Pharmacological properties

Pharmacodynamics. active ingredient of medicament adaptol Mebicarum on chemical structure is close to natural metabolites of an organism — its molecule consists of two metilirovanny fragments of urea which are a part of bicyclic structure.

Adaptol has moderate tranquilizing (anxiolytic) activity, eliminates or weakens feeling of concern, alarm, fear, internal emotional pressure and irritation. The calming effect of medicament is not followed by muscle relaxation and a lack of coordination of movements. Drug does not reduce intellectual and physical activity therefore Adaptol it is possible to apply during the working day or study. Drug does not cause feeling of high spirits, a feeling of euphoria. On this basis Adaptol carry to day tranquilizers. Has no somnolent effect, but strengthens effect of sleeping medicines and improves a dream at its disturbance.

Krom calming, Adaptol has nootropic effect. Drug improves cognitive functions, increases attention and intellectual working capacity, without stimulating symptomatology of productive psychopathological disorders — nonsense, pathological emotional activity.

Adaptol has antioxidant activity therefore works as a membranostabilizator, an adaptogen and a tserebroprotektor in an oxidatic stress of various genesis.

activity of the structures entering a limbiko-reticular complex, in particular on emotsiogenny zones of a hypothalamus and also influences all 4 main neuromediator systems — GAMK, sincaline - serotonin - and adrenergic, promoting their balance and integration, but has no peripheral adrenonegativny effect. At a neuromediator profile of effect of the medicament Adaptol there is a dofaminpolozhitelny component. Drug shows antagonistic activity concerning excitement of adrenergic and glutamatergichesky systems and strengthens functioning brake serotonin - and GAMK-ergichesky mechanisms of a brain. Has normosthenic properties.

Adaptol weakens nicotinic abstinency.

Pharmacokinetics. At oral administration the bioavailability is 77–80%; up to 40% of medicament contacts erythrocytes; the others — 60% do not contact blood proteins and are in blood plasma in a stand-at-ease in this connection medicament widely spreads in an organism and gets through membranes. The C _max in blood plasma is reached in 30 min., the high level of concentration remains during 3–4 h, then gradually decreases. Drug is completely removed from an organism with urine within a day, does not collect and is not subject to biochemical transformations in an organism.

Indication

Neurosises and neurosis-like states which are followed by irritability, emotional lability, feeling of alarm and fear; for improvement of shipping of neuroleptics or tranquilizers for the purpose of elimination of the somatovegetative and neurologic side effects caused by them; the cardialgias of various genesis (which are not connected with an ischemic heart disease); for simplification of a course of somatovegetative manifestations at a premenstrual syndrome and a menopause.

as a tserebroprotektor and an adaptogen in an emotional and oxidative stress of various genesis. As a part of complex therapy of nicotine addiction as the means reducing thirst for smoking.

Use

Adaptol is appointed inside irrespective of meal. the adult on 300–500 mg 2–3 times a day. the maximum dose on 1 reception — 3 g, daily — 10 g duration of a course of treatment — from several days to 2–3 months in case of need prescribing of medicament to children aged from 10 years is recommended to apply tablets adaptol 500 mg which it is possible to halve 250 mg for receiving a dose.

For treatment in nicotine addiction the medicament is taken on 500–1000 mg by 3 times a day daily during 5–6 weeks

Contraindication

Individual hypersensitivity to Mebicarum or components of drug. period of pregnancy and feeding by a breast.

Usually medicament is transferred by

well.

Disturbance from a cardiovascular system: decrease in the ABP.

Disturbance from a GIT: seldom — dispeptic disturbances. In that case it is necessary to lower a medicament dose.

Disturbance from a respiratory system: seldom — a bronchospasm.

Disturbance from skin and hypodermic cellulose: seldom — after reception in high doses allergic reactions (rash, an itching, a bronchospasm) are possible. In case of allergic reaction the administration of medicament is stopped.

General disturbances: seldom — a hypothermia, weakness. At decrease in the ABP and/or a hypothermia (body temperature can decrease by 1-1.5 °C) the administration of medicament should not be stopped. ABP and body temperature are normalized independently.

Special instructions

by

.

With care should be applied in abnormal liver functions and kidneys, at patients in arterial hypotension.

Use during pregnancy and feeding by a breast. Adaptol well gets into all fabrics and liquids of an organism. There are no sufficient data concerning safety of use of medicament during pregnancy and feeding by a breast therefore prescribing of medicament is not recommended to pregnant women and nursing.

Children. Experience of use for children is absent.

Ability to influence speed of response at control of vehicles or work with other mechanisms. It is necessary to be careful at control of vehicles as use of medicament can sometimes cause decrease in the ABP.

Interaction

Adaptol can be combined with neuroleptics, tranquilizers (benzodiazepine), hypnotic drugs, antidepressants and psychostimulants.

Overdose

Adaptol malotoksichen. at considerable overdose strengthening of side effects is possible (allergic reactions, dispeptic disturbances, temporary decrease hell and body temperatures).

Treatment: carry out the standard methods of desintoxication, including gastric lavage.

Storage conditions

At a temperature not above 25 °C. to store out of children's reach. prescription status — without prescription.