Pharmacological properties

Pharmacodynamics. properties of medicine are caused by effect of three of its active ingredients — Hexetidinum, sincaline of salicylate, gemigidrat chlorbutanol.

Antibacterial and antifungal action is caused by Hexetidinum which shows antibacterial activity concerning gram-positive and gram-negative microorganisms (both aerobes, and anaerobe bacterias). Concerning aerobic microorganisms it has generally bacteriostatic impact and weak bactericidal. Hexetidinum renders the expressed bactericidal effect on anaerobic microorganisms. The mechanism of effect of Hexetidinum is based on competitive substitution of thiamine: the structure of Hexetidinum is similar to structure of the thiamine necessary for growth of microorganisms.

Anti-inflammatory action is caused by sincaline salicylate which belongs to the NPVP group and renders analgeziruyushchy, febrifugal and anti-inflammatory effects.

Anesthetizing activity is caused by also local anesthetic the chlorbutanol applied in otolaryngology (drops in a nose, rinsings) and stomatology (applique and irrigation) generally as sedative.

Pharmacokinetics. Active agents are fixed on a mucous membrane of an oral cavity from where then are gradually released.

Indication

Topical treatment of diseases and inflammatory processes of a mouth and throat at adults and children is more senior than 2.5 years: ulitis, stomatitis; periodontal disease; afta and pain at a teething; postoperative oral cavity care; tonsillitis, sharp and adenoid disease, pharyngitis, laryngitis.

Use

Solution is applied as local means to rinsing of an oral cavity.

For one rinsing of an oral cavity: To dissolve 2 teaspoons of medicine in ¼ glasses of warm water. From 2 to 4 rinsings a day. Not to swallow.

Spray is applied to irrigation of an oral cavity.

Adult: 1 dispersion 4–6 times a day

to Children aged from 2.5 up to 15 years: 1 dispersion 2–3 times a day.

Course of treatment — no more than 5 days.

not to apply

Contraindication

at children aged 2.5 years are younger. not to use in case of detection of an allergy to medicine components.

Side effects

Allergic reactions: irritation, skin reactions. in this case treatment needs to be stopped.

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Special instructions

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does not recommend prolonged use as it can lead to disturbance of microbic balance in an oral cavity and a throat.

Use during pregnancy or feeding by a breast. During pregnancy and feeding by a breast medicament is used only on doctor's orders and only if the advantage of use of medicine for mother exceeds risk for a fruit.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Does not influence.

Children. Apply at children aged 2.5 years are more senior. Safety of use of medicine for children is younger than 2.5 years is not investigated.

not to apply

Interaction

along with the medicines containing antiseptic agents.

Overdose

Messages about overdose of medicine did not arrive.

Storage conditions

At a temperature not above 25 °C. not to freeze.

Relevant information

Angilex is the medicine which is often appointed by otolaryngologists, stomatologists and general practitioners. treats to group of the medicines applied at throat diseases it is released from drugstores without prescription of the doctor.

following active ingredients are its part (according to the instruction of MZU): Hexetidinum, sincaline salicylate, chlorbutanol gemigidrat. Is issued in the form of spray and solution for an oral cavity.

Principles of application, the mechanism of effect of the medicine Angilex

Angilex — the medicine rendering the local antiseptic, anti-inflammatory, anesthetizing action. Its active ingredient Hexetidinum affects bacteriostatically aerobic microorganisms, bactericidal effect weak. And here on anaerobe bacterias works bakteritsidno. The mechanism of action consists in competitive interaction with thiamine: in the chemical structure Hexetidinum is similar to the thiamine necessary for growth of microorganisms. The anti-inflammatory and anesthetizing effects are implemented due to COG enzyme blockade. Sincaline salicylate is responsible for anti-inflammatory activity of medicine, also has analgeziruyushchy and febrifugal effect. The analgesic effect is provided with chlorbutanol.

Use of the medicine Angilex is reasonable

in complex therapy at inflammatory diseases of a stomatopharynx, for example, tonsillitis, pharyngitis. Angilex it is effective at parodont diseases, stomatitis, fungal infections of an oral cavity (complex therapy). It is appointed as a part of complex therapy of a SARS (at a sore throat).

Therapeutic effect of active components of the medicine Angilex

Hexetidinum

Hexetidinum is an antiseptic agent, derivative a pyrimidine, its efficiency and safety at topical administration are confirmed in many researches.

Anti-virus properties of Hexetidinum at respiratory infections and a herpes virus, were studied by in vitro. It was established that Hexetidinum netsitotoksichen for cells of the person, however weakens action of highly virulent influenza viruses of A/H5N1, A/H1N1pdm, RS of a virus and virus of a herpes simplex of the 1st type by 100 times and more. Hexetidinum has such properties even at its short-term application (during 30 c) (P.G. Deryabin, etc., 2016).

B one of researches studied therapeutic action of 0.1% of solution and 0.2% of aerosol of Hexetidinum for topical administration. It was established that Hexetidinum is a safe antiseptic agent with a wide range of antibacterial activity of in vitro and in vivo. Also possesses mestnoanesteziruyushchy, knitting and deodorizing effects. Besides, interferes with formation of microbic biofilms. Pathogenic microorganisms have low resistance to Hexetidinum (Capic E. et al, 2002). The above characteristics of Hexetidinum explain efficiency of the medicine Angilex and its appointment in therapy of infections of an oral cavity and throat.

B one of researches compared efficiency of 0.1% of Hexetidinum and 0.1% of a chlorhexidin in the form of solution for rinsing of an oral cavity. These solutions were appointed the patient with an ulitis or periodontitis. The therapeutic effectiveness and side effects of both medicines were studied. As a result of a research the following conclusions were drawn: solution of Hexetidinum is an alternative to solution of a chlorhexidin as during therapy of the above-stated diseases is not less effective. Side effects of both substances were similar, however Hexetidinum to a lesser extent influenced discolorations of adamantine substance of tooth (Ernst C.P. et al., 2005).

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However, appointing the medicines containing Hexetidinum it is necessary to consider that there are researches which confirm a large amount of side effects at use of Hexetidinum. In them Hexetidinum was compared to placebo and chlorhexidiny at treatment of an ulitis. Authors of rather new researches focus attention on what after all should be applied chlorhexidin as he is better had by patients (Afennich F. et al., 2011). At the same time in the research devoted to comparison of therapeutic effectiveness of a flukonazol and Hexetidinum as local therapy of candidiasis of an oral cavity at patients with dentures it was revealed that Hexetidinum is better transferred by patients, than flukonazol, and causes smaller amount of side effects. Therapy of candidiasis of an oral cavity Hexetidinum was effective and, considering its big safety, it was recommended to appoint Hexetidinum (Koray M. at al., 2005).

Hexetidinum was studied by

In dental practice as medicine for prevention of development of caries. It reduces formation of a dental plaque. The active agents applied to prevention of caries have to prevent formation of a biofilm of pathogenic bacteriums, without affecting biological equilibrium of microflora of an oral cavity. Prescribing of germicides first of all is characteristic at secondary and tertiary prevention (for the purpose of prevention of recolonization by pathogenic microorganisms) of prevention of a recurrence of a disease. Results of these researches demonstrate that Hexetidinum is capable to inhibit development and maturing of a pathogenic biofilm and also to influence metabolism of bacteria (Baehni P.C., Takeuchi Y., 2003).

Naddesnevy dental plaque (dental calculus) is one of problems in stomatology. Reduction of its education is a key moment of prevention of caries and diseases of the parodont. Only mechanical removal of a dental plaque during toothbrushing is not always effective. Properties of Hexetidinum to inhibit formation of a dental plaque were investigated by group of the European scientists. By results of researches conclusions are drawn that Hexetidinum slows down formation of a dental plaque therefore it is applied as prevention of development of an ulitis and also has anti-inflammatory effect and, therefore, can be applied in complex therapy of this disease. Also conclusions were drawn on safety of medicine for broad clinical use. Hexetidinum is effective against C. albicans often colonizing dentures. It is also established that Hexetidinum can be applied in dental practice as in the form of solution to rinsing of an oral cavity, and in the form of oral spray. For prevention of colonization of dentures pathogenic microorganisms it was offered to process them, having shipped in 0.1% Hexetidinum solution for the night (8 h) (Aoun G et al., 2005).

Pathogenic microorganisms are

reason of development of inflammatory processes of an oral cavity and throat. In one of researches conducted by in vitro the activity of 4 antiseptic agents (tsetiltrimetilammoniya naproksenat, chlorhexidin, benzydamine, Hexetidinum) was compared to 4 antibiotics (amoxicillin, amoxicillin and clavulanic acid, klaritromitsin, a tsefaklor). Effect of medicines of both groups on the microorganisms colonizing a stomatopharynx and airways including on Streptococcus pyogenes and Streptococcus pneumoniae was studied. This research showed that the chosen group of bacteria was more sensitive to group of antiseptic agents, than to amoxicillin and amoxicillin and clavulanic acid. As a result of a research it is established that the above antiseptic agents can will be applied against pathogenic microorganisms of an oral cavity and throat (Pilloni A.P. et al., 2002).

Hexetidinum was also applied to processing of an endotracheal tube at IVL at patients of intensive care unit. By results of a research conclusions were drawn that resistance of hexetidinsoderzhashchy PVC of 1% to microbic adhesion was higher, than at native PVC. Therefore it is supposed that this method is able to afford to reduce the frequency of developing of ventilyatorassotsiirovanny pneumonia (the special form of pneumonia, arises at the patients who are on IVL) (Jones D.S. et al., 2002).

Holin's

salicylate

Holin's

salicylate is the effective and well transferred by patients anti-inflammatory medicine known from the 60th years of the 20th century when it was applied and as febrifugal medicine (Broh-Kahn Rh., 1960). Sincaline salicylate is applied also to treatment of rheumatic diseases, first of all a pseudorheumatism, as a part of ear, eye drops, to treatment of otitis, an ulitis and elimination of a dental plaque (Scully F.J., 2010).

salicylate positively proved Holin's

in treatment of inflammatory diseases of gums (Brodniewicz Z. et al., 1986), and thanks to the anesthetizing properties — and in treatment of cankers of an oral cavity (Daniel A. et al., 1960).

as effective anti-inflammatory and analgetic medicine of sincaline salicylate is recommended to be included in complex therapy of sharp catarrhal average otitis (A.A. Razvozzhayev, etc., 2012).

B one of researches was irritant action of 2% of sincaline of salicylate in the form of eye drops is studied. Within 5 min. affected with it cells of a cornea of an eye of a rabbit. Then the viability of cages of a cornea was defined. As a result of a research it was established that at medicine low cytotoxicity. After its application the viability of cages was more than 70% (Wroblewska K. et al., 2015).

Interesting research was conducted by

in 1986. Earlier was considered that sincaline salicylate can be appointed to persons from raised sensitivity to acetylsalicylic acid and other NPVP. But cases of development of hypersensitivity and exacerbation of bronchial asthma after intake of sincaline of salicylate were described. Thus, it is possible to draw a conclusion that development of cross-reaction of hypersensitivity is possible (D.S. Chudvin, etc., 1986). Respectively, it is necessary to appoint the medicine Angilex to such patients with extra care.

Also information that use of the medicines containing in the composition of sincaline salicylate for treatment of diseases of an oral cavity can bring to development of refractory stomach ulcer (Lim Y.C exists. et al., 2014). This side effect is especially relevant at self-treatment by the medicines containing this active ingredient. Patients should be informed on a possible canker of digestive tract as side effect of the medicines containing sincaline salicylate and also on danger of their uncontrolled application.

Chlorbutanol's

gemigidrat

Chlorbutanol is a part of some sedative medicines and anesthetics. At application inside has sedative effect. Locally it is appointed as an antiseptic agent, has the distracting effect, moderate anti-inflammatory properties are characteristic.

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At researches of toxicity of chlorbutanol it was revealed that this active ingredient has hypotoxicity. Is a part of a large amount of medicines. However patients should appoint it with extra care with abnormal liver functions and kidneys. Emergence of violation of the speech, a dysarthtia, drowsiness, violation of a hemodynamics is possible. Development of toxic effects is possible at prolonged uncontrolled use of the medicines containing chlorbutanol gemigidrat (Nordt S.P. et al., 1996).

needs to be remembered that in the researches in vitro chlorbutanol made an adverse effect on embryo fabrics of a mouse. In researches on mice it was revealed that it got through a placenta and had toxic effect on fabrics of the developing embryo (Smith W.S. et al., 1997).

Conclusion

Angilex is medicine which active ingredients are picked up in such a way that therapeutic action of everyone is complemented and vzaimousilivatsya. However it is necessary to remember that medicine has contraindications and side effects therefore before its application the consultation of the doctor is necessary, even in spite of the fact that it treats medicaments of non-prescription dispensing.