Pharmacological properties

Sumatriptan (3-[2 (dimethylamines) ethyl] - m-skatole-5-metansulfonamida succinate) — means for stopping of attacks of migraine, selection agonist of 5nt1-receptors of serotonin. does not influence serotoninovy receptors of other subtypes and also adrenergic, benzodiazepine, muskarinovy, dopamine receptors. has selective vasoconstrictive effect on vessels of a system of the carotid supplying with blood ekstrakranialny and intracranial fabrics, including a meninx without influencing at the same time a brain blood stream. expansion of these vessels is the main mechanism of development of a migrenozny attack. the clinical effect of medicament occurs in 15–30 min. after reception.

After intake sumatriptan it is quickly soaked up in a digestive tract, in 45 min. its concentration in blood serum reaches 70% of maximum. Bioavailability at oral administration — about 14% due to presistemny metabolism and incomplete absorption in intestines. Linking with proteins of blood plasma low — 14–21%.

Indication

Stopping of attacks of migraine with aura or without it.

Use

Adult is appointed on 1 tablet (100 mg), at some patients the therapeutic dose can make 50 mg (1/2 tablets). at repeated emergence of symptoms medicament it is possible to appoint in additional doses with an interval not less than 1 h the maximum daily dose makes 300 mg. antimigren it is recommended to apply as soon as possible at emergence of an attack of migraine, but it is equally effective in any stage of an attack. medicament cannot be used with the preventive purpose during the mezhpristupny period of migraine.

Contraindication

Ischemic heart disease (stenocardia, a myocardial infarction in the anamnesis), ag, a concomitant use of the medicaments containing ergotamine or its derivatives, Mao's inhibitors and the period up to 14 days after their cancellation, the period of pregnancy and feeding by a breast, the age up to 14 years is also more senior than 60 years, hypersensitivity to drug.

Side effects

At some patients nausea, vomiting, dizziness, weakness, feeling of squeezing which can arise in any part of a body, including a thorax and a throat, increase hell, bradycardia or tachycardia, allergic reactions (rash, urticaria, an erythema). the specified symptoms are short-term.

Drug patients should not appoint

with pathology of a cardiovascular system. it is necessary to apply with care at patients with epilepsy or organic lesions of a brain in the anamnesis in which reduction of the threshold of convulsive activity is possible. with care appoint also to drivers of vehicles and persons whose work demands exact coordination of movements.

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Interaction

Interaction with propranolol, flunariziny and ethanol it is not revealed. interaction with the medicaments containing ergotamine or its derivatives and also with Mao's inhibitors is possible. it is necessary to observe a 24-hour interval between intake of ergotamine and a sumatriptan.

increase in severity of side effects Is possible

. carry out symptomatic therapy.

Storage conditions

B the dry, protected from light place.