Bisoprolol of the tab. of 5 mg No. 30

tablets Biprolol are shown at:

• arterial hypertension;
• coronary heart disease (stenocardia);
• chronic heart failure with systolic dysfunction of a left ventricle in combination with APF inhibitors, diuretics, in case of need - cardiac glycosides.

Structure

Active ingredient: bisoprolol;

1 tablet supports a bisoprolol of the fumarat in terms of 100% substance of 5 mg or 10 mg;

Excipients: lactoses monohydrate, cellulose microcrystalline, calcium hydrophosphate, krospovidon, silicon dioxide colloidal anhydrous, yellow decline of FCF (E 110), magnesium stearate.

Contraindication

• an acute heart failure or heart failure in a condition of a decompensation that demands inotropic therapy;
• cardiogenic shock;
• blockade of II and III degree (except for such at patients with an artificial pacemaker);
• sick sinus syndrome;
• sinuatrial blockade;
• symptomatic bradycardia;
• symptomatic arterial hypotension;
• severe form of bronchial asthma;
• late stages of disturbance of peripheric circulation or Raynaud's disease;
• metabolic acidosis;
• hypersensitivity to a bisoprolol or to other components of drug.

Route of administration

Tablet of the medicament Bisoprol® without chewing, in the morning on an empty stomach, in time or after a breakfast, washing down with a small amount of liquid.

Maximum recommended dose of a bisoprolol of the fumarat makes 10 mg of 1 times a day.

Feature of use

Pregnant women

during pregnancy use medicament only when the expected advantage for mother exceeds potential risk for a fruit.

Children

it is not applied.

Drivers

With care.

Overdose

Symptoms. At overdose (for example, a daily dose of 15 mg instead of 7.5 mg) cases of development of atrioventricular block of the III degree, bradycardia and dizziness were recorded. Frequent signs of overdose by β-blockers is bradycardia, arterial hypotension, an acute heart failure, a hypoglycemia and a bronchospasm. Now several cases of overdose at patients with arterial hypertension and/or coronary heart disease are known (the maximum dose - 2000 mg of a bisoprolol). Bradycardia and/or arterial hypotension were noted. All patients recovered. There is a broad variability of individual sensitivity to single a high dose of a bisoprolol, patients with heart failure can be more sensitive to drug. Therefore treatment should be begun with gradual increase in a dosage.

Treatment. At overdose stop medicament treatment and carry out the supporting and symptomatic therapy. There are limited data, bisoprolol difficult gives in to dialysis. At suspicion on overdose according to expected pharmacological action and based on recommendations for other β-blockers it is necessary to consider the following general actions.

Side effects

General disorders. Often an asthenia (at patients with chronic heart failure), fatigue *.
Infrequently an asthenia (at patients with arterial hypertension or coronary heart disease).

* Concerns only patients with arterial hypertension or coronary heart disease. These symptoms usually arise at the beginning of therapy, are mild and disappear within the first 1-2 weeks.

Interaction

Combination which are not recommended to be applied. Treatment of chronic heart failure. Antiarrhytmic means of the I class (for example, quinidine, Disopyramidum, lidocaine, Phenytoinum, flekainid, propafenon): potentiation of effect on AV conductivity and strengthenings of negative inotropic effect is possible.

Combination which should be applied with care. Treatment of arterial hypertension or coronary heart disease (stenocardia). Antiarrhytmic means of the I class (for example, quinidine, Disopyramidum, lidocaine, Phenytoinum, flekainid, propafenon): potentiation of effect on AV conductivity and strengthenings of negative inotropic effect is possible.

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 3 years.