Fungin Forte Sprey for treatment depriving of Apicenna and other fungal diseases Fungin Forte appoint to dogs and cats for treatment of fungal diseases of skin, eczemas of a fungal etiology and seboreyny dermatitis. General information Trade name of medicine: Fungin Forte. International non-proprietary name: terbinafin, thiabendazole, metronidazole, lidocaine, dexamethasone. Dosage form: solution for external application. Fungin Forte as active ingredient contains in 1 ml: a terbinafina of a hydrochloride – 10 mg, tiaben-a dazola – 10 mg, metronidazole – 10 mg, hydrochloride lidocaine – 50 mg, dexamethasone sodium phosphate – 1 mg, and as excipients: benzylic alcohol – 300 mg, a dimethyl sulfoxide – 100 mg, orange terpene – 5 mg and on - lietilenglikol-400 – up to 1 ml. On appearance medicine represents solution from light yellow till dark yellow color. Produce Fungin Forte in glass bottles 10, 12 and 15 ml corked by rubber traffic jams with allyuminiye-vy caps; in polymeric bottles with mechanical raspylitelny heads on 20, 30, 40 and 50 ml or in on - limerny bottles with covers droppers with control of the first opening on 10, 12 and 15 ml. Each consumer packing is supplied with the instruction for application. Store medicine in the closed packing of the producer, separately from foodstuff and forages, in the dry, protected from direct sunshine place at a temperature from 0 °C to 25 °C. An expiration date of Fungin Forte at observance of storage conditions in the closed packing of the producer – 2 years from the date of production, after opening of a bottle – 30 days. Fungin Forte application after an expiration date is forbidden. Fungin Forte it is necessary to store in the places inaccessible for children. Unused medicine is utilized according to requirements of the legislation. Pharmacological properties Fungin Forte treats the combined antimicrobial medicines. Terbinafin – antifungal means of group of allylamines, is active concerning activators of dermatomikoz zhi-cotton. The mechanism of action consists in suppression of a skvalenepoksidaza in a cellular membrane of a mushroom. It results in deficiency an ergosterol and to intracellular accumulation of squalene that causes death of a cage of the activator. Depending on concentration terbinafin shows fungicide or fungistatic effect. Thanks to a high lipofilnost of a molecule of a terbinafin, terms, hair follicles, sebaceous glands collect in a corneal layer; at local at - meneniya medicine gets into a system blood-groove in insignificant degree. Thiabendazole – fungicide from a class azofishing. It is active concerning causative agents of a trichophytia and microsporia of the animal sorts Trichophyton, Microsporum, Epidermophyton, Achorion. As well as other azola, blocks activity of the enzymes participating in 14 demethylation of a lanosterol that leads to violation of synthesis of an ergosterol. Change of structure of a cytoplasmatic membrane of fungal cages leads to violation of its permeability, an exit from a cell of biologically active agents and to destruction of a cellular wall. Besides, thiabendazole breaks nuclear fission process, brakes reproductive a way - a nost of mushrooms. Metronidazole – medicine from group of nitroimidazoles. The mechanism of action consists in biochemical restoration 5 nitrogroups of metronidazole intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5 nitrogroup of metronidazole interacts with DNA of a bacterial cage, inhibiting in it synthesis nukle-inovy acids that leads to death of a microorganism. Dexamethasone – a synthetic glucocorticosteroid, metilirovanny derivative a ftorprednizolona. Renders protivo-the inflammatory, antiallergic, desensibilizing, immunosuppressive, antishock and anti-toxic action, increases sensitivity of beta adrenoceptors to endogenous catecholamines. The action mechanism deksame-a tazona consists in suppression of activity of various enzymes destroying fabrics – proteases and nucleases, matriksny metalproteinases, a gialuronidaza, a phospholipase, slowing down of synthesis of prostaglandins, kinin, leukotrienes and other mediators of inflammation from arachidonic acid. Lidocaine – possesses mestnoanesteziruyushchy action, blocks potentsialzavisimy sodium channels that interferes with generation of impulses in the terminations of sensitive nerves and to carrying out impulses on nervous fibers. Fungin Forte on extent of impact on an organism treats low-dangerous substances (the 4th hazard class in accordance with GOST 12.1.007-76), in the recommended doses does not render local irritative, resorptive and toxic and sensibiliziruyushche-go action. At hit in eyes causes weak irritation. Fungin Forte appoint to dogs and cats for treatment of fungal diseases of skin, eczemas of a fungal etiology and seboreyny dermatitis. A contraindication to application is the hypersensitivity of an animal to medicine components. Ne the weakened animals feeding and pregnant females and also puppies and kittens more young than 4 weeks age are subject to processing. Fungin Forte put with a thin layer by means of a cotton and gauze tampon and also spraying or applying neposred-stvenno to skin from a bottle dropper, slightly rubbing in the struck places from the periphery to the center with capture up to 1 cm of boundary healthy skin. Processings carry out one-two times a day to clinical recovery, but no more than 15 days which is confirmed with microscopic researches of scrapes of skin. Dlya of prevention of a slizyvaniye of medicine an animal muzzle, a collar or close chelyu-st a loop from a tape which remove in 15 – 20 minutes after processing. At the heavy course of a disease of an animal in addition appoint medicines specific and this - ptomatichesky therapy according to instructions for application. Symptoms of overdose are not revealed. Features of action at the first use of medicine and at its cancellation are not revealed. In case of the admission of the next processing the use of medicine is resumed in the same dose, according to the same scheme. The order of application of By-effects and complications at use of medicine Fungin Forte according to the present instruction not on - blyudatsya. At the increased individual sensitivity of an animal to components of medicine and emergence of signs of irritation of skin, processing is stopped, Fungin Forte removed a tampon and washed away water, appoint to an animal antihistaminic medicines and means of symptomatic therapy. Ne should be applied Fungin Forte along with other medicines for local application containing corticosteroid hormones. Fungin Forte is not intended for application to productive animals date editing the description: 28.09.2020