mechanism of antimicrobial effect of sulphathiazole including oppression of growth and reproduction of microorganisms, it is connected with competitive antagonism with paraaminobenzoic acid and suppression of a digidropteroatsintetaza that leads to disorder of process of synthesis of dihydrofolic acid and, finally, its active metabolite - the tetrahydrofolic acid necessary for synthesis of purines and pyrimidines of a microbic cell.

Sulphathiazole of silver possesses a wide range of antibacterial action against the mixed flora (gram-positive and gram-negative microorganisms), including Pseudomonas aeruginosa.

and considerably the infecting ability of viruses of herpes outside a cell and a virus of herpes a zoster reduces.

Drug effectively protects a wound from infection, forms a protective layer on a wound surface, maintains adequate humidity and promotes wound healing.

Feature

Sulphathiazole of silver has the lowest degree of solubility among other silver salts of group of streptocides and also high stability. Low degree of solubility and high stability of sulphathiazole of silver allows to remain on the surface of the affected skin and to reduce absorption in blood. The absorbed sulphathiazole is acetylated in a liver then it is removed with urine in the form of inactive metabolites and partially - in not changed look. Absorption of sulphathiazole increases after use of medicament by considerable sites of the affected skin.

Indications

Argosulfan® locally to treatment of infections in such cases as:

• skin burns of all degrees (including radiations)
• decubituses;
• trophic ulcers of a shin.

Contraindication

Hypersensitivity to sulphathiazole, in other streptocides or to excipients.

Argosulfan® should not be applied:

• feeding by a breast
• to premature newborns and babies aged up to two months because of risk of hypodermic jaundice (kernicterus)
• sick with congenital deficit glyukozo-6-fosfatdegidrogenazy because of risk of hemolytic anemia.

Route of administration and doses

Use in burns.

for topical administration as in the open way, and with use of occlusive bandages. Argosulfan ^® does not cause darkening of skin and linen.

After cleaning and surgical treatment of a wound cream is put with a layer of 2-3 mm, meeting sterility conditions. All affected areas of skin have to be covered with cream during the entire period of treatment. If for any reason a part of a wound is covered with cream, it is necessary to apply a thin film of medicament always in addition. There is no need to apply an occlusive bandage to a wound, except cases when there are indications for use of a bandage. To apply cream to a complete wound healing or till the moment when the surface of a wound is prepared ​​ for skin transplantation (surgical interventions).

Treatment of decubituses and trophic ulcers of a shin.

Drug are applied with a thin layer on affected areas of skin by 2-3 times a day.

in case of putting medicament on contaminated wounds exudate can appear. In such cases before use of cream it is necessary to wash a wound of 0.1% with aqueous solution of a chlorhexidin, 3% aqueous solution of boric acid or other antiseptic agent. For adults the control of dosing is not obligatory.

cross hypersensitivity to sulphonylurea derivatives, a benzotiazin and r-aminosalicylic acid Is possible

. In each case it is necessary to collect carefully the allergological anamnesis, especially in the relation to streptocides. To avoid contact of medicine with eyes and mucous membranes. In case of accidental hit to wash out enough water. Development of the undesirable and system side effects characteristic for streptocides is also possible.

With care to use medicament to the patients who is in a state of shock after extensive burns and patients after burns to which it is difficult to contact. Cumulation of medicament and emergence of side reactions at patients with an abnormal liver function and kidneys is possible. Against the background of prolonged use on big sites of skin it is necessary to control sulphathiazole level in blood serum, especially in diseases of kidneys and a liver and also the level of leukocytes as development of an agranulocytosis or anemia is possible.

not to use other local drugs.

Should avoid long use.

Argosulfan® contains excipients, including cetostearyl alcohol, propilparagidroksibenzoat and methylparaben. Because of the content of cetostearyl alcohol medicament can cause local reaction of skin (for example contact dermatitis). Because of contents propilparagidroksibenzoat and methylparaben medicament can cause allergic reactions (possible reactions of late type).

Structure

active ingredient: silver sulphathiazole;

1 g of medicament 20 mg

excipients: liquid paraffin, cetostearyl alcohol, paraffin white soft, sodium lauryl sulfate, glycerin, propilparagidroksibenzoat (E 216), methylparahydroxybenzoate

(E 218), potassium dihydrophosphate, hydrophosphate sodium dodecahydrate, water for injections.

to Store

at a temperature not above 25 °C. Not to freeze.

Expiration date - 2 years.