Dermasinum cream is applied at the following indications:

• prevention of infection and treatment of the infected burns, decubituses, ulcers, superficial wounds with weak exudation, grazes;
• prevention of infection at transplantation of skin.

Structure

Active ingredient - silver sulfadiazine (1 g of cream contains silver of Sulfadiazinum 10 mg).

Excipients: cetyl alcohol, the peanut butter hydrogenated polysorbate 60, propylene glycol, methylparaben (methylparahydroxybenzoate) (E 218), propylparaben (propilparagidroksibenzoat) (E 216), the water purified.

Contraindication

• hypersensitivity to silver Sulfadiazinum, streptocides or to any other ingredient of drug;
• hypersensitivity to peanut nut or soy;
• porphyria;
• genetic deficit glyukozo-6-fosfatdegidrogenazy (at use on big surfaces there can be a hemolysis);
• purulent and burn wounds with plentiful exudation it (is inexpedient);
• premature children, newborns and children up to 3 months (in connection with danger of developing of bilirubinovy encephalopathy).

by

for external topical administration.

Corresponding mode of treatment to select

after assessment of the sizes and depth of a wound surface.

cream to apply

After cleaning of a surface of a burn or other wound with a thin layer (2-4 mm) on the damaged surface (or on a sterile gauze napkin which to impose on a wound surface). Cream is applied sterile with spatula or a hand in ​​ to a sterile glove, usually 1 time a day, in hard cases - 2 times a day.

Before each subsequent putting cream a burn surface needs to wash 0.9% with solution of sodium of chloride or solution of an antiseptic agent for removal of residues of cream and wound exudate. It is possible to apply a bandage.

Route of administration and a dose of medicament do not depend on age of the patient. To use medicament to a complete wound healing or till the moment when the surface of a wound is prepared ​​ for the corresponding surgical intervention. In case of medicament use not on doctor's orders it is necessary to address it for consultation if after 7 days of treatment the condition of the patient did not improve or worsened.

Cream does not leave to

spots on clothes and bed linen.

Feature of use

Pregnant

Considering limited experience and risks (streptocides at system use force out bilirubin from places of linking with albumine in blood plasma that can provoke a hyperbilirubinemia and a kernicterus at newborns), medicament should not be used during pregnancy. The women planning pregnancy should appoint Sulfadiazinum of silver with care.

Knows that streptocides increase risk of bilirubinovy encephalopathy at newborns therefore use of cream is contraindicated during feeding by a breast.

Children

Due to danger of developing of a kernicterus cannot apply silver Sulfadiazinum to premature children, newborns and children up to 3 months.

, it is recommended to appoint medicament to patients of this age category after consultation with the doctor.

Drivers

Data on an adverse effect of cream on speed of response at control of motor transport or other mechanisms are absent.

intoxication Symptoms

At overdose of cream the emergence of the side effects connected with system use of all streptocides is possible

. Prolonged use of high doses of Sulfadiazinum of silver can cause increase in level of serumal silver. However these levels are normalized after the treatment termination. The phenomenon of overdose can be followed by neurologic, renal, hepatic, respiratory and hematologic manifestations.

more than 10 kg of Sulfadiazinum of silver a day were observed by

At patients with heavy burns at long-term treatment and use substantial increase of osmolarity of blood serum. Propylene glycol (component of a cream basis of drug) and as the result, improvement of a reabsorption of medicine in considerable burns, influences in general skin can be the cause of it.

Treatment of intoxication

At overdose medicament should be cancelled. Symptomatic treatment. In case of need it is necessary to control function of kidneys and indicators of blood. Sulfadiazinum which was soaked up is easily removed haemo - and peritoneal dialysis.

Side reactions are given by

on frequency: very often (≥ 1/10), it is frequent (≥ 1/100, <1/10), infrequently (≥ 1/1000, <1/100), is rare (≥ 1/10000, <1/1000), is very rare (<1/10000), frequency is unknown (it cannot be calculated on the available data).

from blood: often - a leukopenia, a methemoglobinemia, especially at patients with anomalies of hemoglobin, increase is osmolarities of blood serum. The Tranzitorny leukopenia usually does not demand the termination of therapy or use of other special events. Monitoring of indicators of blood of the patient is recommended.

from skin and hypodermic fabric: often - hypersensitivity reactions, irritation and erubescence, an itching, burning, pain when drawing, rash, contact dermatitis, discoloration of skin on gray under the influence of sunlight (an argiriya - the pigmentation caused by silver adjournment), a photosensitization, skin necrosis; very seldom - Stephens-Johnson's syndrome, a toxic epidermal necrolysis; frequency is unknown (it cannot be calculated on the available data) - a hyperpegmentation, cold and asthma of allergic origin, decolouration of skin, a multiformny erythema.

Storage conditions

to Store

at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.