Albenz – anthelminthic means. The means applied in nematodoses. Benzimidazole derivatives.

Indications

Intestinal forms of helminthoses: an enterobiosis, a dochmiasis, a necatoriasis, a hymenolepiasis, a teniosis, a strongyloidosis, an ascaridosis, a trichuriasis, a clonorchosis, an opisthorchosis, a giardiasis at children.

Structure

• active ingredient: albendazole;
• 5 ml of suspension contain albendazole of 200 mg;
• other components: sucrose; sodium methylparahydroxybenzoate (E 219); sodium propilparagidroksibenzoat (E 217); sodium of a karmeloz; polysorbate 80; citric acid, monohydrate; sodium citrate; silicon dioxide colloidal anhydrous; banana essence; water is purified.

Contraindication

Hypersensitivity to albendazole, other derivative benzimidazoles, other components of drug. Eye retina disease. Period of pregnancy and feeding by a breast. Pregnancy planning. Women of reproductive age should apply effective non-hormonal contraceptive remedies during 1 month after medicament treatment.

Side reactions

from a digestive tract and a liver: stomatitis, dryness in a mouth, heartburn, nausea, vomiting, an abdominal pain, a meteorism, diarrhea, a constipation, tranzitorny increase in activity of liver enzymes, jaundice, hepatitis, hepatocellular disturbances.

from a cardiovascular system: increase in the ABP, tachycardia.

from central nervous system and peripheral nervous system: insomnia or drowsiness, headache, dizziness, confusion of consciousness, disorientation, hallucinations, spasms, decrease in visual acuity.

from blood and lymphatic system: leukopenia; neutropenia; thrombocytopenia; anemia, including aplastic anemia; agranulocytosis, pancytopenia. Patients with a liver disease, including hepatic echinococcosis, are more subject to oppression of marrow.

from skin and hypodermic cellulose: skin rash, hyperaemia, polymorphic erythema, Stephens's syndrome of Johnson, reversible alopecia, dermatitis, hypostasis.

from kidneys and an urinary system: renal failure, OPN, proteinuria.

Allergic reactions: reactions of hypersensitivity, including rash; itching; small tortoiseshell; bladderwort; dermatitis; fever.

General disturbances: ostealgia, throat; fever; weakness.

Route of administration

to

Dose is established by the doctor individually.

to Children from 1 to 2 years in an enterobiosis, a dochmiasis, a necatoriasis, an ascaridosis, a trichuriasis medicament to appoint

on 5 ml of suspension (200 mg) of 1 times a day once.

to Adults and children aged from 2 years in an enterobiosis, a dochmiasis, a necatoriasis, an ascaridosis, a trichuriasis to administer the medicament 10 ml of suspension (400 mg) of 1 times a day once.

At the established diagnosis of a strongyloidosis, teniosis and hymenolepiasis to use medicament to adults and children aged from 2 years on 10 ml of suspension (400 mg) of 1 times a day within 3 days. In a hymenolepiasis the repeated course of treatment in the range from the 10th in 21st put after the previous course is recommended.

to adults and children of 2 years medicament to appoint

In an opisthorchosis and a clonorchosis on 10 ml of suspension (400 mg) 2 times a day within 3 days. The specified scheme is effective also at the mixed invasion of Opisthorhis viverrini and Clonorchis sinensis.

In a giardiasis to children from 2 to 12 years to use medicament on 10 ml of suspension (400 mg) of 1 times a day within 5 days.

to

Use during pregnancy or feeding by a breast

to

Drug is contraindicated to

Feature of use

for use during pregnancy or feeding by a breast and for treatment of women who are going to become pregnant. At use of medicament it is necessary to stop feeding by a breast.

Children to

Drug is contraindicated to

for treatment of children 1 years are younger.

Ability to influence speed of response at control of motor transport or other mechanisms

Considering existence of such side reaction as dizziness, for use of albendazole it is recommended to abstain from control of motor transport and from work with other mechanisms.

Overdose

Symptoms: nausea, vomiting, diarrhea, tachycardia, drowsiness, disorder of vision, visual hallucinations, disturbance of the speech, dizziness, loss of consciousness, increase in a liver, increase in level of transaminases, jaundice; a respiratory distress, a brown-red or orange color of skin, urine, sweat, saliva, tears and excrements it is proportional to the applied medicament dose.

Treatment: to carry out gastric lavage and to perform symptomatic and maintenance therapy.

Interaction with other medicines and other types of interactions

Albendazole induces enzymes of a system of P450 cytochrome.

At simultaneous use with Cimetidinum, prazikvantely and dexamethasone increase in level of metabolites of albendazole in blood plasma is possible

that is responsible for system activity of medicament that can lead to its overdose.

Medicines which can slightly reduce efficiency of albendazole: anticonvulsant medicaments (for example, Phenytoinum, fosfenitoin, carbamazepine, phenobarbital, Primidonum), levamisole, ritonavir.

efficiency of treatment of patients should be controlled, the alternative dose modes or therapy can be required.

Grapefruit juice also increases albendazole sulphoxide level in blood plasma.

Because of possible disturbance of activity of P450 cytochrome the theoretical risk of interaction with the following medicaments exists: oral contraceptives, anticoagulants, oral antihyperglycemic means, theophylline.

At simultaneous use of albendazole with theophylline should control theophylline level in blood.

Concomitant use of medicine and greasy food leads

to increase in absorption of albendazole from a digestive tract.

Storage conditions

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

to Shake up

before use.