Pharmacological properties

group Vitamins in (b1, b2, b6, pantothenic acid and niacinamide) participate in processes of exchange of carbohydrates, proteins and fats, they are also important for functioning of nervous system. vitamin A is necessary for development of cells of an epithelium and synthesis of a rhodopsin. vitamin D regulates digestion of calcium and promotes an appropriate mineralization of bones and teeth. vitamin C controls absorption of iron and takes part in oxidation-reduction processes in an organism. vitamin E, physiological antioxidant, protects cell membranes from damages and keeps their functionality.

for an organism. They are components of fabrics or activators and components of enzymes and hormones. The calcium and phosphorus which are a part of the medicine Duovit — the main mineral components of a bone tissue and teeth. Calcium ions activate many enzymes, participate in regulation of a tone of a cardiac muscle, transfer of nervous impulses and regulate permeability of cellular membranes. Iron and copper along with vitamins of group B are necessary for an erythrogenesis. Magnesium, manganese, zinc and molybdenum are a part of the majority of the enzymes catalyzing the major biochemical reactions in an organism.

within daily requirement. Quantities which exceed absorption by fabrics are removed with urine, in certain cases — also with a stake.

After oral administration in a small intestine in the presence of fats. Vitamin E absorption rather low (25–85% of a dose). These vitamins collect in large numbers in a liver and therefore they are more toxic, than water-soluble vitamins.

Indication

Duovit, a tablet, coated, are recommended at:

• physical and mental overworks (when training, at work or houses);
• occupations active sports and active holiday;
• insufficient consumption of food (people of advanced age, smokers and patients with alcoholism);
• irregular and monotonous food (generally instant food, dry food);
• observance of a diet for weight loss (at degrowth of a body, diabetes, etc.);
• during pregnancy and feeding by a breast;
• in the period of seasonal deficiency of fruit and vegetables in a diet;
• at considerable loss of mineral substances (owing to vomiting, diarrhea, plentiful menstrual blood loss, the increased sweating).

Use

to Adults and children is aged more senior than 10 years recommend to accept on 1 tablet duovit red color with vitamins and on 1 tablet duovit blue color with minerals of 1 times a day. a pill is taken after a breakfast, whole without chewing, washing down with liquid. duration of treatment is defined by the doctor individually.

Contraindication

Hypersensitivity to medicine components, a hypervitaminosis and, e and d, a renal failure. the nephrolithiasis, gout, a hyperuricemia, an erythremia, a hyperglobulia, thrombophlebitis, a thrombembolia, intolerance of fructose, a glucose galactose sprue, violation of exchange of iron or copper, a hypercalcemia, a hypercalcuria, a thyrotoxicosis, chronic gromerulonefrit, chronic heart failure, a sarcoidosis in the anamnesis, a peptic ulcer of a stomach and duodenum (in connection with possible increase in acidity of gastric juice), active forms of tuberculosis. children's age up to 10 years.

Side effects which can arise at use of medicine duovit

, are classified in the following groups according to emergence frequency: very often (1/10); often (1/100, 1/10); infrequently (1/1000, 1/100); seldom (1/10,000, 1/1000); very seldom (10,000); frequency is unknown (it is impossible to determine by the available data).

side effects are provided to

In each group as reduction of gravity.

If to take a pill of Duovit to destination, then they do not cause side effects.

from the immune system: at persons with hypersensitivity allergic reactions, including an acute anaphylaxis, a Quincke's disease, a bronchospasm are possible.

from metabolism and digestion: hypercalcemia.

from nervous system: headache, dizziness, drowsiness.

from an organ of sight: disorder of vision.

from a GIT: dispeptic violations, nausea, vomiting, stomach ache, eructation, lock, diarrhea, increase in secretion of gastric juice.

from skin and hypodermic cellulose: skin rashes, urticaria, itch, erubescence.

from kidneys and a bladder: urine decolouration, hypercalcuria.

General violations: a hyperthermia, hyperexcitability, the increased sweating.

At long application in high doses the following side effects arise:

from metabolism and digestion: a hyperuricemia, decrease in tolerance to glucose, a hyperglycemia.

from nervous system: paresthesias.

from a cardiovascular system: arrhythmias.

from a GIT: irritation of a mucous membrane of a GIT.

from skin and hypodermic cellulose: dryness and cracks on palms and stupnyakh, a hair loss, seborrheal rashes.

from kidneys and a bladder: renal failure.

Laboratory indicators: tranzitorny increase in activity of AsAT, LDG, SF.

Special instructions

Duovit after a meal, otherwise there can be unpleasant feelings in a stomach.

Patients with diabetes can apply Duovit, but they should consider that the daily dose contains 1.6 g of sugar. Each tablet, coated, contains 0.8 g of sugar.

With care is appointed at damages of a liver, a round ulcer of a stomach and duodenum in the anamnesis, to patients with sharp nephrite, at a decompensation of warm activity, cholelithiasis, chronic pancreatitis, allergic diseases, an idiosyncrasy, sick diabetes, to patients with new growths.

to the Women accepting Retinolum in high doses (10,000 ME) can plan pregnancy not earlier, than in 6–12 months. It is connected with the fact that throughout this period there is a risk of maldevelopment of a fruit under the influence of the high content of vitamin A in an organism. Coloring of urine in yellow color is possible that it completely harmlessly and is explained by existence in Riboflavinum drug.

Drug is not recommended to appoint along with other polyvitamins as the overdose of the last in an organism is possible.

Special cautions of rather inactive ingredients. Duovit contains lactose, sorbitol, glucose and sucrose. Patients with rare hereditary forms of fructose or galaktozny intolerance, deficiency of Lappa lactases either glyukozo-galaktozny malabsorption, or sakharazo-izomaltazny insufficiency cannot take this drug. E124 and E110 azoic dyes can cause allergic reactions.

during pregnancy and feeding by a breast it is possible to accept vitamins and minerals only on doctor's orders.

Ability to influence speed of response at control of vehicles and work with other mechanisms. There are no messages that medicine affects ability to control of vehicles and work with other mechanisms.

Children. Duovit do not recommend to accept to children aged up to 10 years.

Interaction

do not recommend to use medicament along with tetracyclines and antiacid means as at the same time absorption of minerals and tetracyclines decreases. some antiacid means reduce absorption of minerals. if the concomitant use of such medicines is necessary, then the interval between application of tablets duovit also tetracycline or antiacid means has to make not less than 3 h

Owing to possible developing of a hypervitaminosis And simultaneous application of Duovit with other medicines containing vitamin A or oral retinoids is not recommended.

Should avoid use of vitamin E at use of oral anticoagulants in view of increase in tendency to bleeding.

during therapy by streptocides for prevention of a crystalluria should not accept vitamin C in high doses.

Piridoksin weakens action of a levodopa if the patient accepts only a levodopa.

Riboflavinum reduces absorption and efficiency of antibiotics. It should be taken at least for 3 h to or 3 h after reception of an antibiotic.

At the recommended dispensing no intoxication is supposed

. for a long time, application in high doses can cause a hypervitaminosis and and d though the probability of overdose is minimum. at overdose of vitamin D there are a weakness, anorexia, nausea, vomiting, diarrhea, degrowth of a body, fever, spasms. the overdose of vitamin A can lead to a headache, dizziness, a sleep disorder, nausea, vomiting, drowsiness, a photophobia and spasms. at emergence of the above-stated symptoms it is necessary to stop administration of medicament and to see immediately a doctor. at use of vitamin E in high doses there can be a headache, fatigue, nausea, a diplopia, muscle weakness, an easy creatinuria and gastrointestinal violations.

Storage conditions

In original packing for protection against moisture and light at a temperature not above 25 °C.