Amigren capsules are used to fast simplification of a state at migraine attacks, with aura or without it.

Structure

Active ingredient - sumatriptan (a bottom the capsule supports a sumatriptan of succinate in terms of sumatriptan 50 mg).

Excipients: lactose, monohydrate; microcrystalline cellulose; sodium of a kroskarmelloz; magnesium stearate.

Structure of a cover of the capsule: gelatin, titan dioxide (E 171), ponso 4R (E 124).

Contraindication

• hypersensitivity to medicament components;
• a myocardial infarction in the anamnesis, coronary heart disease, Printsmetal's stenocardia, diseases of peripheral vessels or symptoms characteristic of coronary heart disease;
• a stroke or passing disturbance of cerebral circulation in the anamnesis;
• moderate or heavy arterial hypertension and slight uncontrollable arterial hypertension;
• heavy liver failure;
• simultaneous use of ergotamine or its derivatives (including metizergid);
• simultaneous use of any agonist of triptanes / 5-hydroksitriptamin-receptors (5-HT1);
• competitive prescribing of inhibitors monoamine oxidase (MAO) and medicament "Amigren"; the Amigren capsules should not be used within 2 weeks after cancellation of MAO inhibitors.

Route of administration

Capsule of the medicament "Amigren" cannot be applied for the purpose of prevention of an attack.

Amigren is recommended to be applied as soon as possible after the beginning of an attack of migraine though it is equally effective at each stage of an attack.

Recommended dose of the medicament "Amigren" for adults - 50 mg. In some cases the dose can be raised to 100 mg.

Amigren can be applied at new attacks of migraine, but if the first dose is inefficient, it is not necessary to use medicament repeatedly during the same attack.

to the first dose, but symptoms are restored, the second dose can be applied within the next 24 hours, at the same time the general daily dose should not exceed 300 mg.

Capsule entirely, washing down with water.

Feature of use

Pregnant

is not recommended to apply Amigren to pregnant women. In case of need it is necessary to weigh a ratio of the expected advantage for mother and possible risk for a fruit.

With care is applied during feeding by a breast. It is not recommended to nurse the child within 24 hours after administration of drug.

by

therefore the medicament "Amigren" is not recommended to appoint this category of patients.

Drivers

Drowsiness can turn out to be consequence both migraines, and its Amigren medicament treatment therefore it is necessary to avoid control of motor transport or work with mechanisms during administration of medicament or an attack of migraine.

Overdose

Dose, the exceeding 400 mg (orally), did not make other side effects, except those which are provided below.

Treatment: performing maintenance therapy and observation of the patient not less than 10 hours.

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Side effects

from the immune system: reactions of hypersensitivity - from skin hypersensitivity to anaphylaxis cases.

from nervous system: dizziness; drowsiness; disturbances of sensitivity, including paresthesias and hypesthesias; spasms. Though some of these cases were noted at patients with spasms or with states which can bring to them, in the anamnesis, there are cases of development of spasms in patients without any tendency to them; tremor, dystonia, nystagmus, scotoma.

from mentality: excitement.

from a cardiovascular system: tranzitorny increase in arterial blood pressure right after administration of drug, blood inflow, bradycardia, tachycardia, the strengthened heartbeat, disturbance of a rhythm, passing ischemic changes on the ECG, a spasm of coronary arteries, stenocardia, a myocardial infarction, arterial hypotension, a Raynaud's disease.

from a respiratory system: asthma.

from a digestive tract: the nausea and vomiting arising at some patients, but their communication with use of a sumatriptan it is up to the end not found out; ischemic colitis, diarrhea.

from a musculoskeletal system: heavy feeling, myalgia. The given symptoms usually are passing, can have intensive character and influence any part of a body, including a thorax and a throat; muscle tension of a neck, arthralgia.

from an organ of sight: blinking, diplopia, decrease in visual acuity, loss of sight (usually passing). However disorders of vision can be a consequence of the attack of migraine.

from skin: hyperhidrosis.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 2 years.