Azitsin's action is similar to effect of its active components.

Azitromitsin is the representative of group of makrolidny antibiotics – the azaleads having a wide range of antimicrobic action. The mechanism of effect of azithromycin consists in inhibition of synthesis of bacterial protein due to linking with a 50S-subunit of ribosomes and prevention of a translocation of peptides in the absence of influence on synthesis of polynucleotides. The resistance to azithromycin can be inborn or acquired. The full cross resistance exists among Streptococcus pneumoniae, beta and hemolytic streptococci of group A, Enterococcus faecalis and Staphylococcus aureus, including metitsillinrezistentny golden staphylococcus (MRSA), to erythromycin, azithromycin, other macroleads and linkozamida.

Indications

Infection caused by the microorganisms sensitive to azithromycin:

• an infection of ENT organs (bacterial pharyngitis / tonsillitis, sinusitis, average otitis);
• respiratory infection (bacterial bronchitis, community-acquired pneumonia);
• an infection of leather and soft tissues the migrating erythema (initial stage of a disease of Lyme), an ugly face, impetigo, secondary pyodermatoses, an acne vulgaris (eels usual) moderate severity;
• an infection, sexually transmitted: the uncomplicated genital infections caused by Chlamydia trachomatis.

Contraindication

• Hypersensitivity to azithromycin and also to other components of medicine or to any other antibiotic of group of macroleads or ketoleads.
• Heavy abnormal liver functions, kidneys.
• should not be applied along with ergot derivatives because of a theoretical possibility of an ergotism.

AZITsIN of ^® to apply

to adults and children with body weight it is more than 45 kg.

Azithromycin to accept

in 1 times a day, not less than in 1 hour prior to or in 2 hours after meal.

In infections of ENT organs, airways, skin and soft tissues (except the chronic migrating erythema): 500 mg (1 tablet) a day within 3 days.

In an acne vulgaris the recommended general dose of azithromycin makes 6 g which should be accepted according to the following scheme: 1 tablet on 500 mg of 1 times a day within 3 days, then ‒ 1 tablet on 500 mg once a week within 9 weeks. A dose of the second week it is necessary to take in seven days after the first reception a pill, and 8 subsequent doses should be accepted with intervals in 7 days.

At the migrating erythema: in the 1st day – 1 g a day (2 tablets for 1 time), from the 2nd to the 5th day – 500 mg (1 tablet) a day.

In infections, sexually transmitted: 1 g (2 tablets) once. A course dose – 1 g

in case of the admission of reception of 1 medicament dose should accept the passed dose as soon as possible, and the subsequent – with an interval of 24 hours.

Overdose

Symptoms: symptoms of the general intoxication, disorder of hearing, an abdominal pain, severe nausea, vomiting, diarrhea are possible.

Treatment: to wash out a stomach, to accept activated carbon, to carry out the symptomatic therapy directed to maintenance of vital signs of an organism. There is no specific antidote.

Special instructions

Use during pregnancy or feeding by a breast

Pregnancy.

Research of influence on reproductive function of animals at introduction of the doses corresponding to moderately toxic doses for a maternal organism. In these researches the evidence of toxic influence of azithromycin on a fruit was not obtained. However there are no adequate and well controlled researches at pregnant women. As researches of influence on reproductive function of animals not always correspond to effect at the person, it is necessary to appoint azithromycin during pregnancy only according to vital indications.

Feeding by a breast.

It was reported, that azithromycin gets into breast milk, but corresponding and properly controlled clinical trials which would give the chance to characterize pharmacokinetics of excretion of azithromycin in breast milk, was not carried out. Use of azithromycin during feeding by a breast perhaps only in cases when the expected advantage for mother exceeds potential risk for the child.

Fertility.

Research of fertility was conducted on rats; the indicator of pregnancy decreased after administration of azithromycin. The relevance of these data on the person is unknown.

AZITsIN of ^® in this dosage form to apply

to children with body weight it is more than 45 kg.

to Children with body weight to a mensha of 45 kg recommends to apply

azithromycin in other dosage form.

Ability to influence speed of response at control of motor transport or other mechanisms

Considering a possibility of development of side reactions, such as dizziness, drowsiness, disorder of vision, it is not recommended to apply medicine at control of motor transport or work with other mechanisms.

Structure

active ingredient: azithromycin;

1 tablet contains dihydrate azithromycin in terms of azithromycin 500 mg;

excipients: lactose monohydrate, sodium lauryl sulfate, povidone, sodium of a kroskarmelloz, cellulose microcrystalline, magnesium stearate, talc, macrogoal 4000, sepifilm 752 white.

to Store

out of children's reach in original packing at a temperature not above 25 °C.

Expiration date - 3 years.