Ticks treat the most hardy organisms. Their ability to slow down own metabolism allows them to do a long time without food (to adult individuals - up to two years) at all stages of development, and females of certain species of ticks are capable to breed without fertilization. Therefore extermination of some adult individuals does not give full disposal of ticks who become carriers of infectious diseases and are the reason of the dermatitis which is hard transferred by an animal.
Appeal of the medicine Fiprist Kombo is existence not only a fipronil who completely kills adult individuals of ektoparazit, but also existence (S) - a metopren who breaks synthesis of chitin and leads of not mature individuals to death.

Primeneniye Fiprist of a combo allows to fight and carry out effectively prevention at infection of an ektoparazitama of cats and polecats, namely:

• are interfered fixing and reproduction of ektoparazit on cats and polecats
• by prevention caused by louses, by vlasoyeda and fleas of the entomoz which are followed by an itch, itch and loss of wool
• prevention of the akaroz caused in the animals ixodic pincers who are followed by a severe itch and inflammatory processes on an integument

Medicine is executed in the form of convenient for drawing - drops on withers, packaged in pipettes with a medicine dosage on one application. Single use of medicine provides protection of an animal for a period of up to four weeks from pincers, fleas, vlasoyed. Repeated use of medicine is recommended not to a wound than in 4 weeks. When using this medicine for fight against ektoparazita the change and processing of laying is also recommended, cages, carryings, vacation spots of animals

Before use of medicine it is necessary to study carefully the instruction and to consult with the veterinarian.


Instruction for use of the medicine Fiprist Kombo®
release Form, structure and packing
Solution for external application (for cats and polecats) transparent, yellow color.

1 ml
fipronit
	100 mg
S-metopren	120 mg

Excipients: K25, polysorbate 80, butylhydroxyanisole (E320), butilgidroksitoluyen is seen (E321), ethanol, monoethyl air of diethylene glycol.
packaged on 0.5 ml in the polyethylene pipettes of the corresponding volume placed by the piece in packages from aluminum foil. Packages of pipettes are packed by the piece into cardboard boxes. Each packing is supplied with the instruction for application.

Pharmacological (biological) properties and effects
Combined insektoakaritsidny medicine of contact action. Contains in quality of active ingredients fipronit also S-metopren.
Fipronil - insektoakaritsid groups of fenilpirazol, the mechanism of contact action consists in blocking GAMK-zavisimykh of receptors of arthropods, violation of transfer of nervous impulses that leads to paralysis and death of ektoparazit.
(S) - metopren - an analog of juvenile hormone, the regulator of growth of insects; breaking chitin synthesis, causes anomalies of development of insects at a stage of egg and a larva, prevents appearance of mature insects on animals and in places of their contents.
Fiprist® of the Combo is active concerning fleas (mature and preimaginalny phases of development) of Ctenocephalides spp.; vlasoyed of Felicola subrostratus, Trichodectes canis; ixodic pincers (all phases of development) of Dermacentor variabilis, Rhipicephalus sanguineus, Ixodes scapularis, lxodes ricinus, Ixodes holocyclus, Haemaphysalis longicornis, Haemaphysalis flava, Haemaphysalis campanulata, Haemaphysalis leachi, Amblyomma americanum; Aedes aegypti mosquitoes; sarkoptoidny pincers of Sarcoptes scabiei var. canis.
After drawing on skin active ingredients are gradually distributed on all surface of a body of an animal during 24 h, practically without being soaked up in a system blood-groove, collect in epidermis, hair bulbs and sebaceous glands, have long contact effect, providing protection of an animal against ektoparazit. Single processing of an animal provides to
extermination of fleas and ticks during 24 and 48 h respectively. Protective effect of medicine against ixodic pincers continues at cats, dogs and polecats - up to 4 weeks; against mature and preimaginalny phases of development of insects in cats and polecats - up to 6 weeks, at dogs - up to 12 weeks.
Fiprist® of the Combo on extent of impact on an organism belongs to substances moderately dangerous (the 3rd hazard class in accordance with GOST 12.1.007-76), in the recommended doses does not render local irritative, resorptive and toxic, embriotoksichesky and teratogenny action, at hit in eyes causes weak irritation. Medicine is toxic for rabbits and also fishes and other hydrobionts.

Indication to use of the medicine Fiprist® of the Combo:
Fiprist® of the Combo is appointed to dogs, cats and polecats:
— for treatment and prevention of the entomoz caused by fleas, louses and vlasoyeda;
— for treatment and prevention of the akaroz caused by ixodic pincers;
— in complex therapy of the allergic dermatitis caused by fleas;
— for prevention of attachment and development of ektoparazit on animals.

an application Order apply
Fiprist® of the Combo an animal once by topikalny drawing (a spot - it) on the dry uninjured skin, using pipettes of various packing. Before processing the tip of the pipette is punctured with the turned cap, move apart at an animal wool in a back (between shovels) and, pressing the pipette, apply medicine to skin in the field of withers in one or several points in the minimum dose of 0.067 ml/kg, according to the table.

Species of an animal and weight (kg)	Volume of the pipette (ml)	Content of active ingredients in 1 pipette
		Fipronil (mg)	S-metopren (mg)
Dog
> 2 ≤10	0.67	67	60.3
> 10 ≤20	1.34	134	120.6
> 20 ≤40	2.68	268	241.2
> 40 ≤60	4.02	402	361.8
Cat, polecats	0.5 ml	50	60

For processing of dogs which weight more than 60 kg, use a combination of pipettes of different volume.
apply Medicine to an animal on the area of a body inaccessible for a slizyvaniye, avoiding contact of medicine with eyes. The living in common animal are supported separately before full drying of medicine.
carry out Repeated processings of animals according to indications, but is not more often than 1 time in 4 weeks. For prevention of a repeated infestation of animals the fleas recommend to process at the same time all the animals living in common and also to replace laying or to process them insecticide according to the instruction for its application.
Features of effect of medicine at the first application and cancellation is not revealed. On hair of an animal the damp or oil spot for 24 h after putting medicine can be noted.
It is necessary to avoid violations of the scheme of use of medicine since it can lead to decrease in its efficiency. In case of the admission of the next processing it should be carried out as soon as possible in the same dose.

Side effects At use of medicine according to the instruction of by-effects and complications at animals. Very seldom on the place of putting medicine the wool pasting, poorly expressed skin reaction (an itch, wool loss, skin reddening) is possible, at medicine hit inside - excessive salivation.
At the increased individual sensitivity and emergence of allergic reactions medicine should be washed away water with detergent and if necessary to appoint antihistaminic medicines.
At overdose of medicine at an animal can be observed excess salivation, a muscular shiver, vomiting. In this case medicine is washed away water with detergent and appoint to an animal antihistaminic medicines and means of symptomatic therapy.

Contraindication to use of the medicine Fiprist® of the Combo:
.

forbidden application of Fiprist® of the Combo:
— the patient with infectious diseases and the weakened animal;
— to puppies and kittens is younger than 8 weeks age;
— to dogs weighing less than 2 kg;
— to kittens weighing less than 1 kg;
— to polecats age less than 6 months

Special indications and measures of personal prevention
Fiprist® of the Combo should not be applied together with other insektoakaritsidny means to processing of animals.
should not wash animals with detergents, to allow them in natural reservoirs during 48 h after processing and also to apply medicine to the moist or injured skin. Medicine the pregnant and lactating boughs and pregnant cats can apply
. Medicine is not recommended to be applied to the lactating cats with kittens more young than 8 weeks age. There is no use of medicine given about safety to the lactating and pregnant females of polecats therefore medicine to this group of animals is applied under control of the veterinarian.
Fiprist® of the Combo is not intended for processing of productive animals.

Measure of personal prevention
When holding treatment-and-prophylactic actions with use of the medicine Fiprist® of the Combo should use rubber gloves. In operating time it is not allowed to smoke, drink and eat food. On completion of work it is necessary to wash up carefully hands warm water with soap, to wash up and dry gloves.
During 24 h after processing should not iron and admit an animal to small children.
People with hypersensitivity to a fipronil and S-metoprenu should avoid direct contact with the Combo medicine Fiprist®.
At accidental hit of medicine on skin or mucous membranes of his eyes needs to be washed away immediately a large amount of flowing water with soap. In case of manifestation of allergic reactions and/or at accidental hit of medicine in a human body it is necessary to address to medical institution (at itself to have the instruction for application or the label) immediately.
Empty package from under medicine is subject to utilization with household waste.

Storage conditions of Fiprist® of the Combo
Medicine should be stored in the closed original packing, separately from foodstuff and forages, in protected from direct sunshine, the place, inaccessible for children, at a temperature from 0 °C to 25 °C.
utilize Unused medicine according to requirements of the legislation.

Expiration date of Fiprist® of the Combo
Expiration date at observance of storage conditions - 2 years from the date of production. Use of medicine after an expiration date is forbidden.
release Form: monopipette with a single dose of medicine, packaging on 1 piece / unitary enterprise., 3 pieces / unitary enterprise.

Packing: 3 pieces / unitary enterprise.
Producer : Fiprist of the Combo, KRKA d.d., Novo Mesto (Slovenia) Species of an animalCatsSpecies of rodentsPolecatsFormDrops on withersProtection fromFleas
Vlasoyeda
Ixodic pincers
Pincers
Larvae of fleas
Scabby pincersBasic operating with the Eastern Military DistrictFipronil
MetoprenSpecies of parasitesExternal parasitesapplication TypeFor external applicationApplication is authorized to the Louse
of 2 months
of 6 months
from 1 kg of weight
from 2 kg of weightAge of an animalAdult animals
growth Period (till 1 year)