tablets "Enalapril-HL-Zdorovye" are applied in arterial hypertension at patients to whom combination therapy is shown.

Structure

One tablet contains (active ingredients):

• enalapril of a maleate - 10 mg;
• a hydrochlorothiazide - 12.5 mg.

Excipients: lactoses monohydrate, cellulose microcrystalline, sodium of a kroskarmelloz, starch prezhelatinizirovanny, potato starch, magnesium stearate, silicon dioxide colloidal anhydrous, povidone.

Contraindication

• hypersensitivity to enalapril and other inhibitors of angiotensin-converting enzyme (APF), a hydrochlorothiazide and to other derivatives of sulfonamides or to other components of drug;
• existence in the anamnesis of the Quincke's disease connected with the previous treatment by APF inhibitors;
• hereditary or idiopathic Quincke's disease;
• patients with heavy renal failures (the clearance of creatinine less than 30 ml/minute or level of creatinine in blood serum exceeds 265 µmol/l (3 mg / 100 ml));
• renal artery stenosis;
to
• it is contraindicated when carrying out a hemodialysis;
• a clinical state after transplantation of a kidney;
• heavy abnormal liver functions;
• anury, primary hyper aldosteronism;
• hypopotassemia, resistant to treatment, or hyperpotassemia;
• refractory hyponatremia;
• symptomatic hyperuricemia (gout);
• pregnant women or women who are going to become pregnant;
• should not apply enalapril with the medicaments containing aliskiren, to patients with diabetes or with a renal failure (SKF <60 ml/minute / 1.73 m ² ).

Route of administration

Arterial hypertension. To appoint tablets with the fixed combination of enalapril of a maleate and a hydrochlorothiazide to patients at whom arterial blood pressure is insufficiently controlled only by one enalapril.

for initial therapy and it is usually recommended after correction of doses separately of each of components. But at clinical expediency it is possible to pass from monotherapy to the fixed combination at once.

Mode of dosing is set by the doctor individually depending on a condition of the patient and severity of arterial hypertension. Treatment should be begun with low doses of medicament with gradual increase in a dosage. To use medicament inside irrespective of meal. The established daily dose should be accepted in the morning together with a large amount of liquid.

Usually the dose makes one tablet which it is necessary to apply 1 time a day. If necessary the dosage can be raised to two tablets a day which it is necessary to apply 1 time a day.

Pregnant

APF Inhibitors it is contraindicated to the pregnant women and women planning pregnancy to apply

Feature of use

Limited pharmacokinetic data confirm very low concentration in breast milk. Though such concentration are also considered as clinically insignificant, use of medicament is not recommended during feeding by a breast of newborns as there is a hypothetical risk of effects from a cardiovascular system and kidneys and also because of insufficient experience of such use.

Safety and efficiency of use of medicament are not established to children by

.

Drivers

careful and to consider possibility of undesirable reactions from nervous system, including dizziness or drowsiness.

Overdose

Treatment - symptomatic and supporting. Use of medicament should be stopped and to carefully examine the patient. The proposed measures include: provoking of vomiting if the medicament was taken recently and also correction of dehydration, an electrolytic imbalance and arterial hypotension by means of the standard actions.

Enalapril maleate. The main manifestation of overdose is the profound arterial hypotension, arises within 6 hours after administration of medicament and is followed by blockade RAAS and a stupor. The recommended treatment at overdose is introduction of 0.9% of solution of sodium of chloride. Enalapril can be removed from system blood circulation by means of a hemodialysis. In the bradycardia resistant to therapeutic means, therapy by means of a pacemaker is shown.

Hydrochlorthiazidum. Frequent signs and symptoms are manifestations of a hypopotassemia, a hypochloraemia, a hyponatremia and dehydration owing to an excessive diuresis. It is necessary to control constantly important vital signs, concentration of electrolytes and level of creatinine in blood serum.

Side effects

Most frequent side reactions were dizziness and increased fatigue which usually disappeared at a dose decline and seldom demanded medicament withdrawal.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 4 years.