Acetylcysteinum treatment of the sharp and chronic diseases of a bronchopulmonary system which are followed by the increased formation of a phlegm.

Overdose by paracetamol.

Structure

• active ingredient: Acetylcysteinum;
600 mg contain
• 1 sachet (3.0 g of powder) Acetylcysteinum;
• other components: sucrose, fragrance wild berry (a blackcurrant juice concentrate, ethyl acetate, terpinenol-4 natural, D-camphor, hepta-2.4-diyenal, maltodextrin, glitserol triacetate, a dextrin, acetic acid), offend

Contraindication

hypersensitivity to Acetylcysteinum or any of excipients Is known.

Peptic ulcer of a stomach and duodenum in stages of aggravation, a pneumorrhagia, pulmonary bleeding.

Children's age up to 12 years. It not a contraindication to application at overdose treatment by paracetamol.

Adults and children of 12 years of 1 sachet of 600 mg to dissolve

in 1/2 glasses of water and to accept 1 time a day.

Duration of a course of treatment is defined by the doctor individually depending on the nature of a disease (sharp or chronic).

Overdose by paracetamol

B the first 10 h after intake of toxic substance as soon as possible should apply Acetylcysteinum at the rate of 140 mg/kg, further – at the rate of 70 mg/kg each 4 hours within 1–3 days.

Acetylcysteinum needs to be accepted immediately, at once after solution preparation.

Feature of application

Use during pregnancy or feeding by a breast

it is necessary to Take the medicament during pregnancy or feeding by a breast only after careful assessment of a ratio advantage/risk.

to Apply

to children aged from 12 years.

Ability to influence speed of response at control of motor transport or other mechanisms

Is not present confirmation that Acetylcysteinum affects ability to drive the car and other mechanisms.

Overdose

Is not present data on cases of overdose of the dosage forms of Acetylcysteinum intended for application inside.

data on application to the volunteers accepting 11.6 g of Acetylcysteinum a day within three months without emergence of any serious side effects Are available.

Acetylcysteinum at reception in doses of 500 mg/kg/days does not cause overdose.

Symptoms.

Overdose can be shown by gastrointestinal symptoms, such as nausea, vomiting and diarrhea.

Treatment.

Specific antidote at poisoning with Acetylcysteinum, therapy symptomatic.

Researches of interaction were conducted by

only with participation of adults.

Use together with Acetylcysteinum of antibechics can increase stagnation of a phlegm because of oppression of a tussive reflex.

Activated carbon reduces efficiency of Acetylcysteinum.

At simultaneous application with such antibiotics as tetracyclines (except for doxycycline), ampicillin, Amphotericinum B, cephalosporins, aminoglycosides their interaction with thiol group of Acetylcysteinum is possible

that leads to decrease of the activity of both medicines. Therefore the interval between use of these medicines has to make not less than 2 hours. It does not concern a tseffix and a lorakarbef.

by

At a concomitant use of nitroglycerine and Acetylcysteinum found considerable hypotensions and expansion of a temporal artery. In need of simultaneous use of nitroglycerine and Acetylcysteinum for patients it is necessary to control hypotension which can have difficult character, and it is necessary to warn them about possibility of headaches.

Atsetiltsistein can be the donor of cysteine and increase the level of the glutathione promoting a detoxication of free radicals of oxygen and certain toxics in an organism.

Impact on laboratory researches

Acetylcysteinum can influence a colorimetric research of salicylates and definition of ketone bodies in urine.

Storage conditions

to Store

at a temperature not above 25 °C.

to Store

out of children's reach.