tablets "Amantin" are applied at the following indications:

• Parkinson's syndrome: treatment of symptoms of Parkinson's disease, such as rigidity, tremor, hypokinesia and akineziya;
• extrapyramidal side effects of neuroleptics and other medicines: early dyskinesia, akathisia and parkinsonism.

Structure

Active ingredient - an amantadina sulfate (one tablet supports an amantadin of sulfate of 100 mg).

Excipients: lactoses monohydrate, cellulose microcrystalline, potato starch, gelatin, povidone, sodium of a kroskarmelloz, talc, silicon dioxide colloidal anhydrous, magnesium stearate, Opadry II White (polyethyleneglycol, polyvinyl alcohol, talc, titan dioxide (E 171)).

Contraindication

• hypersensitivity to an amantadin or to any component of drug;
• epilepsy and other convulsive attacks;
• heavy renal failure;
• peptic ulcer;
• dekompensirovanny heart failure (a stage of IV according to classification, the developed New York association of cardiologists - NYHA);
• cardiomyopathy and myocarditis;
• blockade of II and III degree;
• bradycardia (less than 55 blows / minute);
• prolonged QT interval (Bazett QTc> 420 ms) or with noticeable U-waves, or with a congenital QT syndrome in the family anamnesis;
• heavy ventricular arrhythmia, including chaotic polymorphic ventricular tachycardia;
• simultaneous treatment budipiny or other medicaments which extend QT interval;
• lowered level of potassium or magnesium in blood.

Route of administration

needs to take the Pill the adult inside, with a small amount of liquid, after a meal, it is desirable in the morning and/or in the afternoon. Due to the potential activating impact on the central nervous system (CNS) the last dose is recommended to be accepted no later than the sixteenth hour.

Following

above-mentioned measures and considering contraindications, can prevent the side reaction menacing for life - chaotic polymorphic ventricular tachycardia.

Treatment of patients with Parkinson's syndrome and disturbances of physical activity, caused by use of medicines, it is necessary to carry out gradually, observing a dosage according to therapeutic effect.

should begin Treatment with

with reception of one tablet (100 mg of an amantadin of sulfate) of the medicament "Amantin" in day in the first 4-7 days with the subsequent increase in a daily dose at one tablet of times a week before achievement of an effective therapeutic dose.

Usually effective dose makes 1-3 tablets two times a day (200-600 mg of an amantadin of sulfate).

to

to Elderly patients, in particular at conditions of agitation, confusion of consciousness or syndromes of a delirium, recommends a daily dose of 100 mg (one tablet). If such dose is not effective, it is possible to increase it carefully to 200 mg a day under observation of the doctor.

At the combined treatment with other protivoparkinsonichesky means a dose should be selected individually.

initial dose has to be higher than

For patients who were treated amantadiny, solution for injections earlier.

needs to appoint by

At sharp deterioration in parkinsonichesky symptoms at akinetic crisis administration of solution of an amantadin of sulfate.

Duration of treatment depends by nature and disease severity and is defined by the doctor. Patients should not interrupt treatment independently.

Should avoid the sharp termination of treatment as in that case at patients with Parkinson's disease strengthening of extrapyramidal symptoms which sometimes include akinetic crisis is possible, and the effect of the termination of reception can sometimes be shown in the form of a delirium.

Pregnant

Amantadin it is contraindicated to the pregnant women and women planning pregnancy to accept

Feature of use

Children

Experience of use of an amantadin to children insufficient therefore medicament do not apply this age category.

Drivers

Amantadin can reduce concentration of attention and speed of reaction, to cause dizziness, decrease in visual acuity therefore patients should be warned about potential danger when driving or during the work with other mechanisms.

Overdose

Always needs to consider a possibility of repeated intoxication, for example reception more than one medicament for the purpose of a suicide.

Symptoms

take the Important place at overdose of an amantadin symptoms of acute toxic psychosis in the form of confusion of consciousness with visual hallucinations that sometimes include a coma and a myoclonia and can be observed after a concomitant use of an amantadin and other protivoparkinsonichesky drugs. Superexcitation, a tremor, an ataxy, misting of sight, a lethargy, a depression, a dysarthtia, neuromuscular disturbances, hyperreflexia, motive concern, spasms, the extrapyramidal phenomena, torsion spasms, expansion of pupils, a dysphagy, confusion of consciousness, a disorientation, a delirium, a myoclonus, nausea, vomiting, dryness in a mouth, a hyperventilation, a fluid lungs, respiratory insufficiency, a respiratory distress syndrome, a hypertension, cardiac arrhythmia, tachycardia, stenocardia attacks, a stop of warm activity. The renal failure, including increase in urea nitrogen and decrease in clearance of creatinine, an ischuria is possible.

Special medicament treatment or antidote are unknown to

. For prevention of absorption of medicament it is necessary to cause vomiting and/or to wash out a stomach (if the patient in consciousness), to apply activated carbon. In case of life-threatening intoxication, resuscitation actions are necessary. It is necessary to host therapeutic actions, to provide maintenance of the vital functions of an organism, adequate hydration, perhaps, a sedation, measures against spasms and arrhythmias.

Side effects

Side reactions on amantadin which more often happen easy degree and have passing character, as a rule, appear within 2-4 days from an initiation of treatment and quickly pass after the termination of administration of drug.

from mentality: often (> 1/100 to <1/10) - a sleep disorder and mental agitation.

from nervous system: often (> 1/100 to <1/10) - motive disturbances.

from the vascular system: often (> 1/100 to <1/10) - orthostatic dysregulation.

from a digestive tract: often (> 1/100 to <1/10) - nausea, dryness in a mouth.

from skin and hypodermic cellulose: often (> 1/100 to <1/10) - the "marble" skin (emergence of a mesh-bluish shade of skin) associated sometimes with hypostasis of an ankle joint.

from an urinogenital system: often (> 1/100 to <1/10) - an ischuria at patients with a prostate hyperplasia, urine incontinence, change of a libido.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.