Akut cisthinol of the tab. of p/o No. 30

Pharmacological properties

Pharmacodynamics. medicines of leaves of a bearberry in vitro have antibacterial effect concerning proteus vulgaris, e. coli, ureaplasma urealyticum, mycoplasma hominis, staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumoniae, enterococcus faecalis, streptococcus strains and also candida albicans.

with hydrochinone aglikona which are released from arbutin or from the products which are formed at arbutin removal. At release of hydrochinone from conjugates (hydrokhinonovy Glucuronide and sulfate) the enzymatic activity of microorganisms which cause infections of urinary tract is blocked.

at the same time extract of leaves of a bearberry usual due to availability of tannins reduces adhesion of bacteria to a host cell.

Pharmacokinetics. Arbutin of leaves of a bearberry (pro-medicine) is adsorbed in a small intestine and is exposed to fermentation and also is metabolized in a liver. Thereof conjugates of hydrochinone turn by reaction of the second passing to a form of a hydrokhinonovy glucuronide and sulfate. These non-toxic connections are water-soluble and are removed with urine.

In metabolism researches with the assistance of healthy volunteers (Tsistinol Akut, tablets, coated) with urine in the form of the conjugated hydrochinone for 24 h. Restoration of active substance in the form of free hydrochinone was 0.5% of the entered arbutin dose.

In microbiological researches concerning E. coli is established that fermenting of conjugates arises at a wide range of intrabakterialny interaction and does not depend on level rn urine. Besides, antiseptic action increases only on that site where there are bacteria.

Indication

Inflammatory diseases of the lower urinary tract.

Use

to Adults and teenagers is aged more senior than 12 years appoint 2 tablets 3 times a day. tablets need to be washed down with a large amount of liquid, mainly water, to accept after a meal.

If the doctor did not appoint other, then the medicine containing arbutin it is necessary to apply no more than 1 week and no more than 5 times a year.

Children. Do not apply at children aged up to 12 years.

Contraindication

Hypersensitivity to leaves of a bearberry or other components of medicine.

Side effects

carry out the Assessment of side effects on the frequency of their emergence as follows: very often (≥1/10); often (≥1/100 to 1/10); sometimes (≥1/1000 to 1/100); seldom (≥1/10,000 to 1/1000); very seldom (1/10,000); frequency is unknown (it is impossible to estimate according to available data).

Very seldom patients with hypersensitivity of a stomach can complain of symptoms from a digestive tract (nausea, vomiting, an abdominal pain, diarrhea).

from nervous system: dizziness.

such allergic reactions as can Seldom arise: rash, itch.

in case of development of side effects treatment needs to stop and consult with the doctor who will estimate degree of their weight.

Doctor has to make the decision on further actions as required.

Special instructions

At emergence of a hamaturia, fervescence or if complaints remain more than 5 days, it is necessary to consult with the doctor.

Patients with hereditary intolerance of a galactose, a lactose intolerance and glyukozo-galaktozny malabsorption should not use this drug.

Use during pregnancy and feeding by a breast. Do not apply during pregnancy or feeding by a breast.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Does not influence.

Interaction

Tsistinol are anut by tablets, coated, contain extract of leaves of a bearberry and therefore should not be applied together with the medicines increasing acidity of urine as it is impossible to exclude reduction of expressiveness of antibacterial effect of leaves of a bearberry.

Overdose

Symptoms: at use of medicine in the doses exceeding recommended there can be such violations from a digestive tract as vomiting, nausea, a hamaturia and damages of a liver.

Treatment: it is necessary to stop immediately administration of medicament and to see a doctor. Symptomatic therapy.

Storage conditions

In original packing at a temperature not above 25 °C.

out of children's reach.

Exclusive distributor: CIAO Naturfarm, Lesnaya St., 30a, Kiev, Pushcha-Vodytsia, 04075; phone number: (044) 401-81-03.

Supplier: Alpen Pharm AG (Switzerland).