Amlodipin-Astrafarm – antihypertensive medicament for treatment

• arterial hypertension;
• chronic stable stenocardia;
• vasospastic stenocardia (Printsmetal's stenocardia).

Structure

• active ingredient: amlodipine;
• 1 tablet supports an amlodipin of the besilat in terms of 100% substance of 5 mg;
• other components: calcium hydrophosphate, cellulose microcrystalline, magnesium stearate, starch corn.

Contraindication

Hypersensitivity to dihydropyridines, an amlodipin or any other component of medicine.

Arterial hypotension of heavy degree.

Shock (including cardiogenic shock).

Obstruction of an output path of a left ventricle (for example, stenosis of an aorta of heavy degree).

Hemodynamically unstable heart failure after an acute myocardial infarction.

Side reactions

At use of an amlodipin it was most often reported about such side reactions as: drowsiness, dizziness, a headache, the strengthened heartbeat, rushes of blood, an abdominal cavity pain, nausea, hypostases of shins, hypostases and fatigue.

Route of administration

Usually for treatment of arterial hypertension and stenocardia the recommended initial dose makes 5 mg of an amlodipin of 1 times a day. Depending on reaction of the patient to therapy the dose can be increased to the maximum dose making 10 mg of 1 times a day.

to Patients with stenocardia can use medicament as monotherapy or in a combination with other anti-anginal medicines at resistance to nitrates and/or adequate doses of β-blockers.

experience of use of medicament in a combination with thiazide diuretics, - blockers, - blockers or inhibitors of angiotensin-converting enzyme to patients with arterial hypertension Is available.

need for selection of a dose of medicament at simultaneous use with thiazide diuretics, β-blockers and inhibitors of angiotensin-converting enzyme.

Children of 6 years with arterial hypertension.

Recommended initial dose for this category of patients makes 2.5 mg of 1 times a day. If the required ABP level is not reached within 4 weeks, it is possible to increase a dose to 5 mg a day. Use of medicament in doses higher than 5 mg for this category of patients was not investigated.

Safety and efficiency of use of an amlodipin in hypertensive crisis were not estimated by

Feature of use

by

.

is recommended to be Applied amlodipin during pregnancy only when the expected advantage of mother exceeds potential risk for a fruit.

Amlodipin is allocated to

in breast milk. The ratio of the dose received by the newborn from mother in the interquarter range is estimated as 3-7%, at most 15%. Action of an amlodipin on babies is unknown. At making decision on feeding continuation by a breast or uses of an amlodipin it is necessary to estimate advantage of feeding by a breast for the child and advantage of use of medicament for mother.

Children

children can use Drug of 6 years.

aged up to 6 years does not know Influence of an amlodipin on arterial blood pressure of patients.

Ability to influence speed of response at control of motor transport or other mechanisms

Amlodipin can have insignificant or moderate impact on ability to run motor transport or to work with other mechanisms. Speed of response can be reduced in the presence of such symptoms as dizziness, headaches, confusion of consciousness or nausea. It is necessary to be careful, especially at the beginning of therapy.

Experience of deliberate overdose of an amlodipin is limited to

.

Symptoms: the considerable overdose of medicament will lead to an excessive peripheral vazodilatation and, perhaps, reflex tachycardia. It was reported about development of considerable and long system arterial hypotension, including shock with a lethal outcome.

Clinically significant hypotension caused by overdose of an amlodipin demands active support of activity of a cardiovascular system, including frequent monitoring of functions of heart and breath, a raising of extremities, monitoring of volume of the circulating liquid and a mocheotdeleniye.

For restoration of a tone of vessels and the ABP can use vasoconstrictive drugs, having made sure of lack of contraindications to their use. Use of a gluconate of calcium can intravenously be useful to leveling of effects of blockade of calcium channels.

gastric lavage can be in certain cases useful for

. Use of activated carbon to healthy volunteers during 2 h after introduction of 10 mg of an amlodipin considerably reduced the level of its absorption.

As amlodipin substantially contacts proteins of blood plasma, the effect of dialysis is insignificant.

Interaction with other medicines and other types of interactions

Influence of other medicines on amlodipin.

data on safe use of an amlodipin with thiazide diuretics, α-blockers, β-blockers, inhibitors of angiotensin-converting enzyme (APF), nitrates of the prolonged action, a sublingual form of nitroglycerine, nonsteroid anti-inflammatory medicines Are available.

to Store

in original packing at a temperature not over 25C.

to Store

out of children's reach.