Duonefril contains the evidence-based combination of vegetable matters having nefroprotektorny properties.

Duonefril in combination with traditional approaches promotes preservation and improvement of function of kidneys, due to increase in an indicator of glomerular filtration rate and hypoazotemic action in a chronic disease of kidneys against the background of diabetes, a hypertension and other defeats.

Active components

receive Extract of a lespedeza of capitate (Lespedeza capitata) from a plant of family bean, coming from northeast America. Biologically active components of extract are pro-anthocyanidins and flavonoids, in particular lespedezin, a well-known natural component with diuretic and nefroprotektorny properties.

Extract of a lespedeza can be applied in a renal failure, in particular by persons with heart diseases and/or obesity, because of normolipidemichesky, hypoazotemic and diuretic properties. Flavonoids of a lespedeza are characterized by the powerful antioxidant properties implemented in kidney tissues by prevention of development of microinflammation of renal balls.

Silymarinum is flavolignany, receiving from a thistle of spotty Silybum marianum. The thistle and its flavonoids are one of the most widely used nutritsevtik in the United States and Europe with huge evidential base and a wide profile of safety. Due to powerful antioxidant action Silymarinum promotes increase in level of two additional antioxidants, glutathione and superoxide dismutases, including renal fabric.

Silymarinum concentrates in cells of kidneys where it promotes restoration and regeneration by increase in synthesis of protein and nucleic acids. In randomized controlled study it was also established that it is effective at decrease in a proteinuria at patients with type 2 diabetes with a nephropathy. Decrease in a proteinuria was connected with antioxidant and anti-inflammatory effect of Silymarinum. Silymarinum has positive impact on prevention or reduction of weight of nephrotoxicity of Cisplatinum.

by

as an additional source of biologically active agents of plant origin contributing to normalization of a functional condition of kidneys.

Biologically Duonefril active agents promote increase in renal filtration and a diuresis (accelerating removal of nitrogenous slags and can promote reduction of an azotemia), reduce an oxidizing stress and prevent microinflammation due to improvement of antioxidant protection of cells at the different levels.

Route of administration

to Use

adult on 1 capsule three times a day, irrespective of meal, washing down with enough water.

Recommended use course: 3 months, however it has to be defined by the doctor individually with character and features of a functional condition of kidneys. If necessary the course can be repeated.

Before the use should consult with the doctor.

Contraindication

Period of pregnancy and feeding by a breast, individual immunity to components.

not to exceed the recommended quantity for daily consumption.

should not be used as replacement of an adequate diet of food.

1 capsule contains

: active ingredients:

• extract of a stalk and leaves of a lespedeza of capitate (Lespedeza capitata) – 300 mg (mg),
• Silymarinum (Silymarin) – 50 mg (mg);
• other components: fillers: microcrystalline cellulose, maltodextrin, calcium stearate, silicon dioxide (orisit), calcium a carbonate; capsule cover: gelatin.

Storage conditions

to Store

in original packing in dry, protected from light and the place, inaccessible for children, at a temperature from 4 to 25 °C.