Acetylcysteinum - the means applied at cough and catarrhal diseases for treatment of the sharp and chronic diseases of a bronchopulmonary system demanding reduction of viscosity of a phlegm, improvement of its otkhozhdeniye and expectoration.

Structure

• active ingredient: acetylcysteine;
• 1 tablet contains Acetylcysteinum of 600 mg;
• other components: tartaric acid, citric acid, aspartame (E 951), saccharin of sodium, lactose monohydrate, cellulose microcrystalline, krospovidon, magnesium stearate, polyethyleneglycol, silicon dioxide colloidal waterless, peppermint oil.

Contraindication

Hypersensitivity to Acetylcysteinum or to other components of this medicine; a peptic ulcer of a stomach and duodenum in an aggravation stage, a pneumorrhagia, pulmonary bleeding; diseases of a liver, kidneys, adrenal glands.

Side reactions

from nervous system: headaches.

from organs of hearing and a labyrinth: sonitus.

from a respiratory system: dispnoe, a bronchospasm – mainly at patients with a hyperreactive bronchial system in case of bronchial asthma.

from a digestive tract: stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

from a cardiovascular system: tachycardia, arterial hypotension; it was reported about bleeding cases at use of Acetylcysteinum, sometimes because of reactions of hypersensitivity. In various researches the decrease in an accumulation of platelets in the presence of Acetylcysteinum was proved. The clinical importance of data is not established.

General violations: allergic reactions, including itch, urticaria, dieback, Quincke's disease, fever, anaphylactic reactions or even shock; also there are messages about heavy skin reactions, such as Stephens's syndrome – Johnson and a Lyell's disease which developed in treatment time Acetylcysteinum. In case of change of skin or a mucous membrane it is necessary to see immediately a doctor and to stop use of Acetylcysteinum.

Route of administration to Adults and children of 14 years to appoint

by

on 400–600 mg of Acetylcysteinum a day which distributes on 1–3 receptions.

is recommended to take the Drug after a meal. The tablet should be dissolved in a glass of water and to drink as soon as possible. The additional use of liquid enhances mucolytic effect of medicine.

Term of treatment of chronic diseases is defined by the doctor depending on character and the course of a disease. In sharp uncomplicated diseases to apply Acetylcysteinum of 5-7 days.

Use during pregnancy or feeding by a breast

Clinical data on influence of Acetylcysteinum on pregnant women are limited to

Feature of application

. There are no data on an occasion of penetration into breast milk. It is possible to appoint medicine during pregnancy and feeding a breast only when the expected advantage for mother exceeds potential risk for a fruit or the child.

Children

to Apply

to children aged from 14 years.

Ability to influence speed of response at control of motor transport or other mechanisms

Acetylcysteinum does not affect ability to drive the car and other mechanisms.

Overdose

Is not present data on overdose cases at oral administration of Acetylcysteinum.

Symptoms: nausea, vomiting, diarrhea. For children there is a risk of hypersecretion.

Therapy: symptomatic.

Interaction with other medicines and other types of interactions

medicine Combination with antibechic medicines can reduce a tussive reflex that will promote dangerous accumulation of a phlegm therefore this medicine should not be applied at the same time.

Drug pharmacological is incompatible

with antibiotics and proteolytic enzymes. Reduces absorption of penicillin, cephalosporins, tetracyclines, aminoglycosides. The interval between their reception has to make not less than 2 hours. It does not concern a tseffix and a lorakarbef.

by

notes synergism of Acetylcysteinum with bronchial spasmolytics. At contact with metals or rubber, sulfides with a characteristic smell are formed. There are data on strengthening of vasodilating and antitrombotichesky effect of nitroglycerine at simultaneous application with Acetylcysteinum.

Activated carbon reduces efficiency of Acetylcysteinum.

Concomitant use of nitroglycerine and Acetylcysteinum can enhance vazodilatatorny effect of nitroglycerine. In need of co-administration the careful observation of the patient for early detection of hypotension which can be serious is required and be shown by a headache.

Laboratory characteristics: use of Acetylcysteinum can change results of quantitative definition of salicylates in the colorimetric way and results of definition of ketone in urine.

Storage conditions

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.