Enroksil synthetic antibacterial chemotherapeutic broad-spectrum agent from group of ftorkhinolon of the II generation.
Enrofloxacin which is a part of medicine possesses to wide ranges of antibacterial and antimikoplazmenny action. It is active concerning gram-positive and gram-negative microorganisms, such as E. coli, Salmonella spp., Pasteurella haemolytica, Pasteurella multocida, Staphylococcus aureus, Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, Campylobacter spp., Corynebacterium pyogenes, Proteus spp., Mycoplasma spp., Brucella canis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium perfingens, etc.
Mechanism of effect of enrofloxacin consists in inhibition of activity of the enzyme of a giraza providing replication of a spiral of DNA in a kernel of a bacterial cage that leads to violation of synthesis of protein and death of a microorganism.
Indication to application: at infections of respiratory organs, digestive tract, an urinogenital system, at a kolibakterioza, a septitsemiya, salmonellosis, atrophic rhinitis, a streptokokkoza, bacterial and enzootichesky pneumonia, MMA syndrome, and other diseases which causative agents are sensitive to enrofloxacin. Species of an animal Dogs Category of veterinary medicine Antibiotics Area of application of veterinary medicine Other types of diseases
Diseases of respiratory organs
Gastrointestinal diseases
Diseases of an urinogenital system Medicines Chemotherapeutic medicines Form Solutions for injections
Enrofloxacin which is a part of medicine possesses to wide ranges of antibacterial and antimikoplazmenny action. It is active concerning gram-positive and gram-negative microorganisms, such as E. coli, Salmonella spp., Pasteurella haemolytica, Pasteurella multocida, Staphylococcus aureus, Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, Campylobacter spp., Corynebacterium pyogenes, Proteus spp., Mycoplasma spp., Brucella canis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium perfingens, etc.
Mechanism of effect of enrofloxacin consists in inhibition of activity of the enzyme of a giraza providing replication of a spiral of DNA in a kernel of a bacterial cage that leads to violation of synthesis of protein and death of a microorganism.
Indication to application: at infections of respiratory organs, digestive tract, an urinogenital system, at a kolibakterioza, a septitsemiya, salmonellosis, atrophic rhinitis, a streptokokkoza, bacterial and enzootichesky pneumonia, MMA syndrome, and other diseases which causative agents are sensitive to enrofloxacin.
Before use of medicine consult with the veterinarian and study the INSTRUCTION given below!!!
I. General information.
1. Trade name of medicine: Enroksil of 5% solution for injections (Enroxil 5% of solutio pro injectionibus).
International non-proprietary name: enrofloxacin.
2. Dosage form: solution for injections.
Enroksil of 5% solution for injections in quality, active ingredient contains enrofloxacin of 50 mg in 1 ml, and as excipients: butanol, potassium hydroxide and water for injections.
3. On appearance medicine represents transparent solution of yellowish color.
medicine Expiration date at observance of storage conditions – 5 years from the date of production, after the first opening – 28 days.
forbidden to use medicine after an expiration date.
4. Release Enroksil 5% solution for injections packaged on 100 ml in bottles from dark glass of the corresponding capacity. Each bottle is placed in a cardboard box and supplied with the instruction for application.
5. Store medicine in the closed packing of the producer in the place protected from direct sunshine, separately from food and forages, at a temperature from 5 0 With to 25 0 S.
6. It is necessary to store medicine in the places inaccessible for children.
7. Unused medicine is utilized according to requirements of the legislation.
8. It is released without prescription of the veterinarian.
International non-proprietary name: enrofloxacin.
2. Dosage form: solution for injections.
Enroksil of 5% solution for injections in quality, active ingredient contains enrofloxacin of 50 mg in 1 ml, and as excipients: butanol, potassium hydroxide and water for injections.
3. On appearance medicine represents transparent solution of yellowish color.
medicine Expiration date at observance of storage conditions – 5 years from the date of production, after the first opening – 28 days.
forbidden to use medicine after an expiration date.
4. Release Enroksil 5% solution for injections packaged on 100 ml in bottles from dark glass of the corresponding capacity. Each bottle is placed in a cardboard box and supplied with the instruction for application.
5. Store medicine in the closed packing of the producer in the place protected from direct sunshine, separately from food and forages, at a temperature from 5 0 With to 25 0 S.
6. It is necessary to store medicine in the places inaccessible for children.
7. Unused medicine is utilized according to requirements of the legislation.
8. It is released without prescription of the veterinarian.
II. Pharmacological properties.
9. Enroksil of 5% solution for injections treats antibacterial medicines of group of ftorkhinolon.
10. The enrofloxacin which is a part of medicine possesses to wide ranges of antibacterial and antimikoplazmenny action. It is active concerning gram-positive and gram-negative microorganisms, such as E. coli, Salmonella spp., Pasteurella haemolytica, Pasteurella multocida, Staphylococcus aureus, Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, Campylobacter spp., Corynebacterium pyogenes, Proteus spp., Mycoplasma spp., Brucella canis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium perfingens, etc.
Mechanism of effect of enrofloxacin consists in inhibition of activity of the enzyme of a giraza providing replication of a spiral of DNA in a kernel of a bacterial cage that leads to violation of synthesis of protein and death of a microorganism.
After parenteral introduction of medicine enrofloxacin is well soaked up from the place of an injection and gets into all bodies and body tissues. Its maximum concentration in blood is reached in 1.0-1.5 hours and keeps at the therapeutic level for 24 hours. Enrofloxacin from an organism of animals generally in not changed view with urine and bile is emitted.
Enroksil solution for injections on extent of impact on an organism according to GOST 12.1.007-76 belongs of 5% to the 3rd hazard class (substances moderately dangerous).
10. The enrofloxacin which is a part of medicine possesses to wide ranges of antibacterial and antimikoplazmenny action. It is active concerning gram-positive and gram-negative microorganisms, such as E. coli, Salmonella spp., Pasteurella haemolytica, Pasteurella multocida, Staphylococcus aureus, Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Pseudomonas aeruginosa, Bordetella bronchiseptica, Campylobacter spp., Corynebacterium pyogenes, Proteus spp., Mycoplasma spp., Brucella canis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium perfingens, etc.
Mechanism of effect of enrofloxacin consists in inhibition of activity of the enzyme of a giraza providing replication of a spiral of DNA in a kernel of a bacterial cage that leads to violation of synthesis of protein and death of a microorganism.
After parenteral introduction of medicine enrofloxacin is well soaked up from the place of an injection and gets into all bodies and body tissues. Its maximum concentration in blood is reached in 1.0-1.5 hours and keeps at the therapeutic level for 24 hours. Enrofloxacin from an organism of animals generally in not changed view with urine and bile is emitted.
Enroksil solution for injections on extent of impact on an organism according to GOST 12.1.007-76 belongs of 5% to the 3rd hazard class (substances moderately dangerous).
III. Application order.
11. Enroksil 5% appoint solution for injections to a farm animal and dogs at infections of respiratory organs, digestive tract, an urinogenital system, at a kolibakterioza, a septitsemiya, salmonellosis, atrophic rhinitis, a streptokokkoza, bacterial and enzootichesky pneumonia, MMA syndrome, and other diseases which causative agents are sensitive to enrofloxacin.
Medicine has to be applied according to official and local rules of use of antibacterial medicines.
Before use of medicine, whenever possible, has to be executed the test for sensitivity of the activator to enrofloxacin.
Medicines containing ftorkhinolona belong to reserve antibacterial medicines and have to be applied when other antibacterial medicines are not effective.
12. A contraindication to Enroksils application of 5% of solution for injections is the increased individual sensitivity of an animal to ftorkhinolona. Use of medicine is forbidden to animals with the expressed violations of development of cartilaginous tissue, at the damages of nervous system which are followed by spasms at severe damages of a liver and kidneys and also at allocation at a sick animal of the microorganisms resistant to ftorkhinolona.
13. During the work with Enroksil of 5% as solution for injections it is necessary to follow the general rules of personal hygiene and safety measures provided during the work with medicines. In operating time it is forbidden to smoke, drink and eat food. Upon termination of work it is necessary to wash up carefully with soap a face and hands.
14. Studying safety of medicine at application by the lactating and pregnant animal was not carried out. Use of medicine to these groups of animals after assessment of a ratio of advantage and risk by the veterinarian is possible. Enroksils application ® 5% of solution for injections is forbidden to puppies 12 months (to puppies of large breeds – 18 months are younger) as perhaps negative impact on development of cartilaginous tissue during growth of an animal are younger.
15. Enroksil 5% apply solution to injections to calfs, sheep and goats hypodermically, and to pigs, subpigs and sows intramuscularly once a day within three-five days, in a dose of 1 ml on 20 kg of mass of an animal (2.5 mg of enrofloxacin on 1 kg of mass of an animal). Enroksil 5% solution for injections appoint by
At salmonellosis and infections of respiratory organs within five days in a dose 1 ml to 10 kg of mass of an animal once a day (5.0 mg of enrofloxacin on 1 kg of mass of an animal). to Dogs Enroksil 5% appoint solution for injections by
hypodermically once a day in a dose 1 ml on 10 kg of mass of an animal (5 mg of enrofloxacin on 1 kg of mass of an animal) within five days, if necessary duration of treatment can be increased up to ten days.
In view of possible painful reaction Enroksil of 5% solution for injections should be entered in number of no more than 5 ml into one place a large animal and no more than 2.5 ml — a small animal.
16. By-effects and complications at animals at use of medicine according to the present instruction, as a rule, are not observed. In case of allergic reactions use of medicine is stopped and appoint to an animal antihistaminic and symptomatic medicines. In some cases perhaps short-term dysfunction of digestive tract. In the place of an injection the emergence of irritation, disappearing spontaneously is possible.
17. Symptoms of overdose of medicine at animals are not revealed. At calfs degenerative changes of articulate cartilages at oral use of enrofloxacin in a dose of 30 mg/kg within 14 days were observed.
18. Simultaneous application of Enroksil of 5% of solution for injections with chloramphenicol, macroleads, tetracyclines, theophylline and nonsteroid resolvents is not allowed.
19. Features of effect of medicine at its first application and cancellation it is not established.
20. Violation of the scheme of use of medicine can lead to emergence of resistance of microorganisms to ftorkhinolona and decrease in efficiency of their application owing to cross resistance. It is necessary to avoid the admission of the next dose of medicine. In case of the admission of one dose the use of medicine is resumed in the same dosage and according to the same scheme.
21. Slaughter of animals on meat is allowed not earlier than in 14 days after the last use of medicine. Meat of animals, forcedly killed before the expiration of the specified term, can be used for feeding of fur animals.
Packing : bottle, 100 ml
Producer : KRKA, Krka, d. d., Slovenia
Medicine has to be applied according to official and local rules of use of antibacterial medicines.
Before use of medicine, whenever possible, has to be executed the test for sensitivity of the activator to enrofloxacin.
Medicines containing ftorkhinolona belong to reserve antibacterial medicines and have to be applied when other antibacterial medicines are not effective.
12. A contraindication to Enroksils application of 5% of solution for injections is the increased individual sensitivity of an animal to ftorkhinolona. Use of medicine is forbidden to animals with the expressed violations of development of cartilaginous tissue, at the damages of nervous system which are followed by spasms at severe damages of a liver and kidneys and also at allocation at a sick animal of the microorganisms resistant to ftorkhinolona.
13. During the work with Enroksil of 5% as solution for injections it is necessary to follow the general rules of personal hygiene and safety measures provided during the work with medicines. In operating time it is forbidden to smoke, drink and eat food. Upon termination of work it is necessary to wash up carefully with soap a face and hands.
14. Studying safety of medicine at application by the lactating and pregnant animal was not carried out. Use of medicine to these groups of animals after assessment of a ratio of advantage and risk by the veterinarian is possible. Enroksils application ® 5% of solution for injections is forbidden to puppies 12 months (to puppies of large breeds – 18 months are younger) as perhaps negative impact on development of cartilaginous tissue during growth of an animal are younger.
15. Enroksil 5% apply solution to injections to calfs, sheep and goats hypodermically, and to pigs, subpigs and sows intramuscularly once a day within three-five days, in a dose of 1 ml on 20 kg of mass of an animal (2.5 mg of enrofloxacin on 1 kg of mass of an animal). Enroksil 5% solution for injections appoint by
At salmonellosis and infections of respiratory organs within five days in a dose 1 ml to 10 kg of mass of an animal once a day (5.0 mg of enrofloxacin on 1 kg of mass of an animal). to Dogs Enroksil 5% appoint solution for injections by
hypodermically once a day in a dose 1 ml on 10 kg of mass of an animal (5 mg of enrofloxacin on 1 kg of mass of an animal) within five days, if necessary duration of treatment can be increased up to ten days.
In view of possible painful reaction Enroksil of 5% solution for injections should be entered in number of no more than 5 ml into one place a large animal and no more than 2.5 ml — a small animal.
16. By-effects and complications at animals at use of medicine according to the present instruction, as a rule, are not observed. In case of allergic reactions use of medicine is stopped and appoint to an animal antihistaminic and symptomatic medicines. In some cases perhaps short-term dysfunction of digestive tract. In the place of an injection the emergence of irritation, disappearing spontaneously is possible.
17. Symptoms of overdose of medicine at animals are not revealed. At calfs degenerative changes of articulate cartilages at oral use of enrofloxacin in a dose of 30 mg/kg within 14 days were observed.
18. Simultaneous application of Enroksil of 5% of solution for injections with chloramphenicol, macroleads, tetracyclines, theophylline and nonsteroid resolvents is not allowed.
19. Features of effect of medicine at its first application and cancellation it is not established.
20. Violation of the scheme of use of medicine can lead to emergence of resistance of microorganisms to ftorkhinolona and decrease in efficiency of their application owing to cross resistance. It is necessary to avoid the admission of the next dose of medicine. In case of the admission of one dose the use of medicine is resumed in the same dosage and according to the same scheme.
21. Slaughter of animals on meat is allowed not earlier than in 14 days after the last use of medicine. Meat of animals, forcedly killed before the expiration of the specified term, can be used for feeding of fur animals.
Packing : bottle, 100 ml
Producer : KRKA, Krka, d. d., Slovenia
Diseases of respiratory organs
Gastrointestinal diseases
Diseases of an urinogenital system
| Characteristics | |
| Area of application of veterinary medicine | Other types of diseases of the Disease of respiratory organs of the Gastrointestinal disease of the Disease of an urinogenital system |
| Category of veterinary medicine | Antibiotics |
| Drugs | Chemotherapeutic medicines |
| Release form | Solutions for injections |
| Species of an animal | Dogs |
Enroxil by KRKA of 5% - The antibacterial medicine Enroksil of 5% (solution for injections)
- Product Code: E-ZOO-104776
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