Solution for infusions Angio-Betargin is appointed at the following indications:

• metabolic alkalosis;
• a giperammoniyemiya;
• atherosclerosis of vessels of heart and brain;
• atherosclerosis of peripheral vessels, including with manifestations of the alternating lameness;
• a diabetic angiopatiya;
• arterial hypertension;
• chronic heart failure;
• a hypercholesterolemia;
• chronic obstructive diseases of lungs;
• pulmonary hypertensia;
• to an arrest of development of a fruit and a preeclampsia – as a part of complex therapy.

Structure

Active ingredient: arginine hydrochloride.

: arginine of a hydrochloride of 4.2 g;

Excipient: water for injections.

Ionic structure on 1000 ml of drug: With ₆ N ₁₄ N ₄ O ₂ – 200 mmol; Cl ^- – 200 mmol.

Contraindication

Hypersensitivity to drug. Heavy renal failures, giperkhloremichesky acidosis; allergic reactions in the anamnesis; use of kaliysberegayushchy diuretics and also Spironolactonum; a myocardial infarction (including in the anamnesis).

Route of administration

to administer the Drug intravenously by drop infusion with a speed of 10 thaws a minute within the first 10–15 minutes, then it is possible to increase rate of administering to 30 drops a minute.

Daily dose of medicament – 100 ml of solution.

At heavy disturbances of blood circulation in the central and peripheral vessels, at the expressed phenomena of intoxication, a hypoxia, asthenic states a dose of medicament it is possible to increase to 200 ml a day.

Maximum rate of administering of infusion solution should not exceed 20 mmol/h

to Children to 12 years a dose of medicament is 5–10 ml on 1 kg of body weight a day.

Feature of use

Pregnant

Drug gets through a placenta therefore during pregnancy it can be applied only when the expected advantage for mother exceeds potential risk for a fruit.

Children

children can use Drug of 3 years.

Drivers

during control of motor transport or works with other mechanisms should be careful as medicament can cause dizziness.

Overdose

Symptoms: renal failure, hypoglycemia, metabolic acidosis.

Treatment. In case of overdose the infusion of medicament needs to be stopped. It is necessary to carry out monitoring of physiological reactions and maintenance of vital signs of an organism. If necessary to enter alkalizing means and means for adjustment of a diuresis (saluretics), solutions of electrolytes (0.9% solution of sodium of chloride, 5% glucose solution). Symptomatic therapy.

Side effects

• General disorders: the hyperthermia, feeling of heat, an ache are obese.
• from a musculoskeletal system: joint pain.
• from a digestive tract: dryness in a mouth, nausea, vomiting.
• from skin and hypodermic cellulose: changes in the injection site, including hyperaemia, feeling of an itching, pallor of skin, up to a Crocq's disease.
• from the immune system: an acute anaphylaxis, reactions of hypersensitivity, including rash, urticaria, a Quincke's disease.
• from the respiratory system, bodies of a thorax and mediastinum: asthma.
• from a cardiovascular system: fluctuations of arterial blood pressure, change of a warm rhythm, pain in heart.
• from nervous system: the headache, dizziness, sensation of fear, weakness, spasms, a tremor, is more often when speeding introduction.

Interaction

At Angio-Betargin's use needs to be considered that medicament can cause the expressed and resistant hyperpotassemia against the background of a renal failure in the patients accepting or accepting Spironolactonum. Preliminary use of kaliysberegayushchy diuretics can also promote increase in potassium concentration in blood. At simultaneous use with Aminophyllinum the increase in level of insulin in blood is possible.

with thiopental.

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 2 years.