tablets "Angélique" are applied at the following indications:

• replacement hormonal therapy (RHT) at deficiency symptoms of estrogen at women of the post-menopausal period more than one year after approach of a menopause;
• prevention of osteoporosis at women of the post-menopausal period who enter into group of the increased risk of developing bone fractures and have intolerance of other medicines applied to prevention of osteoporosis or to which such means are contraindicated.

.

Structure

One tablet contains (active ingredients):

• oestradiol (in the form of gemigidrat oestradiol) - 1.0 mg;
• a drospirenon - 2.0 mg.

Excipients: lactoses monohydrate, starch corn, starch prezhelatinizirovanny, povidone 25000, magnesium stearate, hydroksipropilmetiltsellyuloza, macrogoal 6000, talc, titan dioxide (E 171), ferrous oxide red (E 172).

Contraindication

• genital bleedings of not clear etiology;
• a breast cancer, suspicion on it, or presence of the specified pathology in the anamnesis;
• it is oestrogenic - dependent malignant tumors or suspicion on them (for example, endometrial cancer);
• not treated hyperplasia of endometrium;
• a venous thrombembolia or presence of the specified pathology in the anamnesis (deep vein thrombosis, a pulmonary embolism);
• an arterial thrombembolia in the acute stage or postponed recently (for example stenocardia, a myocardial infarction, a stroke);
• high risk of venous or arterial thrombosis;
an acute disease of a liver or a disease of a liver in the anamnesis so far indicators of function of a liver are not normalized by
• ;
• serious illness of a liver;
• available at the moment or in the anamnesis of a tumor of a liver (benign or malignant);
• tendency to development of thromboses (for example, deficiency of a protein With, deficiency of a protein of S or antithrombin);
• renal failure or sharp renal failure;
• insufficiency of adrenal glands;
• known anaphylactic reactions, a Quincke's edema, hypersensitivity to active ingredients or to any of medicine excipients;
• porphyria;
• heavy gipertriglitseridemiya.

If ZGT was appointed by

for the first time or transition to Angélique from the combined medicine for continuous ZGT takes place, then reception of the tablets "Angélique" can be begun at any time. If transition to Angélique from the cyclic combined medicine for ZGT takes place, it is necessary to finish the current cycle of therapy before use of the medicine "Angélique".

Dosage - on one tablet a day. Each packing is expected a 28-day course of treatment.

to take the Pill without chewing, washing down with a small amount of liquid. Treatment is carried out continuously, that is reception of tablets from the following packing is begun right after the end of the previous packing, without any intervals. It is desirable to apply tablets at the same time. If there is a delay in reception of the next tablet, it is necessary to accept it as soon as possible. If the next pill was not taken within more than 24 hours it is not necessary to take an additional pill. If several tablets in a row were passed, bleeding can begin.

by

To treatment of post-menopausal symptoms applies the smallest effective dose.

by

For a start and continuations of therapy of post-menopausal symptoms uses the smallest effective dose during short term.

to

Feature of application

Pregnant

Angélique Medicine is contraindicated to pregnant women and women who nurse.

Children

Drug "Angélique" not ostentatious for application to children and teenagers.

Drivers

Medicine does not influence speed of response at control of motor transport or work with other mechanisms.

Overdose

In the clinical trials conducted with participation of male volunteers well transferred doses up to 100 mg of a drospirenon. Proceeding from the general experience of application of the combined oral contraceptives, it is established that the overdose can make sick, vomiting and vaginal bleedings girls and some women. Specific antidote does not exist, treatment has to be symptomatic.

Side effects

Side reactions about which it was most often reported at use of the medicine "Angélique" were mammary gland pains (> 10%) and within the first months of therapy - bleedings and bloody discharges (> 10%) which usually disappeared in process of treatment continuation. Frequency of bleedings decreases in process of increase in duration of therapy.

to Store

at a temperature not above 25 °C, out of children's reach.

Expiration date - 5 years.