Indications:
In bronchial asthma: prevention and stopping of a bronchospasm, as the making component at complex treatment of bronchial asthma (including asthmatic status). With the preventive purpose apply just before contact with allergen or before physical activity. Ventolin is applied also at a chronic obstructive pulmonary disease which is followed by reversible obstruction of bronchial tubes.


Route of administration:
Ventolin Nebula. Drug is not intended for injections. It is entered in the inhalation way by means of the nebulizer with a mask, an endotracheal or T-shaped tube. At hypoventilation there can be a risk of a hypoxia, then the inhaled air can be enriched with oxygen. Ventolin of Nebula is applied without cultivation, but in need of long inhalation (Bol ten minutes), medicine can be dissolved sterile 0.9% with sodium chloride solution.
Drug should be used in well aired rooms as a part of medicine at inhalation gets to the environment. Especially it is important in the conditions of a hospital where several patients can use nebulizers at the same time.
Initial dose of Ventolin at inhalation introduction by means of the nebulizer makes 2.5 milligrams, but if necessary can be increased to five milligrams. Inhalations can be carried out to four times a day. In the conditions of a hospital, at the expressed obstruction of airways, the dose for adult patients can be increased up to 40 mg/days.
Clinical performance of application of Ventolin for children is younger than eighteen months by introduction via the nebulizer it was not investigated.

Ventolin Evokhaler. It is intended for application for children aged is more senior than two years and at adults. Patients, it is heavy to them to coordinate dispersion of an inhaler and a breath, need to apply a spacer. The Bebikhaler device is developed for children of younger age.
Adults. Stopping of an attack of a bronchospasm: hundred-two hundred mkg (one-two inhalations).
Prevention of attacks of a bronchospasm which are connected with physical activity or influence of allergen: two hundred mkg (two inhalations) in ten-fifteen minutes prior to action of a provocative factor. Long maintenance therapy: to two hundred mkg (two inhalations) to four times a day.
Children. Stopping of an attack of a bronchospasm: hundred-two hundred mkg (one-two inhalations). Prevention of attacks of a bronchospasm which are connected with physical activity or influence of allergen: hundred-two hundred mkg (one-two inhalations) in ten-fifteen minutes prior to action of a provocative factor. Long maintenance therapy: to two hundred mkg (two inhalations) to four times a day.


Side effects:
reactions of hypersensitivity Are possible: a Quincke's disease, a bronchospasm, a small tortoiseshell, hypotension up to collapse. At use of medicine the lowering of the level of potassium in blood plasma is possible. Also there can be a headache, a tremor, hyperexcitability and hyperactivity. From a cardiovascular system often there is tachycardia, sometimes there is a violation of a warm rhythm: supraventricular tachycardia, premature ventricular contraction, fibrillation of auricles. Ventolin can cause peripheral vasodilation. At Ventolin's application there can be a paradoxical bronchospasm, to considerable strengthening of an asthma after inhalation. In such cases medicine is cancelled, to the patient select alternative methods of treatment. At Ventolin's inhalation the irritation of a mucous membrane of an oral cavity and throat was sometimes observed. Drug can cause muscular spasms.


Contraindication :
Hypersensitivity to any component of medicine. Use of medicine for children up to one and a half years is contraindicated. With care apply at patients with chronic heart failure, arterial hypertension, a thyrotoxicosis, tachyarrhythmias, a pheochromocytoma and also at pregnancy and in the lactation period.


Pregnancy:
At pregnancy medicine is appointed only when the advantage for mother exceeds any potential risk for a fruit. Strictly controlled clinical trials on studying teratogenecity of Ventolin were not conducted. There are data about the birth of children with a polydactylia at those mothers who during pregnancy applied Ventolin, however to accurate interrelation between developing of pathology and administration of medicament is not established. It is possible to use medicament at pregnancy as the risk of a placentary anoxemia for a fruit against the background of uncontrollable bronchial asthma at mother much more exceeds potential risk from administration of drug. However it is necessary to apply Ventolin with care as his reception can cause a hyperglycemia and tachycardia in mother and a fruit and also weakness of patrimonial activity, lowering of arterial pressure and a fluid lungs.


Interaction with other medicines:
Cannot be applied at the same time Ventolin and non-selective beta-blockers (propranolol). In a thyrotoxicosis strengthens tachycardia. Also strengthens effect of medicines which stimulate central nervous system. Increases a likelihood of developing arrhythmia against the background of intake of cardiac glycosides. Ventolin is not contraindicated to patients who accept MAO inhibitors. Theophylline and other xanthines at reception together with Ventolinum increase the probability of emergence of tachyarrhythmias. At reception together with means for inhalation anesthesia and a levodopa there can be ventricular arrhythmias. Intraocular pressure at joint reception of Ventolin with anticholinergics can increase. Glucocorticosteroids and diuretics can strengthen the hypopotassemia caused by Ventolin's application.


Overdose:
At Ventolin's overdose observe the following symptoms: lowering of arterial pressure, tachycardia, tachyarrhythmia, vomiting, muscular tremor, excitement. Seldom — spasms, hallucinations. In blood — a hypopotassemia, lactoacidosis, a hypophosphatemia, a leukocytosis. There can be a respiratory Alkalosis. Symptomatic treatment, medicines from group of cardioselective beta blockers are appointed.


Packaging:
Ventolin Evokhaler — aerosol for inhalations dosed, 100 mkg in one dose, a cylinder of 200 doses. Ventolin of Nebula. Solution for inhalations of a nebula 2.5 milliliter, No. 10. Solution for inhalations of a nebula 2.5 milliliter, No. 40.


Storage conditions:
to Store at a temperature below 30 degrees Celsius. To avoid influence of direct sunshine. Not to freeze. An expiration date — two years. Not to use after expiry date. Ventolin of Nebula to store in original packing at a temperature below 30 degrees Celsius. After opening of aluminum foil to store nebula no more than three months in the place protected from light at a temperature no more than 30 degrees Celsius. Unused solution of Ventolin which remained in the nebulizer cannot be stored, it should be poured out. An expiration date — three years. Not to use medicine after the expiry date specified on packing.


Synonyms:
Salbutamol, Aloprol, Asmadil, Astakhalin, Aerolin, Asmatolum, Albuterolum, Astalin, Ventodisk, Bronkhovaleas, Volmaks, Salamol, Salbutan, Salben, Salbuvent, Sultanolum, Ventilanum, Proventil.


Ingredients:
Ventolin Evokhaler aerosol for inhalations dosed contains 100 mkg of salbutamol in one dose. Other ingredients: HFA 134a gas spray.

Ventolin Nebula solution for inhalations of 2.5 ml contains 2.5 mg of salbutamol. Excipients: sodium chloride, water the purified, sulphuric acid divorced.


In addition:
At treatment of bronchial asthma Ventolin should not be the only or main component of therapy. Increase in need for application β2-адреномиметиков short action for control of symptoms of bronchial asthma demonstrates progressing of a disease. Such state poses a threat for the patient's life therefore the treatment plan has to be revised; the issue of increase in a dose of glucocorticosteroids is resolved. At such patients the control of the maximum expiratory rate is daily carried out. Only the doctor as reception of high doses of medicine can lead to adverse effects can resolve an issue of increase in a dose of Ventolin.

Patsiyentov needs to teach to use correctly aerosol for inhalations or the nebulizer, the efficiency of treatment depends on it. Not to allow hit of aerosol or solution for inhalations in eyes. At use of the nebulizer the synchronization of inhalation with a breath therefore Ventolin Nebula it is preferable to appointment to children and patients of advanced age is not required.

Description of goods is certified by the producer Glakso .

Editorial group Date of creation: 29.03.2023 Date of updating: 05.04.2023 Novgorodsk Yul_ya Boris_vn Author Oleksander V_ktorovich Sevryukov Reviewer

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Frequently asked questions

How much is Ventolin Evokhaler aer. for ing. doser. 100mkg/dose 200 doses?

Prices on Ventolin Evokhaler aer. for ing. doser. 100mkg/dose 200 doses begin from 93.46 UAH for packing. whether

Can give this medicine to children?

Since 4 years. It is necessary to consult with your attending physician more in details.

What storage conditions at aerosol Ventolin (Glakso)?

It agrees with the instruction storage temperature Ventolin (Glakso) makes from 5 °C to 30 °C. To store out of children's reach.

What analogs at aerosol Ventolinum No. 1?

Full analogs Evokhaler Ventolin aer. for ing. doser. 100mkg/dose 200 doses are:

• Salbutamol aer. for ing. doser. 100mkg/dose ball. 200 doses
• Salbutamol-Inteli ing. under davl. susp. 100mkg/dose ball. 10 ml, 200 doses
• Salbutamol-Neo ing. under davl. 100mkg/dose Comte. 12ml/200doz

What country of origin at Ventolin (Glakso)?

Country the producer at Ventolin (Glakso) - France.

Structure

Active ingredient : salbutamol;

1 dose contains salbutamol 100 mkg (in the form of sulfate salbutamol);

Excipient: HFA 134a propellant.

Dosage form

Aerosol for inhalations dosed.

Main physical and chemical properties: white or almost white suspension.

Pharmacotherapeutic group

Means for treatment of obstructive diseases of airways. Adrenergic medicines for inhalation use. Selection agonists of beta2-adrenoceptors. Salbutamol. ATX R03A C02 code.

Pharmacological properties

Pharmacodynamics

Salbutamol is selection agonist of beta2-adrenoceptors. In therapeutic doses affects beta2-adrenoceptors of smooth muscles of bronchial tubes, providing fast (within 5 minutes) and short-term (4-6 hours) a bronkhodilatation at patients with reversible obstruction of airways.

Pharmacokinetics

After inhalation application from 10 to 20% of the entered dose reaches the lower airways. The rest remains in the inhalation device or in a nasopharynx from where it is swallowed. Part of the dose which reached airways is absorbed in tissue of lungs and gets to a blood-groove, but is not metabolized in lungs.

medicine is metabolized by

After hit in a system blood-groove in a liver, emitted mainly with kidneys in not changed state and in the form of a fenolsulfatny metabolite.

medicine Dose which got from a nasopharynx into digestive system is soaked up by

from digestive tract, there passes the first stage of metabolism in a liver before fenolsulfatny connection, then is allocated with kidneys. The most part of medicine is brought out of an organism within 72 hours. Linking with proteins of blood plasma makes 10%.

Indication

Short (from 4 to 6 hours) bronchiectasia with quick start (approximately within 5 minutes) at obstruction of airways.

Stopping of attacks of suffocation at the diseases which are followed by obstruction of airways, such as bronchial asthma.

Prevention of the attacks of a bronchospasm connected with effect of allergen or caused by physical activity.

In complex therapy of patients with bronchial asthma.

Contraindication

Hypersensitivity in the anamnesis to medicine components. Not to use for suspension of uncomplicated premature births or threat of an abortion of dosage forms of salbutamol which are not intended for intravenous administration.

Interaction with other medicines and other types of interactions.

Salbutamol cannot be applied with non-selective blockers of beta adrenoceptors (for example, with propranolol).

Simultaneous use of salbutamol with MAO inhibitors is not contraindicated to

.

Feature of application.

For optimum hit of medicine in lungs of the patient should be checked to his technician of performing inhalation of medicine. Patsiyentov it is necessary to warn about an opportunity to test other taste in comparison with that when using the previous inhaler.

Increase in need for use of bronchodilators, especially short-range inhalation beta2-agonists, for control of symptoms of bronchial asthma demonstrates exacerbation of a disease. In these cases it is necessary to revise the treatment plan and to resolve an issue of purpose of high doses of inhalation corticosteroids or oral corticosteroids.

Sudden and progressing deterioration in bronchial asthma is vitally dangerous state demanding the beginning or increase in application of corticosteroids. The patients belonging to risk group are recommended to carry out control of the maximum expiratory rate daily.

Bronkhodilatatsionny medicines should not be the only or main medicines in treatment of patients with heavy or unstable bronchial asthma. The condition of such patients needs to be controlled regularly, including carrying out pulmonary tests as heavy asthma is vitally dangerous disease and for treatment of such patients it is necessary to resolve an issue of purpose of most recommended doses of inhalation and oral glucocorticosteroids.

If action of a usual dose of Evokhaler Ventolinum becomes less effective or duration of its action (less than 3 hours) decreases, the patient should see a doctor. Increase in a dose or frequency of use of medicine is made only by the doctor.

Heavy exacerbation of asthma should treat in the usual mode.

Sympathomimetics, including salbutamol, influence a cardiovascular system. According to postregistration application and to the published data, there are certificates on exceptional cases of developing of the ischemia of a myocardium associated with use of salbutamol. To the patients having heart troubles (for example coronary heart disease, arrhythmia or heavy heart failure) are also treated by salbutamol, in case of the developing at them of a stethalgia or other symptoms demonstrating exacerbation of a cardiac disease it is necessary to ask for medical care. It is necessary to pay attention to assessment of such symptoms as short wind and a stethalgia which can be a consequence of both a heart trouble, and diseases of a respiratory system.

With care needs to appoint salbutamol a sick thyrotoxicosis.

Result of treatment with beta2-agonists; mainly, it is observed at application of parenteral forms or the nebulizer. Special attention is paid to patients with sharp heavy asthma as the hypopotassemia can be exponentiated by the accompanying application of derivatives of xanthines, steroids, diuretics and a hypoxia. In this situation it is recommended to check potassium level in blood serum.

Salbutamol with care is applied to treatment of the patients receiving high doses of other sympathomimetics. As well as can lead other agonists of beta adrenoceptors, salbutamol to reversible metabolic changes, for example to increase in level of sugar of blood. Compensation of such changes at patients with diabetes is not always possible therefore there are separate messages about development of ketoacidosis in such patients. Simultaneous application of corticosteroids can aggravate this state.

As well as at use of other inhalation medicines the paradoxical bronchospasm with immediate strengthening of an asthma after use of medicine can arise. In this case it is necessary to appoint at once alternative forms of medicine or other high-speed inhalation bronchodilators. Salbutamol it is necessary to cancel, carry out immediately the assessment of a condition of the patient and to appoint other high-speed bronchodilator on a constant basis.

Use during pregnancy and feeding by a breast

according to researches on animals salbutamol has reproductive toxicity. Safety of application of pregnant women is not established. Controlled clinical trials of use of salbutamol to pregnant women were not conducted. There were single messages about various congenital defects at pre-natal development, including a sky crevice, defects of extremities and warm violations. Some women during pregnancy accepted many other medicines. Evokhaler Ventolin it is possible to accept during pregnancy only if necessary.

Salbutamol probably gets into breast milk therefore it is necessary to appoint it nursing with care. Whether renders availability of salbutamol in breast milk the adverse effect on the newborn/baby is unknown therefore its application nursing has to be limited to cases when the advantage of its application for the woman prevails possible risk for the child.

Ability to influence speed of response at control of motor transport or other mechanisms.

is not present

Data on influence. At emergence of side reactions from nervous system (tremor), control of motor transport or work with other mechanisms need to be limited.

Route of administration and doses

Ventolin Evokhaler – the aerosol intended only for inhalation application through a mouth. Patients, it is heavy to them to synchronize breath using an inhaler, are recommended to use in addition a spacer – the device for simplification of inhalation of inhalation medicines.

Adult (including elderly patients)

For knocking over of aggravation of symptoms of asthma, including a sharp bronchospasm, can use 1 inhalation (100 mkg) as the minimum starting dose. If necessary it is possible to increase a dose to 200 mkg (2 inhalations).

Preventively in 10–15 minutes prior to physical activity or the expected contact with allergens are applied by 200 mkg (2 inhalations).

recommends to apply

At long maintenance therapy 200 mkg (2 inhalations) 4 times a day. The general daily dose of salbutamol should not exceed 800 mkg (8 inhalations).

to Children 12 years are more senior than

apply doses as to adults.

Children from 4 to 12 years

For knocking over of a sharp bronchospasm use 1 inhalation (100 mkg). If necessary it is possible to increase a dose to 200 mkg (2 inhalations).

Preventively in 10–15 minutes prior to physical activity or the expected contact with allergens are applied by 100 mkg (1 inhalation), if necessary it is possible to increase a dose to 200 mkg (2 inhalations).

recommends to apply

At long maintenance therapy 200 mkg (2 inhalations) 4 times a day. The general daily dose of salbutamol should not exceed 800 mkg (8 inhalations).

Increased need for beta2-agonists can demonstrate deterioration in asthma. In these conditions it is necessary to see the mode of treatment of the patient and to consider need of purpose of glucocorticosteroid therapy.

Operation manual of an inhaler

Check of an inhaler.

Before the first use of an inhaler or after a break in use of 5 days and more remove a mouthpiece cap, slightly pressing it from sides, well stir up an inhaler and make two squirts in air to be convinced of its adequate work.

Use by an inhaler

1. Remove a mouthpiece cap, slightly pressing it on each side.

2. Make sure that in and outside of an inhaler, including a mouthpiece, there are no foreign objects.

3. Carefully stir up an inhaler to remove any foreign subject from an inhaler and evenly to mix device contents.

4. Take an inhaler in a hand vertically between big and other fingers, and the thumb has to be on the inhaler body below a mouthpiece.

5. Make the deepest exhalation, then take a mouthpiece in a mouth between teeth and capture it lips, without having a snack.

6. Making a breath through a mouth, press an inhaler top to execute spraying of salbutamol, at the same time continue to inhale slowly and deeply. One pressing a top of an inhaler corresponds to one dose.

7. Hold the breath, take an inhaler from a mouth and remove a finger from an inhaler top. Continue to hold the breath so much, as much as possible.

8. If it is necessary to execute further dispersions, wait about 30 seconds, holding an inhaler vertically. Then perform the operations described in Paragraphs 3-7.

9. Press a mouthpiece cap into place pressing in the necessary direction before click.

it is IMPORTANT

:

Perform the operations described in Paragraphs 5, 6 and 7 without hurrying. Before the dispersion it is necessary to inhale as it is possible more slowly. The first several times it is necessary to be trained in front of the mirror. If near a top of an inhaler or on each side a mouth there is a cloud, it is necessary to start the procedure over again from Paragraph 2.

If the doctor gave to

other instructions for use of an inhaler, follow them and also address for council at emergence of any difficulties.

Children. Small children can need the help; there can be a need in order that inhalations by him were carried out by adults. Ask the child to exhale and spray right after he begins a breath. It is recommended to master the equipment together. Children are more senior or the weakened adults can hold an inhaler with both hands. It is necessary to put both forefingers on an inhaler top, and both thumbs – are one basis lower than a mouthpiece.

Cleaning

Inhaler should be cleaned at least 1 time a week.

1. Take a metal cylinder from a plastic case of an inhaler and remove a mouthpiece cap.

2. Wash a plastic case and a cap of a mouthpiece with warm water.

3. Dry up them outside and inside.

4. Place a metal cylinder and a cap of a mouthpiece into place.

DO NOT PUT the METAL CYLINDER IN WATER.

Children.

Drug is intended to

for treatment of children for 4 years.

Overdose

Most common symptoms of overdose of salbutamol are tranzitorny changes, the tachycardias pharmacological induced by beta-agonists, for example, a tremor, hyperactivity and metabolic violations, including a hypopotassemia (see the sections "Features of Application" and "Side reactions").

as a result of overdose of salbutamol the hypopotassemia therefore it is necessary to check potassium level in blood serum can arise. At application of high therapeutic doses or overdose of short-range beta2-agonists it was reported about lactoacidosis cases therefore it is necessary to check lactate level in blood serum and, respectively, to control a metabolic acidosis, especially in case of the steady or amplifying accelerated breath, despite simplification, such as stidor breath.

Side reactions

Side reactions given below are classified by

by bodies and systems and also by the frequency of their emergence: very often (1/10), it is frequent (1/100 and 1/10), infrequently (1/1000 and 1/100)), is rare (³ 1/10000 and 1/1000), is very rare (1/10000), including isolated cases, frequency is unknown. Generally, very frequent and frequent side effects are determined by data of clinical trials whereas rare, very rare and with an unknown frequency – according to spontaneous messages.

from the immune system

It is very rare: reactions of hypersensitivity, including a Quincke's disease, a small tortoiseshell, a bronchospasm, arterial hypotension and collapse.

from a metabolism, metabolism

it is rare: hypopotassemia. Potentially use of beta2-agonists can cause the expressed hypopotassemia.

Neurologic frustration

it is frequent: tremor, headaches.

It is very rare: hyperactivity.

Cardial violations

Often tachycardia.

Infrequently: the strengthened heartbeat.

It is very rare: violation of a warm rhythm, including fibrillation of auricles, supraventricular takhikar