

out of children's reach.