B other research provided results of complex therapy of 37 patients operated in connection with development of sharp abdominal surgical diseases. To 22 patients local therapy of 0.02% was carried out by antiseptic solution of decamethoxynum. Positive influence on a clinical course of diseases is noted, decrease in frequency is purulent - septic complications, in particular at the patients operated concerning sharp necrotic pancreatitis (Konovalov E.P., 2004).

provided experience of treatment of 91 patients with peritonitis of various genesis using an antiseptic agent Dekasang . The expressed clinical performance in comparison with other antiseptic agents in complex treatment of peritonitis is noted (Nazirov F.N., 2014).

On the basis of the analysis of results of researches it was established that use of solution of a cationic antiseptic agent (including 0.02% of solution of decamethoxynum) for sanitation of an abdominal cavity allows to reduce microbic pollution when carrying out sanitation and also thanks to it decrease the frequency of postoperative complications at surgical peritonitis and quantity of cases of a lethal outcome (Boiko V.V. et al., 2012).

At 102 patients analyzed efficiency Dekasang in treatment of purulent infections of pararectal area. According to the obtained data Dekasang is effective medicine for local therapy of this pathology (Zakharash M.P., 2011).

as effective medicine for prevention of suppuration of postoperative wounds after excision of pararectal or coccygeal epithelial cysts (Klimenko A.N., Iukhimets A.D., 1982).

B one of clinical trials studied efficiency Dekasang in complex therapy of necrosis of soft tissues as a result of which sepsis developed. Sepsis is the heavy generalized infection caused by usually pathogenic bacteriums. It often is the reason of hospitalization and a lethal outcome. The experience got as a result of a research promoted the best understanding patomekhanizm of this state, development of the therapy directed to improvement of the general condition of patients and also which is surely including topical administration antibacterial and antiseptics in a suppurative focus. The research included 192 patients (women — 103, men — 89). According to classification of septic states (Chicago, 1991) patients were divided into 3 groups: the 1st group — with a local form of an infection, the 2nd group — with a syndrome of the system inflammatory answer (SSVO, English abbreviation of SIRS) which lasts up to 72 h, the 3rd group — with various forms of sepsis at which SSVO lasts 72 h and more. At patients at whom processing of a wound was carried out by solution Dekasang , noted reduction of severity of pain, hypostasis of fabrics, early sanitation of a wound and early emergence in a granulation wound. The algorithm of treatment of sepsis offered by authors includes an integrated approach to treatment of an infection by early surgical intervention, intensive maintenance therapy, causal antibacterial treatment and topical administration of antiseptic therapy by solution Dekasang . The conclusion was as a result drawn that Dekasang can be recommended for disinfection of skin, mucous membranes and wounds in the centers of the infections caused by bacteria, mushrooms and protozoa (Fuss J., 2016).

to treatment of a burn disease. In one of clinical trials the etiology of infectious complications at 71 patients with burns of heavy degree was established. It is established that the main contagiums at patients with a burn disease are S. aureus (35.9%), A. baumannii (25%), P. aeruginosa (12.82%), P. mirabilis (5.12%). The effective bactericidal activity of antiseptic solutions Dekasana , a miramistina, a chlorhexidina is proved. Concerning staphylococcus high antimicrobic properties of dressing materials which part ions of decamethoxynum, a chlorhexidin, a furagin, silver are are noted. Clinical performance of use of the materials impregnated with antimicrobic structure decamethoxynum with carboxymethylstarch, hydroxyethylcellulose and polyvinyl acetate, applied to prevention and treatment of infectious and pyoinflammatory complications at patients with burns is proved (Nazarchuk O.A., 2016).

B other research provided results of observation of 154 patients with an open craniocereberal injury. The efficiency of decamethoxynum at patients with pyoinflammatory complications was confirmed (Pedachenko E.G. et al., 1992).

as an antiseptic agent in surgery. So, in clinical trial advantages of its application in treatment of purulent processes on a brush (Kravets V.P., 1987) and in complex treatment of the complicated forms a paronychia were shown (Palii G.K. et al., 1988).

in one research in which 286 patients with pyoinflammatory diseases of fingers and brushes (196 patients (68.5%) — with a felon, 82 (28.7%) — with phlegmons and abscesses, 6 (2.1%) — with furuncles and 2 participated (0.7%) — with an anthrax) confirmed efficiency of use of decamethoxynum as a part of complex treatment of this pathology (Fishchenko A. et al., 1992).

Dekametoksin showed to

efficiency and in otolaryngology. In clinical trials the efficiency of use of decamethoxynum at inhalation introduction in treatment of nonspecific diseases of a respiratory path at children was shown (Kravets A.A. et al., 1976).

efficiency in treatment of diseases of a mucous membrane of an oral cavity (Palii G.K. et al., 1975) and also in treatment of an adenoid disease (Zubovich A.P., 1978). In researches the sensitivity of the pathogenic microflora allocated at children with diseases of a respiratory path to decamethoxynum was defined (Palii G.K., 1974). Decamethoxynum can be applied to preoperative training of patients with nonspecific diseases of respiratory organs (Iukhimets V.A., 1985).

in treatment of pyoinflammatory diseases of respiratory organs (Radionov B.V. et al., 1986). The efficiency of decamethoxynum in complex treatment of chronic bronchitis is also confirmed with clinical trials. 72 patients with chronic bronchitis (the catarrhal, purulent and also purulent bronchitis complicated by purulent destructive processes) participated in a research. All patients received complex therapy using decamethoxynum as local antibacterial agent. In this research it is established that inclusion in complex therapy of decamethoxynum is effective not only due to its direct antiseptic action, but also that this medicine reduces resistance of microorganisms to antibiotics (Iukhimets V.A., Pilipchuk V.N., 1990).

Dekasang has very wide range of indications. So, use of decamethoxynum in complex therapy of chronic gastritis in combination with pathology of biliary tract was offered (Mokhun’ I.K. et al., 1982).

Now special attention is paid by

to safety of application of local antiseptic agents and their influence on a cellular cycle and also such indicators as fragmentation of DNA and apoptosis. In a research on rats it was shown that Dekasang at higher antimicrobic efficiency is safer antiseptic agent, than miramistin. It is shown by means of a flowing tsitometriya that decamethoxynum had the minimum proapoptichesky impact on cells of a cornea of rats after 2 weeks of use of medicine. Also it was noted that decrease in proliferation of cages was insignificant, as well as increase in fragmentation of nuclear DNA. It demonstrates to lack of cytotoxic effect of decamethoxynum. When studying similar parameters after application of a miramistin the decrease in mitotic activity of cages, significant increase in fragmentation of DNA and increase in apoptosis was revealed that testifies to higher profile of safety of decamethoxynum in comparison with miramistiny.

conducted a morphological research for studying local action on fabric. Special textiles were impregnated with decamethoxynum mix with the modified polysaccharides. On the basis of results of a research it was established that toxic effect of the antiseptic medical textiles impregnated with decamethoxynum on fabric of a macroorganism is absent. In the same time the positive effect on a course of regenerative processes, epithelization of wounds, antiedematous and anti-inflammatory action was observed (Nazarchuk O.A., 2013).

Conclusions

Dekasang — the antiseptic agent shown to application at a wide range of infectious and inflammatory diseases. Its efficiency and safety are confirmed in clinical trials. Use Dekasang for local sanitation of the center of an infection allows to reduce need for application of antibiotics and also to increase sensitivity of microorganisms to antibiotics at their combined application with Dekasany . This medicine has no toxic effect. The only contraindication to application is the individual intolerance of decamethoxynum. There are no restrictions on application Dekasang during pregnancy and feeding by a breast. As the surface-active cationic antiseptic agent Dekasang is incompatible with soap and other anion surfactants.